Dppa1 Activators
Dppa1, encoding the developmental pluripotency-associated protein 1, exhibits diverse functions including phosphatidylserine binding and virus receptor activity. Involved in phagocytosis, engulfment, and positive regulation of mast cell activation, it is active on the cell surface and expressed in various tissues. Activation of Dppa1 involves a dynamic interplay of direct and indirect activators. Phosphatidylserine directly activates Dppa1 by binding to its predicted binding site, enhancing its role in phagocytosis and cellular responses. Poly I:C indirectly activates Dppa1 by simulating antiviral responses, promoting its involvement as a virus receptor. Mastoparan indirectly activates Dppa1 by triggering mast cell activation, enhancing its potential role in immune modulation. Lipopolysaccharide indirectly influences mast cell activation, contributing to Dppa1's participation in immune responses. Phorbol 12-myristate 13-acetate indirectly activates Dppa1 by promoting phagocytosis, linking its function to cellular responses to external stimuli. Imiquimod indirectly influences virus receptor activity, enhancing Dppa1's ability to recognize viral particles.
Anandamide indirectly modulates phosphatidylserine binding, supporting Dppa1's involvement in cellular processes. Zymosan indirectly activates Dppa1 by inducing mast cell degranulation, amplifying its role in immune responses. N-Acetylcysteine indirectly influences virus receptor activity, contributing to Dppa1's engagement with viral entities. Mannose indirectly activates Dppa1 by promoting mast cell activation, linking it to immune modulation. Crocidolite asbestos indirectly influences phagocytosis, connecting Dppa1 to responses against environmental stimuli. Heparin indirectly modulates phosphatidylserine binding, supporting Dppa1's involvement in cellular processes. This comprehensive understanding of Dppa1's activation provides insights into its multifaceted functions and regulatory mechanisms, highlighting its importance in cellular responses and potential implications in various physiological contexts.
SEE ALSO...
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Phosphatidyl-L-serine | 51446-62-9 | sc-507548 | 10 g | $46.00 | ||
Phosphatidylserine directly activates Dppa1 by binding to its predicted phosphatidylserine binding site. This direct interaction triggers a conformational change in Dppa1, enhancing its affinity for phosphatidylserine and promoting its involvement in cellular processes like phagocytosis and engulfment. | ||||||
Polyinosinic acid - polycytidylic acid sodium salt, double-stranded | 42424-50-0 | sc-204854 sc-204854A | 10 mg 100 mg | $139.00 $663.00 | 2 | |
Poly I:C indirectly activates Dppa1 by influencing virus receptor activity. Recognized as a viral mimic, poly I:C stimulates cellular antiviral responses, indirectly promoting Dppa1's engagement as a virus receptor. This indirect activation enhances Dppa1's role in recognizing viral particles and modulating cellular responses. | ||||||
Mastoparan | 72093-21-1 | sc-200831 | 1 mg | $99.00 | ||
Mastoparan indirectly activates Dppa1 by triggering positive regulation of mast cell activation. This peptide toxin enhances mast cell degranulation, leading to the release of factors that indirectly stimulate Dppa1. This activation promotes Dppa1's involvement in mast cell activation and its potential role in modulating immune responses. | ||||||
PMA | 16561-29-8 | sc-3576 sc-3576A sc-3576B sc-3576C sc-3576D | 1 mg 5 mg 10 mg 25 mg 100 mg | $41.00 $132.00 $214.00 $500.00 $948.00 | 119 | |
PMA indirectly activates Dppa1 by promoting phagocytosis and engulfment. PMA stimulates protein kinase C (PKC) activation, leading to enhanced phagocytic activity. This indirect activation amplifies Dppa1's role in phagocytosis and engulfment, modulating cellular responses to external stimuli. | ||||||
Imiquimod | 99011-02-6 | sc-200385 sc-200385A | 100 mg 500 mg | $67.00 $284.00 | 6 | |
Imiquimod indirectly activates Dppa1 by influencing virus receptor activity. As a Toll-like receptor 7 agonist, imiquimod stimulates antiviral responses, indirectly promoting Dppa1's engagement as a virus receptor. This indirect activation enhances Dppa1's ability to recognize viral particles and modulate cellular responses. | ||||||
Zymosan A from Saccharomyces cerevisiae | 58856-93-2 | sc-258367 sc-258367A | 250 mg 1 g | $90.00 $222.00 | 2 | |
Zymosan indirectly activates Dppa1 by promoting positive regulation of mast cell activation. Zymosan, a fungal cell wall component, induces mast cell degranulation, leading to the release of factors that indirectly stimulate Dppa1. This indirect activation amplifies Dppa1's role in mast cell activation and immune modulation. | ||||||
N-Acetyl-L-cysteine | 616-91-1 | sc-202232 sc-202232A sc-202232C sc-202232B | 5 g 25 g 1 kg 100 g | $34.00 $74.00 $270.00 $114.00 | 34 | |
N-Acetylcysteine indirectly activates Dppa1 by modulating virus receptor activity. NAC exhibits antioxidant properties, indirectly influencing cellular responses to viral particles and promoting Dppa1's engagement as a virus receptor. This indirect activation enhances Dppa1's ability to recognize viral entities. | ||||||
D-Mannose | 3458-28-4 | sc-211180 sc-211180A | 100 g 250 g | $103.00 $161.00 | 1 | |
Mannose indirectly activates Dppa1 by promoting positive regulation of mast cell activation. Mannose, a sugar, enhances mast cell degranulation, leading to the release of factors that indirectly stimulate Dppa1. This indirect activation amplifies Dppa1's role in mast cell activation and immune modulation. | ||||||
Heparin | 9005-49-6 | sc-507344 | 25 mg | $119.00 | 1 | |
Heparin sodium salt indirectly activates Dppa1 by influencing phosphatidylserine binding activity. As a glycosaminoglycan, heparin modulates cellular membrane composition, indirectly supporting Dppa1's binding to phosphatidylserine. This indirect activation enhances Dppa1's involvement in cellular processes like phagocytosis. | ||||||