DNA pol γ2 Activators
DNA Pol γ2 Activators encompass a diverse range of chemical compounds that indirectly enhance the functional activity of DNA polymerase gamma 2 (DNA Pol γ2), a key player in mitochondrial DNA replication and repair. These activators primarily exert their influence through pathways that bolster mitochondrial biogenesis and function, thereby indirectly necessitating increased DNA Pol γ2 activity. For instance, Resveratrol and Pterostilbene, both polyphenols, activate SIRT1, a regulator of mitochondrial biogenesis. This activation indirectly elevates the demand for DNA Pol γ2's role in mitochondrial DNA replication and maintenance. Similarly, Epigallocatechin Gallate (EGCG), found in green tea, activates the AMPK pathway, which is known to boost mitochondrial function. Enhanced mitochondrial activity could logically require more robust activity from DNA Pol γ2 to keep up with increased mitochondrial DNA replication and repair needs.
Moreover, compounds like Mitoquinone Mesylate, targeting mitochondria directly as an antioxidant, reduce oxidative stress, a factor that could indirectly augment the requirement for DNA Pol γ2 in maintaining mitochondrial DNA integrity. Nicotinamide Mononucleotide (NMN) enhances NAD+ levels, critical for mitochondrial function and, by extension, DNA Pol γ2 activity. Sulforaphane, activating the Nrf2 pathway, and compounds like Bezafibrate, activating PPARs, both contribute to improved mitochondrial function and biogenesis. This enhancement in mitochondrial health creates a scenario where the functional demand on DNA Pol γ2 is increased, given its crucial role in mitochondrial DNA upkeep. Other compounds like Metformin, Coenzyme Q10, and α-Lipoic Acid, all known for their roles in influencing mitochondrial health and bioenergetics, also indirectly contribute to the increased functional necessity of DNA Pol γ2. Each of these compounds, through their targeted effects on mitochondrial function and health, creates a biochemical environment where the activity of DNA Pol γ2 is indirectly but significantly heightened, ensuring effective mitochondrial DNA replication and repair.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Resveratrol | 501-36-0 | sc-200808 sc-200808A sc-200808B | 100 mg 500 mg 5 g | $60.00 $185.00 $365.00 | 64 | |
Resveratrol, a polyphenol, activates SIRT1 leading to enhanced mitochondrial biogenesis. DNA Pol γ2, integral in mitochondrial DNA replication and repair, may see increased functional activity due to this heightened mitochondrial genesis. | ||||||
(−)-Epigallocatechin Gallate | 989-51-5 | sc-200802 sc-200802A sc-200802B sc-200802C sc-200802D sc-200802E | 10 mg 50 mg 100 mg 500 mg 1 g 10 g | $42.00 $72.00 $124.00 $238.00 $520.00 $1234.00 | 11 | |
EGCG, a catechin in green tea, influences mitochondrial function and biogenesis through AMPK pathway activation. This, in turn, could enhance the activity of DNA Pol γ2 by increasing the demand for mitochondrial DNA replication and repair. | ||||||
Mito-Q | 444890-41-9 | sc-507441 | 5 mg | $284.00 | ||
This compound targets mitochondria and acts as an antioxidant, reducing oxidative stress. Reduced oxidative damage in mitochondria could indirectly necessitate the action of DNA Pol γ2, as it is vital for mitochondrial DNA integrity. | ||||||
β-Nicotinamide mononucleotide | 1094-61-7 | sc-212376 sc-212376A sc-212376B sc-212376C sc-212376D | 25 mg 100 mg 1 g 2 g 5 g | $92.00 $269.00 $337.00 $510.00 $969.00 | 4 | |
NMN enhances NAD+ levels, crucial for mitochondrial function and sirtuin activity. Enhanced mitochondrial function indirectly demands higher activity of DNA Pol γ2 for mitochondrial DNA maintenance. | ||||||
D,L-Sulforaphane | 4478-93-7 | sc-207495A sc-207495B sc-207495C sc-207495 sc-207495E sc-207495D | 5 mg 10 mg 25 mg 1 g 10 g 250 mg | $150.00 $286.00 $479.00 $1299.00 $8299.00 $915.00 | 22 | |
Sulforaphane, found in cruciferous vegetables, influences Nrf2 pathway, which plays a role in mitochondrial function. Improved mitochondrial function and biogenesis indirectly increase the requirement for DNA Pol γ2 activity in mitochondrial DNA maintenance. | ||||||
Elamipretide | 736992-21-5 | sc-507453 | 25 mg | $670.00 | ||
This peptide targets cardiolipin and stabilizes mitochondrial function. By enhancing mitochondrial integrity, it indirectly increases the need for functional DNA Pol γ2 in maintaining mitochondrial DNA. | ||||||
Bezafibrate | 41859-67-0 | sc-204650B sc-204650 sc-204650A sc-204650C | 500 mg 1 g 5 g 10 g | $30.00 $45.00 $120.00 $200.00 | 5 | |
Bezafibrate activates PPARs leading to improved mitochondrial function and biogenesis. This could indirectly increase the functional demand on DNA Pol γ2 due to enhanced mitochondrial DNA replication and repair needs. | ||||||
Metformin-d6, Hydrochloride | 1185166-01-1 | sc-218701 sc-218701A sc-218701B | 1 mg 5 mg 10 mg | $286.00 $806.00 $1510.00 | 1 | |
Metformin, primarily an antidiabetic drug, also influences mitochondrial biogenesis via AMPK pathway. Enhanced mitochondrial biogenesis potentially augments the functional requirement of DNA Pol γ2. | ||||||
Coenzyme Q10 | 303-98-0 | sc-205262 sc-205262A | 1 g 5 g | $70.00 $180.00 | 1 | |
CoQ10 is pivotal in mitochondrial electron transport chain, which could indirectly influence the activity of DNA Pol γ2 by modulating mitochondrial health and therefore the need for mitochondrial DNA maintenance. | ||||||
α-Lipoic Acid | 1077-28-7 | sc-202032 sc-202032A sc-202032B sc-202032C sc-202032D | 5 g 10 g 250 g 500 g 1 kg | $68.00 $120.00 $208.00 $373.00 $702.00 | 3 | |
α-Lipoic Acid, an antioxidant, is involved in mitochondrial bioenergetics. Enhanced mitochondrial function could indirectly necessitate increased activity of DNA Pol γ2 in mitochondrial DNA replication and repair. | ||||||