Date published: 2026-2-14

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DES2 Inhibitors

The chemical class known as DES2 inhibitors encompasses a variety of compounds that can modulate the activity of DES2, an enzyme involved in specific biological processes. These inhibitors are significant because they can impact the pathways regulated by DES2, affecting its role in cellular physiology and biochemistry. The methods of inhibition vary; some inhibitors may directly interact with the enzyme, impairing its catalytic function, while others might indirectly influence the enzyme's activity or expression by modulating related metabolic pathways, signaling networks, or substrate availability.

The development and study of DES2 inhibitors are complex and necessitate a deep understanding of the enzyme's biological context, including its structure, function, and interaction with other cellular components. These inhibitors are important for probing the fundamental aspects of DES2's roles in cells and hold implications for conditions where the enzyme's activity is dysregulated. Inhibiting DES2 could lead to changes in specific cellular processes or pathways where this enzyme plays a critical role. As such, DES2 inhibitors might be useful in research settings to dissect the enzyme's function or as leads in development. However, crafting these inhibitors requires not only a detailed knowledge of DES2's mechanism of action but also an understanding of the broader cellular consequences of modulating its activity. Each inhibitor's efficacy, selectivity, and overall cellular impact need thorough investigation in biochemical and cellular contexts. As research progresses, the study of DES2 inhibitors is likely to provide valuable insights into the enzyme's function and open up new avenues for understanding related cellular processes. Such research is crucial for advancing our comprehension of biological systems and developing novel strategies for intervention in enzyme-related processes.

SEE ALSO...

Product NameCAS #Catalog #QUANTITYPriceCitationsRATING

Myriocin (ISP-1)

35891-70-4sc-201397
10 mg
$150.00
8
(2)

Myriocin is an inhibitor of serine palmitoyltransferase and could possibly inhibit DES2 by decreasing the substrate availability crucial for its activity in sphingolipid biosynthesis.

Fumonisin B1

116355-83-0sc-201395
sc-201395A
1 mg
5 mg
$200.00
$680.00
18
(1)

Fumonisin B1 inhibits ceramide synthase and could possibly inhibit DES2 by disrupting sphingolipid biosynthesis, impacting the pathway and substrate levels relevant to DES2 function.

Cerulenin (synthetic)

17397-89-6sc-200827
sc-200827A
sc-200827B
5 mg
10 mg
50 mg
$161.00
$312.00
$1210.00
9
(1)

Cerulenin inhibits fatty acid synthase and could possibly inhibit DES2 by altering lipid profiles and indirectly changing the substrate availability or lipid environment for DES2 activity.

Brefeldin A

20350-15-6sc-200861C
sc-200861
sc-200861A
sc-200861B
1 mg
5 mg
25 mg
100 mg
$31.00
$53.00
$124.00
$374.00
25
(3)

PDMP inhibits glucosylceramide synthase and could possibly inhibit DES2 by influencing the overall sphingolipid metabolism and affecting DES2's role or activity in the pathway.

C75 (racemic)

191282-48-1sc-202511
sc-202511A
sc-202511B
1 mg
5 mg
10 mg
$72.00
$206.00
$290.00
9
(1)

C75, a fatty acid synthase inhibitor, could possibly inhibit DES2 by affecting overall lipid synthesis and profiles, potentially altering the cellular lipid composition or metabolism relevant to DES2.

Cyclosporin A

59865-13-3sc-3503
sc-3503-CW
sc-3503A
sc-3503B
sc-3503C
sc-3503D
100 mg
100 mg
500 mg
10 g
25 g
100 g
$63.00
$92.00
$250.00
$485.00
$1035.00
$2141.00
69
(5)

Cyclosporin A has various cellular effects and could possibly inhibit DES2 by influencing lipid metabolism or cellular processes that regulate DES2 activity.

Thapsigargin

67526-95-8sc-24017
sc-24017A
1 mg
5 mg
$136.00
$446.00
114
(2)

Thapsigargin disrupts calcium homeostasis and could possibly inhibit DES2 by affecting various cellular processes, including lipid metabolism, potentially impacting DES2 activity.

Tipifarnib

192185-72-1sc-364637
10 mg
$720.00
(0)

Tipifarnib, as a farnesyltransferase inhibitor, could possibly inhibit DES2 by altering protein prenylation and membrane association, potentially affecting DES2's function or localization.

Simvastatin

79902-63-9sc-200829
sc-200829A
sc-200829B
sc-200829C
50 mg
250 mg
1 g
5 g
$31.00
$89.00
$135.00
$443.00
13
(1)

Simvastatin could possibly inhibit DES2 by affecting cholesterol biosynthesis and altering membrane composition, potentially changing the environment or substrate availability for DES2.