Date published: 2026-1-10

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DSCR 8 Inhibitors

DSCR 8 inhibitors are a class of chemical compounds designed to inhibit the activity of DSCR 8, a gene or protein associated with the Down syndrome critical region (DSCR), which is located on chromosome 21. DSCR 8 is believed to play a role in various cellular processes, potentially influencing gene expression regulation, RNA processing, or intracellular signaling pathways. While the exact functions of DSCR 8 are still under investigation, it is hypothesized to contribute to regulatory networks that control developmental or cellular growth-related mechanisms. Inhibitors targeting DSCR 8 aim to modulate its activity, providing a means to study its functional role in cellular dynamics and molecular signaling pathways. By inhibiting DSCR 8, researchers can gain insight into how this gene or protein impacts the broader regulatory landscape of the cell.

The structural design of DSCR 8 inhibitors is generally focused on interacting with the key domains of the protein that are critical for its function, such as binding regions that may interact with RNA, DNA, or other regulatory proteins. These inhibitors may work through competitive inhibition by blocking the active site or binding domains, or they may act through allosteric mechanisms that induce conformational changes, reducing the activity of DSCR 8. The study of DSCR 8 inhibitors provides researchers with valuable tools for dissecting the molecular pathways in which DSCR 8 is involved, offering insights into the regulatory networks that govern cell behavior. Additionally, understanding the effects of DSCR 8 inhibition may shed light on the broader functional roles of genes within the Down syndrome critical region, enhancing the knowledge of chromosome 21's contribution to cellular regulation.

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Items 1 to 10 of 11 total

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Product NameCAS #Catalog #QUANTITYPriceCitationsRATING

5-Azacytidine

320-67-2sc-221003
500 mg
$280.00
4
(1)

This cytidine analog could hypothetically lead to the demethylation of the DSCR 8 gene's promoter, thereby silencing its transcriptional activity.

Trichostatin A

58880-19-6sc-3511
sc-3511A
sc-3511B
sc-3511C
sc-3511D
1 mg
5 mg
10 mg
25 mg
50 mg
$152.00
$479.00
$632.00
$1223.00
$2132.00
33
(3)

This agent could hypothetically prevent the deacetylation of histones associated with the DSCR 8 gene, leading to a condensed chromatin structure and decreased gene expression.

Sodium Butyrate

156-54-7sc-202341
sc-202341B
sc-202341A
sc-202341C
250 mg
5 g
25 g
500 g
$31.00
$47.00
$84.00
$222.00
19
(3)

This short-chain fatty acid might reduce the expression of DSCR 8 by hyperacetylating histones, which can suppress gene transcription.

Retinoic Acid, all trans

302-79-4sc-200898
sc-200898A
sc-200898B
sc-200898C
500 mg
5 g
10 g
100 g
$66.00
$325.00
$587.00
$1018.00
28
(1)

As a ligand for retinoic acid receptors, it could decrease the transcriptional activity of DSCR 8 by altering the binding of transcription machinery to its promoter region.

Rapamycin

53123-88-9sc-3504
sc-3504A
sc-3504B
1 mg
5 mg
25 mg
$63.00
$158.00
$326.00
233
(4)

By inhibiting the mTOR pathway, this compound could result in the downregulation of protein synthesis machinery, potentially leading to reduced synthesis of DSCR 8.

LY 294002

154447-36-6sc-201426
sc-201426A
5 mg
25 mg
$123.00
$400.00
148
(1)

This compound could decrease the expression of DSCR 8 by inhibiting PI3K, leading to reduced activity of downstream protein synthesis pathways.

SP600125

129-56-6sc-200635
sc-200635A
10 mg
50 mg
$40.00
$150.00
257
(3)

This specific inhibitor could decrease DSCR 8 expression by blocking JNK-mediated signaling pathways that promote transcriptional activation of certain genes.

SB 203580

152121-47-6sc-3533
sc-3533A
1 mg
5 mg
$90.00
$349.00
284
(5)

This inhibitor may lower the expression of DSCR 8 by preventing p38 MAPK-induced activation of transcription factors that enhance gene expression.

U-0126

109511-58-2sc-222395
sc-222395A
1 mg
5 mg
$64.00
$246.00
136
(2)

This MEK inhibitor might reduce DSCR 8 expression by inhibiting the ERK/MAPK signaling cascade, which is crucial for the transcription of many genes.

Bortezomib

179324-69-7sc-217785
sc-217785A
2.5 mg
25 mg
$135.00
$1085.00
115
(2)

By inhibiting the proteasome, this drug might lead to the accumulation of repressive factors that reduce DSCR 8 gene expression.