DOCK 7 Inhibitors

DOCK7-related inhibitors comprise a diverse group of chemicals primarily targeting proteins and pathways associated with or influencing DOCK7 functions. DOCK7 is a guanine nucleotide exchange factor that plays a crucial role in actin cytoskeleton dynamics, neuronal growth, and cell morphology. Given the absence of direct inhibitors, the chemicals listed focus on targeting signaling pathways and proteins that interact or are co-regulated with DOCK7. The primary mode of action of these inhibitors involves targeting GTPases like Rac1 and Cdc42 or their regulators. For instance, NSC23766 and CID2950007 inhibit Rac1, a small GTPase that often collaborates with DOCK7 in regulating actin cytoskeleton and cell migration. By inhibiting Rac1, these compounds can indirectly modulate DOCK7-mediated cellular processes. Similarly, ML141, CASIN, and ZCL278 are inhibitors of Cdc42, another GTPase that, in certain contexts, works in conjunction with DOCK7. Inhibition of Cdc42 can affect cellular activities where both DOCK7 and Cdc42 are involved, particularly in cell shape and movement.

Additionally, compounds like ITX3 and Tozasertib target other proteins in signaling pathways that may intersect with DOCK7 functions. ITX3 inhibits Trio, a guanine nucleotide exchange factor, potentially impacting pathways that involve DOCK7 in neuronal growth and cell signaling. Tozasertib, an Aurora kinase inhibitor, can indirectly affect cell division and migration processes where DOCK7 plays a role. The inclusion of Rho kinase inhibitors like GSK269962A highlights the interconnected nature of intracellular signaling pathways. While not directly targeting DOCK7, these inhibitors can influence cellular processes where DOCK7 is a key player, particularly in the context of cytoskeletal dynamics and cell migration.