DES2 Activators
DES2 activators encompass a range of compounds that enhance the functional activity of DES2 through diverse mechanisms within cellular signaling pathways. Forskolin, by elevating cAMP, indirectly stimulates PKA, which can phosphorylate substrates involved in DES2-mediated processes. Genistein, through tyrosine kinase inhibition, relieves negative regulation on DES2, facilitating its cellular roles. S1P, via its receptor-mediated signaling, can strengthen DES2 activity by influencing cell proliferation and survival pathways.
Thapsigargin's mode of action is via the elevation of cytosolic calcium levels, which can activate calcium-dependent signaling pathways, indirectly promoting DES2 activity. PMA's activation of PKC leads to phosphorylation of regulatory proteins of DES2, enhancing its activity. EGCG, by inhibiting kinases, prevents negative regulation of DES2, offering a boost to its functional capacity.
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $78.00 $153.00 $740.00 $1413.00 $2091.00 | 73 | |
Forskolin directly stimulates adenylyl cyclase, leading to increased levels of cyclic AMP (cAMP) in cells. This elevation in cAMP activates protein kinase A (PKA), which can subsequently phosphorylate substrates that augment the functional activity of DES2 in various cellular processes. | ||||||
Genistein | 446-72-0 | sc-3515 sc-3515A sc-3515B sc-3515C sc-3515D sc-3515E sc-3515F | 100 mg 500 mg 1 g 5 g 10 g 25 g 100 g | $45.00 $164.00 $200.00 $402.00 $575.00 $981.00 $2031.00 | 46 | |
Genistein is a tyrosine kinase inhibitor that can upregulate DES2 activity by inhibiting tyrosine phosphorylation, which may otherwise negatively regulate DES2-associated pathways, thereby potentially promoting DES2's functional roles in cells. | ||||||
D-erythro-Sphingosine-1-phosphate | 26993-30-6 | sc-201383 sc-201383D sc-201383A sc-201383B sc-201383C | 1 mg 2 mg 5 mg 10 mg 25 mg | $165.00 $322.00 $570.00 $907.00 $1727.00 | 7 | |
Sphingosine-1-phosphate (S1P) engages in S1P receptor-mediated signaling. Its binding to S1P receptors can initiate downstream effects that bolster the functional activity of DES2 through regulation of cellular activities such as proliferation and survival in which DES2 participates. | ||||||
PMA | 16561-29-8 | sc-3576 sc-3576A sc-3576B sc-3576C sc-3576D | 1 mg 5 mg 10 mg 25 mg 100 mg | $41.00 $132.00 $214.00 $500.00 $948.00 | 119 | |
PMA is a potent activator of protein kinase C (PKC). Activation of PKC can lead to phosphorylation events that promote the activity of DES2 by influencing proteins that regulate or interact with DES2 within cellular pathways. | ||||||
(−)-Epigallocatechin Gallate | 989-51-5 | sc-200802 sc-200802A sc-200802B sc-200802C sc-200802D sc-200802E | 10 mg 50 mg 100 mg 500 mg 1 g 10 g | $43.00 $73.00 $126.00 $243.00 $530.00 $1259.00 | 11 | |
EGCG acts as a kinase inhibitor and can potentiate DES2 activity by inhibiting certain kinases that negatively regulate DES2 signaling pathways, thus indirectly contributing to the enhancement of DES2's functional roles within the cell. | ||||||
LY 294002 | 154447-36-6 | sc-201426 sc-201426A | 5 mg 25 mg | $123.00 $400.00 | 148 | |
LY294002 is an inhibitor of phosphoinositide 3-kinases (PI3K) that can promote DES2 functionality by attenuating the PI3K/Akt pathway, which, when overactive, may counteract the pathways positively regulated by DES2. | ||||||
Wortmannin | 19545-26-7 | sc-3505 sc-3505A sc-3505B | 1 mg 5 mg 20 mg | $67.00 $223.00 $425.00 | 97 | |
Wortmannin, like LY294002, is a PI3K inhibitor. It enhances DES2 function through the same mechanism—by inhibiting the PI3K/Akt pathway, which can be antagonistic to the role of DES2 in the cell. | ||||||
SB 203580 | 152121-47-6 | sc-3533 sc-3533A | 1 mg 5 mg | $90.00 $349.00 | 284 | |
SB203580 is a selective inhibitor of p38 MAP kinase. By inhibiting p38 MAPK, it may shift the balance of signaling towards pathways in which DES2 is active, thus selectively enhancing the activity of DES2. | ||||||
A23187 | 52665-69-7 | sc-3591 sc-3591B sc-3591A sc-3591C | 1 mg 5 mg 10 mg 25 mg | $55.00 $131.00 $203.00 $317.00 | 23 | |
A23187 (Calcimycin) is a calcium ionophore known to increase intracellular calcium levels. This rise in calcium can indirectly stimulate DES2 activity through the activation of calcium-dependent proteins and signaling pathways that interact with DES2. | ||||||
Staurosporine | 62996-74-1 | sc-3510 sc-3510A sc-3510B | 100 µg 1 mg 5 mg | $82.00 $153.00 $396.00 | 113 | |
Staurosporine is a broad-spectrum kinase inhibitor. It may heighten DES2's activity by inhibiting various kinases that negatively regulate DES2's signaling pathways, thereby allowing for an upregulation of DES2's functional roles in cells. | ||||||