DOCK 11 inhibitors belong to a specific category of chemical compounds known for their ability to modulate the activity of the protein DOCK11. DOCK11, short for Dedicator of Cytokinesis 11, is a cytoplasmic protein that plays a pivotal role in regulating various cellular processes, particularly those associated with cellular signaling and cytoskeletal dynamics. Inhibitors targeting DOCK11 are designed to interact with the protein and interfere with its normal functions, thus potentially offering insights into its physiological roles and the development of new strategies for manipulating cellular processes.
These inhibitors are typically small organic molecules, characterized by their specific binding affinity for DOCK11. The mechanism of action of DOCK11 inhibitors involves their ability to bind to the active site or allosteric sites of the protein, hindering its normal interaction with other cellular components. By doing so, DOCK11 inhibitors can disrupt downstream signaling pathways and cellular processes that rely on the proper functioning of DOCK11. This chemical class plays a crucial role in advancing our understanding of cell biology and can serve as valuable tools in research to dissect the intricate mechanisms underlying cellular events mediated by DOCK11. Researchers employ DOCK11 inhibitors to gain insights into the fundamental processes governed by this protein, with potential applications spanning cell migration, cytoskeletal rearrangements, and intracellular signaling pathways
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Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
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Staurosporine | 62996-74-1 | sc-3510 sc-3510A sc-3510B | 100 µg 1 mg 5 mg | $82.00 $150.00 $388.00 | 113 | |
A potent kinase inhibitor that can prevent phosphorylation steps in various signaling pathways where DOCK11 is involved. | ||||||
LY 294002 | 154447-36-6 | sc-201426 sc-201426A | 5 mg 25 mg | $121.00 $392.00 | 148 | |
A PI3K inhibitor that can affect downstream signaling of DOCK11 by altering the PI3K/AKT pathway. | ||||||
SP600125 | 129-56-6 | sc-200635 sc-200635A | 10 mg 50 mg | $65.00 $267.00 | 257 | |
An inhibitor of JNK, which can modulate the activity of transcription factors that DOCK11 may influence. | ||||||
PP 2 | 172889-27-9 | sc-202769 sc-202769A | 1 mg 5 mg | $92.00 $223.00 | 30 | |
A Src family kinase inhibitor that could disrupt signaling pathways involving DOCK11. | ||||||
PD 98059 | 167869-21-8 | sc-3532 sc-3532A | 1 mg 5 mg | $39.00 $90.00 | 212 | |
A selective inhibitor of MEK that can alter signaling pathways where DOCK11 may play a role. | ||||||
SB 203580 | 152121-47-6 | sc-3533 sc-3533A | 1 mg 5 mg | $88.00 $342.00 | 284 | |
A p38 MAP kinase inhibitor that might affect stress response pathways involving DOCK11. | ||||||
Wortmannin | 19545-26-7 | sc-3505 sc-3505A sc-3505B | 1 mg 5 mg 20 mg | $66.00 $219.00 $417.00 | 97 | |
A PI3K inhibitor similar to LY294002, it can disturb the PI3K/AKT pathway which may be related to DOCK11 function. | ||||||
Rapamycin | 53123-88-9 | sc-3504 sc-3504A sc-3504B | 1 mg 5 mg 25 mg | $62.00 $155.00 $320.00 | 233 | |
An mTOR inhibitor that can disrupt downstream signaling potentially affecting DOCK11-mediated processes. | ||||||
Triciribine | 35943-35-2 | sc-200661 sc-200661A | 1 mg 5 mg | $102.00 $138.00 | 14 | |
An AKT inhibitor that could interfere with signaling pathways that DOCK11 may be involved in. | ||||||
Dasatinib | 302962-49-8 | sc-358114 sc-358114A | 25 mg 1 g | $47.00 $145.00 | 51 | |
A broad-spectrum tyrosine kinase inhibitor that might alter multiple pathways, including those involving DOCK11. |