Date published: 2025-10-23

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DNA pol α Activators

The chemical class of DNA pol α Activators includes compounds that can indirectly influence DNA pol α function through their effects on DNA synthesis, replication stress, and DNA damage response. DNA pol α is critical for initiating DNA replication and is responsive to the cellular environment and DNA integrity.

Compounds like Hydroxyurea, Gemcitabine, and 5-Fluorouracil, by affecting nucleotide synthesis or mimicking nucleotides, could indirectly impact DNA pol α activity. These compounds alter the substrate availability or fidelity of DNA synthesis, potentially influencing DNA pol α during replication. DNA-damaging agents such as Etoposide, Cisplatin, Doxorubicin, Bleomycin, Mitomycin C, and Camptothecin can induce replication stress or damage DNA, potentially impacting DNA pol α activity. The response to DNA damage often involves increased activity of DNA repair enzymes, including DNA pol α.

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Product NameCAS #Catalog #QUANTITYPriceCitationsRATING

Caffeine

58-08-2sc-202514
sc-202514A
sc-202514B
sc-202514C
sc-202514D
5 g
100 g
250 g
1 kg
5 kg
$32.00
$66.00
$95.00
$188.00
$760.00
13
(1)

Inhibits DNA repair and may indirectly influence DNA pol α activity during DNA replication.

2′-Deoxy-2′,2′-difluorocytidine

95058-81-4sc-275523
sc-275523A
1 g
5 g
$56.00
$128.00
(1)

A nucleoside analog, can impact DNA synthesis, indirectly affecting DNA pol α.

Fluorouracil

51-21-8sc-29060
sc-29060A
1 g
5 g
$36.00
$149.00
11
(1)

A pyrimidine analog, affects DNA synthesis, potentially influencing DNA pol α.

Actinomycin D

50-76-0sc-200906
sc-200906A
sc-200906B
sc-200906C
sc-200906D
5 mg
25 mg
100 mg
1 g
10 g
$73.00
$238.00
$717.00
$2522.00
$21420.00
53
(3)

Interferes with DNA replication and transcription, potentially impacting DNA pol α.

Etoposide (VP-16)

33419-42-0sc-3512B
sc-3512
sc-3512A
10 mg
100 mg
500 mg
$32.00
$170.00
$385.00
63
(1)

Induces DNA damage, leading to replication stress that might influence DNA pol α activity.

Cisplatin

15663-27-1sc-200896
sc-200896A
100 mg
500 mg
$76.00
$216.00
101
(4)

Forms DNA adducts, leading to replication stress, potentially affecting DNA pol α.

Doxorubicin

23214-92-8sc-280681
sc-280681A
1 mg
5 mg
$173.00
$418.00
43
(3)

Induces DNA damage and could influence DNA pol α during DNA replication.

Bleomycin Sulfate

9041-93-4sc-200134
sc-200134A
sc-200134B
sc-200134C
10 mg
50 mg
100 mg
500 mg
$206.00
$612.00
$1020.00
$2856.00
38
(3)

Causes DNA breaks, potentially affecting DNA pol α activity in response to DNA damage.

Mitomycin C

50-07-7sc-3514A
sc-3514
sc-3514B
2 mg
5 mg
10 mg
$65.00
$99.00
$140.00
85
(5)

Crosslinks DNA, influencing DNA replication and potentially DNA pol α.

Camptothecin

7689-03-4sc-200871
sc-200871A
sc-200871B
50 mg
250 mg
100 mg
$57.00
$182.00
$92.00
21
(2)

Inhibits DNA topoisomerase I, causing replication stress that could impact DNA pol α.