DOCK 7 Antibody (C-7): sc-398888
- DOCK 7 Antibody (C-7) is a mouse monoclonal IgG2b κ DOCK 7 antibody provided at 200 µg/ml
- raised against amino acids 151-260 mapping near the N-terminus of DOCK 7 of human origin
- DOCK 7 Antibody (C-7) is recommended for detection of DOCK 7 of mouse, rat and human origin by WB, IP, IF and ELISA
- Anti-DOCK 7 Antibody (C-7) is available conjugated to agarose for IP; HRP for WB, IHC(P) and ELISA; and to either phycoerythrin or FITC for IF, IHC(P) and FCM
- also available conjugated to Alexa Fluor® 488, Alexa Fluor® 546, Alexa Fluor® 594 or Alexa Fluor® 647 for WB (RGB), IF, IHC(P) and FCM, and for use with RGB fluorescent imaging systems, such as iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- also available conjugated to Alexa Fluor® 680 or Alexa Fluor® 790 for WB (NIR), IF and FCM; for use with Near-Infrared (NIR) detection systems, such as LI-COR®Odyssey®, iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- m-IgG Fc BP-HRP, m-IgG2b BP-HRP and m-IgGκ BP-HRP are the preferred secondary detection reagents for DOCK 7 Antibody (C-7) for WB applications. These reagents are now offered in bundles with DOCK 7 Antibody (C-7) (see ordering information below).
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DOCK 7 Antibody (C-7) is a mouse monoclonal IgG2b kappa light chain antibody that detects DOCK 7 protein of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). DOCK 7 (C-7) antibody is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. DOCK 7 protein, also known as dedicator of cytokinesis 7 or ZIR2, is a crucial guanine nucleotide exchange factor (GEF) that plays a significant role in the activation of Rac1 and Rac3, which are essential for cytoskeletal dynamics and cellular signaling. DOCK 7 consists of 2,140 amino acids and is primarily localized to developing axons, where DOCK 7 facilitates the regulation of neuronal morphology and migration. The presence of one DHR-1 domain and one DHR-2 domain in DOCK 7′s structure is vital for GEF activity, allowing for the exchange of GDP for GTP, which is a critical step in the activation of downstream signaling pathways. DOCK 7 is expressed in various tissues, and DOCK 7′s gene is located on human chromosome 1, a region associated with numerous disease-related genes, including those implicated in familial adenomatous polyposis and Parkinson′s disease. Notably, aberrations in chromosome 1 have been linked to several cancers, highlighting DOCK 7′s importance in both normal cellular function and disease states.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
DOCK 7 Antibody (C-7) References:
- Identification of an evolutionarily conserved superfamily of DOCK180-related proteins with guanine nucleotide exchange activity. | Côté, JF. and Vuori, K. 2002. J Cell Sci. 115: 4901-13. PMID: 12432077
- Phosphorylation and binding partner analysis of the TSC1-TSC2 complex. | Nellist, M., et al. 2005. Biochem Biophys Res Commun. 333: 818-26. PMID: 15963462
- Nervous Rac: DOCK7 regulation of axon formation. | Pinheiro, EM. and Gertler, FB. 2006. Neuron. 51: 674-6. PMID: 16982410
- The Rac activator DOCK7 regulates neuronal polarity through local phosphorylation of stathmin/Op18. | Watabe-Uchida, M., et al. 2006. Neuron. 51: 727-39. PMID: 16982419
- The tuberous sclerosis gene products hamartin and tuberin are multifunctional proteins with a wide spectrum of interacting partners. | Rosner, M., et al. 2008. Mutat Res. 658: 234-46. PMID: 18291711
- ErbB2 directly activates the exchange factor Dock7 to promote Schwann cell migration. | Yamauchi, J., et al. 2008. J Cell Biol. 181: 351-65. PMID: 18426980
- Mice with mutations of Dock7 have generalized hypopigmentation and white-spotting but show normal neurological function. | Blasius, AL., et al. 2009. Proc Natl Acad Sci U S A. 106: 2706-11. PMID: 19202056
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
DOCK 7 Antibody (C-7) | sc-398888 | 200 µg/ml | $322.00 | |||
DOCK 7 Antibody (C-7): m-IgG Fc BP-HRP Bundle | sc-530957 | 200 µg Ab; 10 µg BP | $361.00 | |||
DOCK 7 Antibody (C-7): m-IgGκ BP-HRP Bundle | sc-524523 | 200 µg Ab, 40 µg BP | $361.00 | |||
DOCK 7 Antibody (C-7): m-IgG2b BP-HRP Bundle | sc-550241 | 200 µg Ab; 10 µg BP | $361.00 | |||
DOCK 7 Antibody (C-7) AC | sc-398888 AC | 500 µg/ml, 25% agarose | $424.00 | |||
DOCK 7 Antibody (C-7) HRP | sc-398888 HRP | 200 µg/ml | $322.00 | |||
DOCK 7 Antibody (C-7) FITC | sc-398888 FITC | 200 µg/ml | $336.00 | |||
DOCK 7 Antibody (C-7) PE | sc-398888 PE | 200 µg/ml | $349.00 | |||
DOCK 7 Antibody (C-7) Alexa Fluor® 488 | sc-398888 AF488 | 200 µg/ml | $364.00 | |||
DOCK 7 Antibody (C-7) Alexa Fluor® 546 | sc-398888 AF546 | 200 µg/ml | $364.00 | |||
DOCK 7 Antibody (C-7) Alexa Fluor® 594 | sc-398888 AF594 | 200 µg/ml | $364.00 | |||
DOCK 7 Antibody (C-7) Alexa Fluor® 647 | sc-398888 AF647 | 200 µg/ml | $364.00 | |||
DOCK 7 Antibody (C-7) Alexa Fluor® 680 | sc-398888 AF680 | 200 µg/ml | $364.00 | |||
DOCK 7 Antibody (C-7) Alexa Fluor® 790 | sc-398888 AF790 | 200 µg/ml | $364.00 |