Derlin-3 Activators
Derlin-3 activators are compounds that can enhance the activity of Derlin-3 by affecting specific cellular or biochemical processes. For instance, compounds like MG132, Epoxomicin, Bortezomib, Carfilzomib, ALLN, and Lactacystin are proteasome inhibitors that prevent the degradation of misfolded proteins. By inhibiting the proteasome, these compounds can increase the cellular accumulation of Derlin-3-associated proteins, indirectly enhancing the functional activity of Derlin-3. This enhancement is crucial for the unwinding of protein structures, an essential process in protein metabolism.
Another category of Derlin-3 activators, such as Chloroquine, 3-Methyladenine, Concanamycin A, NH4Cl, Bafilomycin A1, and Eeyarestatin I, operate through similar mechanisms, although via different targets. They either inhibit autophagy or V-ATPase, preventing the degradation of proteins via the autophagy-lysosome pathway or in the lysosome, respectively. By doing so, these compounds can enhance theaccumulation of Derlin-3-associated proteins, indirectly enhancing the functional activity of Derlin-3. This increased abundance of Derlin-3-associated proteins is critical for the protein's role in the endoplasmic reticulum-associated degradation (ERAD) pathway, where it assists in recognizing and exporting misfolded proteins from the ER. In particular, Eeyarestatin I, an inhibitor of ERAD, can lead to an accumulation of Derlin-3-associated proteins in the ER, further enhancing Derlin-3 activity. This is significant as it underscores the role of Derlin-3 in maintaining protein homeostasis within the cell, particularly in the context of the ER.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
MG-132 [Z-Leu- Leu-Leu-CHO] | 133407-82-6 | sc-201270 sc-201270A sc-201270B | 5 mg 25 mg 100 mg | $60.00 $265.00 $1000.00 | 163 | |
MG132 is a proteasome inhibitor that prevents the degradation of misfolded proteins. By inhibiting the proteasome, MG132 can increase the cellular accumulation of Derlin-3-associated proteins, indirectly enhancing the functional activity of Derlin-3. | ||||||
Epoxomicin | 134381-21-8 | sc-201298C sc-201298 sc-201298A sc-201298B | 50 µg 100 µg 250 µg 500 µg | $137.00 $219.00 $449.00 $506.00 | 19 | |
Epoxomicin is a potent, irreversible, and selective proteasome inhibitor. It prevents the degradation of misfolded proteins, which can increase the accumulation and thus the functional activity of Derlin-3. | ||||||
Bortezomib | 179324-69-7 | sc-217785 sc-217785A | 2.5 mg 25 mg | $135.00 $1085.00 | 115 | |
Bortezomib is a proteasome inhibitor that prevents the breakdown of misfolded proteins. By doing so, it can enhance the accumulation of proteins associated with Derlin-3, indirectly enhancing its functional activity. | ||||||
Carfilzomib | 868540-17-4 | sc-396755 | 5 mg | $41.00 | ||
Carfilzomib is a selective proteasome inhibitor that prevents the degradation of misfolded proteins. By doing so, it enhances the accumulation of proteins associated with Derlin-3, indirectly enhancing its functional activity. | ||||||
Lactacystin | 133343-34-7 | sc-3575 sc-3575A | 200 µg 1 mg | $188.00 $575.00 | 60 | |
Lactacystin is a specific and irreversible proteasome inhibitor. By inhibiting the proteasome, it prevents the degradation of misfolded proteins, thus indirectly enhancing the functional activity of Derlin-3. | ||||||
Chloroquine | 54-05-7 | sc-507304 | 250 mg | $69.00 | 2 | |
Chloroquine is an autophagy inhibitor that prevents the degradation of proteins via the autophagy-lysosome pathway. This can potentially increase the accumulation of Derlin-3-associated proteins, indirectly enhancing the functional activity of Derlin-3. | ||||||
Autophagy Inhibitor, 3-MA | 5142-23-4 | sc-205596 sc-205596A | 50 mg 500 mg | $65.00 $261.00 | 113 | |
3-Methyladenine is a potent inhibitor of autophagy. By inhibiting autophagy, it prevents the degradation of proteins, which can result in an increase in the accumulation of Derlin-3-associated proteins, indirectly enhancing the activity of Derlin-3. | ||||||
Concanamycin A | 80890-47-7 | sc-202111 sc-202111A sc-202111B sc-202111C | 50 µg 200 µg 1 mg 5 mg | $66.00 $167.00 $673.00 $2601.00 | 109 | |
Concanamycin A is a potent and specific inhibitor of the vacuolar type H+-ATPase (V-ATPase). By inhibiting V-ATPase, it prevents the degradation of proteins in the lysosome, potentially leading to an increase in the accumulation of Derlin-3-associated proteins. | ||||||
Ammonium Chloride | 12125-02-9 | sc-202936 sc-202936A sc-202936B | 25 g 500 g 2.5 kg | $39.00 $55.00 $150.00 | 4 | |
NH4Cl is a lysosomotropic agent that prevents the acidification of lysosomes and thus inhibits protein degradation. This can lead to increased accumulation of Derlin-3-associated proteins, indirectly enhancing the functional activity of Derlin-3. | ||||||
Bafilomycin A1 | 88899-55-2 | sc-201550 sc-201550A sc-201550B sc-201550C | 100 µg 1 mg 5 mg 10 mg | $98.00 $255.00 $765.00 $1457.00 | 280 | |
Bafilomycin A1 is a potent inhibitor of V-ATPase, preventing the acidification of lysosomes and inhibiting protein degradation. This can potentially increase the accumulation of Derlin-3-associated proteins, indirectly enhancing the activity of Derlin-3. | ||||||