DSC1A Activators
DSC1A, also known as Desmocollin-1A, is a crucial component of the desmosomes, which are specialized structures that facilitate strong cell-cell adhesion, particularly in epithelial tissues. Desmocollins, along with desmogleins, establish the adhesive intercellular contacts that are pivotal for maintaining the integrity and mechanical stability of epithelial sheets. The expression of DSC1A is of particular interest in the context of cellular differentiation and tissue integrity, as it is intimately involved in the structural cohesion necessary for tissue form and function. Chemical activators of DSC1A expression, therefore, are substances that can upregulate the gene at a transcriptional level, leading to an increase in the protein product and potentially fortifying cellular adhesion.
A variety of chemical compounds have been identified that could potentially serve as activators of DSC1A expression. For instance, retinoids like retinoic acid and tretinoin are known to play a role in skin health and cell differentiation by binding to nuclear receptors, which may result in the upregulation of genes, including DSC1A, that are essential for epidermal function. Compounds such as forskolin can raise intracellular cAMP levels, which may initiate a signaling cascade culminating in the enhanced transcription of DSC1A. Histone deacetylase inhibitors, such as Trichostatin A and Sodium Butyrate, could promote a transcription-friendly chromatin state around the DSC1A gene, potentially leading to its increased expression. Moreover, epigenetic modulators like 5-Azacytidine may induce gene expression by reversing DNA methylation in the promoter regions of genes, which could include DSC1A. It's also plausible that compounds influencing cellular signaling pathways, such as lithium chloride, could indirectly result in the upregulation of DSC1A by modulating the activity of enzymes and other factors involved in gene expression. Each of these compounds interacts with the cell's biochemical machinery in a way that could lead to the elevation of DSC1A levels, contributing to the functional competence of epithelial barriers
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Retinoic Acid, all trans | 302-79-4 | sc-200898 sc-200898A sc-200898B sc-200898C | 500 mg 5 g 10 g 100 g | $65.00 $319.00 $575.00 $998.00 | 28 | |
Retinoic acid is known to initiate transcriptional events in epithelial cell differentiation, which could theoretically upregulate DSC1A expression as part of the specialization process of skin cells. | ||||||
Cholecalciferol | 67-97-0 | sc-205630 sc-205630A sc-205630B | 1 g 5 g 10 g | $70.00 $160.00 $290.00 | 2 | |
Cholecalciferol, through its metabolite calcitriol, may stimulate the transcription of genes involved in skin homeostasis, potentially leading to an increase in DSC1A gene expression. | ||||||
5-Azacytidine | 320-67-2 | sc-221003 | 500 mg | $280.00 | 4 | |
As a cytidine analog, 5-Azacytidine could potentially induce the expression of DSC1A by inhibiting the methylation of cytosine bases within the gene's promoter region, thus facilitating transcription. | ||||||
Trichostatin A | 58880-19-6 | sc-3511 sc-3511A sc-3511B sc-3511C sc-3511D | 1 mg 5 mg 10 mg 25 mg 50 mg | $149.00 $470.00 $620.00 $1199.00 $2090.00 | 33 | |
Trichostatin A may upregulate DSC1A expression by preventing the deacetylation of histones, thereby maintaining a transcriptionally active chromatin structure around the DSC1A gene. | ||||||
(−)-Epigallocatechin Gallate | 989-51-5 | sc-200802 sc-200802A sc-200802B sc-200802C sc-200802D sc-200802E | 10 mg 50 mg 100 mg 500 mg 1 g 10 g | $42.00 $72.00 $124.00 $238.00 $520.00 $1234.00 | 11 | |
Epigallocatechin Gallate may upregulate the expression of DSC1A by altering signal transduction pathways that govern cell proliferation and survival, which are essential for maintaining skin integrity. | ||||||
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $76.00 $150.00 $725.00 $1385.00 $2050.00 | 73 | |
By raising intracellular cAMP levels, forskolin could stimulate a signaling cascade that leads to the upregulation of DSC1A, tying in with the maintenance of intercellular junctions. | ||||||
PMA | 16561-29-8 | sc-3576 sc-3576A sc-3576B sc-3576C sc-3576D | 1 mg 5 mg 10 mg 25 mg 100 mg | $40.00 $129.00 $210.00 $490.00 $929.00 | 119 | |
PMA could potentially stimulate DSC1A expression via the activation of the PKC pathway, which is implicated in the control of cellular adhesion processes. | ||||||
Lithium | 7439-93-2 | sc-252954 | 50 g | $214.00 | ||
Lithium Chloride might upregulate DSC1A expression by inhibiting GSK-3, which is known to participate in signaling pathways related to cell growth and differentiation. | ||||||
β-Estradiol | 50-28-2 | sc-204431 sc-204431A | 500 mg 5 g | $62.00 $178.00 | 8 | |
β-Estradiol may stimulate the expression of DSC1A in tissues that are estrogen-responsive, leading to an increase in cellular adhesion mechanisms. | ||||||
Dimethyl Sulfoxide (DMSO) | 67-68-5 | sc-202581 sc-202581A sc-202581B | 100 ml 500 ml 4 L | $30.00 $115.00 $900.00 | 136 | |
DMSO could upregulate DSC1A expression indirectly by enhancing the penetration of other small molecules that act as transcriptional activators of the DSC1A gene. | ||||||