DSCR 8 inhibitors are a class of chemical compounds designed to inhibit the activity of DSCR 8, a gene or protein associated with the Down syndrome critical region (DSCR), which is located on chromosome 21. DSCR 8 is believed to play a role in various cellular processes, potentially influencing gene expression regulation, RNA processing, or intracellular signaling pathways. While the exact functions of DSCR 8 are still under investigation, it is hypothesized to contribute to regulatory networks that control developmental or cellular growth-related mechanisms. Inhibitors targeting DSCR 8 aim to modulate its activity, providing a means to study its functional role in cellular dynamics and molecular signaling pathways. By inhibiting DSCR 8, researchers can gain insight into how this gene or protein impacts the broader regulatory landscape of the cell.
The structural design of DSCR 8 inhibitors is generally focused on interacting with the key domains of the protein that are critical for its function, such as binding regions that may interact with RNA, DNA, or other regulatory proteins. These inhibitors may work through competitive inhibition by blocking the active site or binding domains, or they may act through allosteric mechanisms that induce conformational changes, reducing the activity of DSCR 8. The study of DSCR 8 inhibitors provides researchers with valuable tools for dissecting the molecular pathways in which DSCR 8 is involved, offering insights into the regulatory networks that govern cell behavior. Additionally, understanding the effects of DSCR 8 inhibition may shed light on the broader functional roles of genes within the Down syndrome critical region, enhancing the knowledge of chromosome 21's contribution to cellular regulation.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
5-Azacytidine | 320-67-2 | sc-221003 | 500 mg | $280.00 | 4 | |
This cytidine analog could hypothetically lead to the demethylation of the DSCR 8 gene's promoter, thereby silencing its transcriptional activity. | ||||||
Trichostatin A | 58880-19-6 | sc-3511 sc-3511A sc-3511B sc-3511C sc-3511D | 1 mg 5 mg 10 mg 25 mg 50 mg | $152.00 $479.00 $632.00 $1223.00 $2132.00 | 33 | |
This agent could hypothetically prevent the deacetylation of histones associated with the DSCR 8 gene, leading to a condensed chromatin structure and decreased gene expression. | ||||||
Sodium Butyrate | 156-54-7 | sc-202341 sc-202341B sc-202341A sc-202341C | 250 mg 5 g 25 g 500 g | $31.00 $47.00 $84.00 $222.00 | 19 | |
This short-chain fatty acid might reduce the expression of DSCR 8 by hyperacetylating histones, which can suppress gene transcription. | ||||||
Retinoic Acid, all trans | 302-79-4 | sc-200898 sc-200898A sc-200898B sc-200898C | 500 mg 5 g 10 g 100 g | $66.00 $325.00 $587.00 $1018.00 | 28 | |
As a ligand for retinoic acid receptors, it could decrease the transcriptional activity of DSCR 8 by altering the binding of transcription machinery to its promoter region. | ||||||
Rapamycin | 53123-88-9 | sc-3504 sc-3504A sc-3504B | 1 mg 5 mg 25 mg | $63.00 $158.00 $326.00 | 233 | |
By inhibiting the mTOR pathway, this compound could result in the downregulation of protein synthesis machinery, potentially leading to reduced synthesis of DSCR 8. | ||||||
LY 294002 | 154447-36-6 | sc-201426 sc-201426A | 5 mg 25 mg | $123.00 $400.00 | 148 | |
This compound could decrease the expression of DSCR 8 by inhibiting PI3K, leading to reduced activity of downstream protein synthesis pathways. | ||||||
SP600125 | 129-56-6 | sc-200635 sc-200635A | 10 mg 50 mg | $40.00 $150.00 | 257 | |
This specific inhibitor could decrease DSCR 8 expression by blocking JNK-mediated signaling pathways that promote transcriptional activation of certain genes. | ||||||
SB 203580 | 152121-47-6 | sc-3533 sc-3533A | 1 mg 5 mg | $90.00 $349.00 | 284 | |
This inhibitor may lower the expression of DSCR 8 by preventing p38 MAPK-induced activation of transcription factors that enhance gene expression. | ||||||
U-0126 | 109511-58-2 | sc-222395 sc-222395A | 1 mg 5 mg | $64.00 $246.00 | 136 | |
This MEK inhibitor might reduce DSCR 8 expression by inhibiting the ERK/MAPK signaling cascade, which is crucial for the transcription of many genes. | ||||||
Bortezomib | 179324-69-7 | sc-217785 sc-217785A | 2.5 mg 25 mg | $135.00 $1085.00 | 115 | |
By inhibiting the proteasome, this drug might lead to the accumulation of repressive factors that reduce DSCR 8 gene expression. | ||||||