DNA pol α Activators
The chemical class of DNA pol α Activators includes compounds that can indirectly influence DNA pol α function through their effects on DNA synthesis, replication stress, and DNA damage response. DNA pol α is critical for initiating DNA replication and is responsive to the cellular environment and DNA integrity.
Compounds like Hydroxyurea, Gemcitabine, and 5-Fluorouracil, by affecting nucleotide synthesis or mimicking nucleotides, could indirectly impact DNA pol α activity. These compounds alter the substrate availability or fidelity of DNA synthesis, potentially influencing DNA pol α during replication. DNA-damaging agents such as Etoposide, Cisplatin, Doxorubicin, Bleomycin, Mitomycin C, and Camptothecin can induce replication stress or damage DNA, potentially impacting DNA pol α activity. The response to DNA damage often involves increased activity of DNA repair enzymes, including DNA pol α.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Caffeine | 58-08-2 | sc-202514 sc-202514A sc-202514B sc-202514C sc-202514D | 50 g 100 g 250 g 1 kg 5 kg | $33.00 $67.00 $97.00 $192.00 $775.00 | 13 | |
Inhibits DNA repair and may indirectly influence DNA pol α activity during DNA replication. | ||||||
2′-Deoxy-2′,2′-difluorocytidine | 95058-81-4 | sc-275523 sc-275523A | 1 g 5 g | $56.00 $128.00 | ||
A nucleoside analog, can impact DNA synthesis, indirectly affecting DNA pol α. | ||||||
Fluorouracil | 51-21-8 | sc-29060 sc-29060A | 1 g 5 g | $37.00 $152.00 | 11 | |
A pyrimidine analog, affects DNA synthesis, potentially influencing DNA pol α. | ||||||
Actinomycin D | 50-76-0 | sc-200906 sc-200906A sc-200906B sc-200906C sc-200906D | 5 mg 25 mg 100 mg 1 g 10 g | $74.00 $243.00 $731.00 $2572.00 $21848.00 | 53 | |
Interferes with DNA replication and transcription, potentially impacting DNA pol α. | ||||||
Etoposide (VP-16) | 33419-42-0 | sc-3512B sc-3512 sc-3512A | 10 mg 100 mg 500 mg | $51.00 $231.00 $523.00 | 63 | |
Induces DNA damage, leading to replication stress that might influence DNA pol α activity. | ||||||
Cisplatin | 15663-27-1 | sc-200896 sc-200896A | 100 mg 500 mg | $138.00 $380.00 | 101 | |
Forms DNA adducts, leading to replication stress, potentially affecting DNA pol α. | ||||||
Doxorubicin | 23214-92-8 | sc-280681 sc-280681A | 1 mg 5 mg | $176.00 $426.00 | 43 | |
Induces DNA damage and could influence DNA pol α during DNA replication. | ||||||
Bleomycin Sulfate | 9041-93-4 | sc-200134 sc-200134A sc-200134B sc-200134C | 10 mg 50 mg 100 mg 500 mg | $210.00 $624.00 $1040.00 $2913.00 | 38 | |
Causes DNA breaks, potentially affecting DNA pol α activity in response to DNA damage. | ||||||
Mitomycin C | 50-07-7 | sc-3514A sc-3514 sc-3514B | 2 mg 5 mg 10 mg | $66.00 $101.00 $143.00 | 85 | |
Crosslinks DNA, influencing DNA replication and potentially DNA pol α. | ||||||
Camptothecin | 7689-03-4 | sc-200871 sc-200871A sc-200871B | 50 mg 250 mg 100 mg | $58.00 $186.00 $94.00 | 21 | |
Inhibits DNA topoisomerase I, causing replication stress that could impact DNA pol α. | ||||||