DnaJB14 Activators
DnaJB14 activators are compounds that enhance the activity of DnaJB14 by affecting the cellular processes it is involved in or by providing more substrates for DnaJB14 to metabolize. The compounds identified here, including Cyclosporine A, FK506, Resveratrol, NAD+, Quercetin, Geldanamycin, EGCG, Curcumin, Sodium Arsenite, Celastrol, Deferoxamine, and Radicicol, interact with DnaJB14 directly or indirectly to enhance its functional activity. These compounds enhance the functional activity of DnaJB14 by indirectly affecting the pathways or processes that DnaJB14 is involved in. For instance, Cyclosporine A and FK506 are calcineurin inhibitors that affect DnaJB14 indirectly by inhibiting the dephosphorylation of NFAT, leading to the activation of DnaJB14. Similarly, Resveratrol and NAD+ enhance DnaJB14 activity by activating SIRT1, which isknown to activate DnaJB14 by deacetylation. The compounds Quercetin, EGCG, Curcumin, Sodium Arsenite, Celastrol, and Deferoxamine enhance DnaJB14 activity by activating HSF1, which then stimulates DnaJB14 expression. Geldanamycin and Radicicol, on the other hand, inhibit HSP90, which triggers a compensatory increase in other HSPs, including DnaJB14. These compounds, therefore, enhance the functional activity of DnaJB14 either by providing more substrates for it to work on or by indirectly affecting the cellular processes it is involved in.
Understanding the mechanisms by which these compounds enhance DnaJB14 activity can elucidate the specific roles and functions of DnaJB14 in various cellular processes. For example, the activation of DnaJB14 by SIRT1 deacetylation underscores the importance of post-translational modifications in regulating DnaJB14 activity. Furthermore, the activation of DnaJB14 by HSF1 points to the role of DnaJB14 in the heat shock response, a critical cellular process that protects cells from stress-induced damage.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Cyclosporin A | 59865-13-3 | sc-3503 sc-3503-CW sc-3503A sc-3503B sc-3503C sc-3503D | 100 mg 100 mg 500 mg 10 g 25 g 100 g | $62.00 $90.00 $299.00 $475.00 $1015.00 $2099.00 | 69 | |
Cyclosporine A is a calcineurin inhibitor that indirectly affects DnaJB14 by inhibiting the dephosphorylation of NFAT, a transcription factor that activates DnaJB14 expression. When calcineurin activity is limited, NFAT remains in the cytoplasm, leading to enhanced DnaJB14 function. | ||||||
FK-506 | 104987-11-3 | sc-24649 sc-24649A | 5 mg 10 mg | $76.00 $148.00 | 9 | |
Similar to Cyclosporine A, FK506 is a calcineurin inhibitor that leads to the cytoplasmic retention of NFAT. This action indirectly enhances the functional activity of DnaJB14 by promoting the activation of its expression. | ||||||
Resveratrol | 501-36-0 | sc-200808 sc-200808A sc-200808B | 100 mg 500 mg 5 g | $60.00 $185.00 $365.00 | 64 | |
Resveratrol, a polyphenolic compound, activates SIRT1, an NAD-dependent deacetylase. SIRT1 is known to enhance the activity of Heat Shock Proteins such as DnaJB14 by deacetylating them, leading to their activation. | ||||||
NAD+, Free Acid | 53-84-9 | sc-208084B sc-208084 sc-208084A sc-208084C sc-208084D sc-208084E sc-208084F | 1 g 5 g 10 g 25 g 100 g 1 kg 5 kg | $56.00 $186.00 $296.00 $655.00 $2550.00 $3500.00 $10500.00 | 4 | |
NAD+ indirectly enhances DnaJB14 activity by acting as a cofactor for SIRT1. It is required for SIRT1's deacetylase activity, which in turn activates DnaJB14. | ||||||
Quercetin | 117-39-5 | sc-206089 sc-206089A sc-206089E sc-206089C sc-206089D sc-206089B | 100 mg 500 mg 100 g 250 g 1 kg 25 g | $11.00 $17.00 $108.00 $245.00 $918.00 $49.00 | 33 | |
Quercetin is a flavonoid that increases the expression of Heat Shock Proteins (HSPs), including DnaJB14. It does so by stabilizing HSF1, the master regulator of the heat shock response, thereby promoting DnaJB14 activation. | ||||||
Geldanamycin | 30562-34-6 | sc-200617B sc-200617C sc-200617 sc-200617A | 100 µg 500 µg 1 mg 5 mg | $38.00 $58.00 $102.00 $202.00 | 8 | |
Geldanamycin is a HSP90 inhibitor. By inhibiting HSP90, Geldanamycin indirectly activates DnaJB14 by triggering a compensatory increase in other HSPs, including members of the DNAJ/HSP40 family to which DnaJB14 belongs. | ||||||
(−)-Epigallocatechin Gallate | 989-51-5 | sc-200802 sc-200802A sc-200802B sc-200802C sc-200802D sc-200802E | 10 mg 50 mg 100 mg 500 mg 1 g 10 g | $42.00 $72.00 $124.00 $238.00 $520.00 $1234.00 | 11 | |
Epigallocatechin gallate (EGCG) is a polyphenol found in green tea known to stimulate the expression of HSPs. EGCG enhances DnaJB14 activity by increasing HSF1, the master regulator of heat shock response. | ||||||
Curcumin | 458-37-7 | sc-200509 sc-200509A sc-200509B sc-200509C sc-200509D sc-200509F sc-200509E | 1 g 5 g 25 g 100 g 250 g 1 kg 2.5 kg | $36.00 $68.00 $107.00 $214.00 $234.00 $862.00 $1968.00 | 47 | |
Curcumin, a polyphenolic compound found in turmeric, is known to induce the expression of HSPs. It does so by activating HSF1, thereby leading to the enhanced function of DnaJB14. | ||||||
Sodium (meta)arsenite | 7784-46-5 | sc-250986 sc-250986A | 100 g 1 kg | $106.00 $765.00 | 3 | |
Sodium Arsenite is a potent inducer of the heat shock response. It enhances the function of DnaJB14 by promoting the activation of HSF1, which in turn stimulates DnaJB14 expression. | ||||||
Celastrol, Celastrus scandens | 34157-83-0 | sc-202534 | 10 mg | $155.00 | 6 | |
Celastrol is a potent inducer of the heat shock response. It enhances the function of DnaJB14 by promoting the activation of HSF1, which in turn stimulates DnaJB14 expression. | ||||||