Dematin Inhibitors
Dematin inhibitors belong to a class of chemical compounds specifically designed to target and modulate the activity of the Dematin protein. Dematin, also known as erythrocyte dematin or band 4.9 protein, is an essential cytoskeletal protein found in red blood cells (erythrocytes). It plays a pivotal role in maintaining the structural integrity and flexibility of erythrocytes, crucial for their function in oxygen transport. Dematin accomplishes this by interacting with the actin cytoskeleton and regulating the organization of membrane proteins. Inhibitors designed to target Dematin are primarily employed in molecular and cellular biology research to elucidate the functional properties and regulatory mechanisms associated with this critical protein.
The development of Dematin inhibitors involves various approaches, including biochemical, biophysical, and structural techniques, to identify or design molecules that can selectively interact with Dematin and modulate its activity. By inhibiting Dematin, these compounds can potentially disrupt its binding to actin and its role in maintaining erythrocyte membrane structure. Researchers use Dematin inhibitors to explore the intricate roles played by Dematin in erythrocyte biology and the broader context of cytoskeletal regulation.
SEE ALSO...
Items 1 to 10 of 11 total
Display:
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Cordycepin | 73-03-0 | sc-203902 | 10 mg | $101.00 | 5 | |
Cordycepin, a nucleoside analogue, may inhibit RNA polymerase and result in the reduction of mRNA synthesis, potentially leading to decreased dematin expression. | ||||||
Camptothecin | 7689-03-4 | sc-200871 sc-200871A sc-200871B | 50 mg 250 mg 100 mg | $58.00 $186.00 $94.00 | 21 | |
By inhibiting topoisomerase I, camptothecin can cause DNA damage and could indirectly reduce transcription of various genes, including that of dematin. | ||||||
Mitomycin C | 50-07-7 | sc-3514A sc-3514 sc-3514B | 2 mg 5 mg 10 mg | $66.00 $101.00 $143.00 | 85 | |
As an alkylating agent, Mitomycin C can crosslink DNA, potentially leading to reduced transcription and subsequent decreased expression of proteins like dematin. | ||||||
Actinomycin D | 50-76-0 | sc-200906 sc-200906A sc-200906B sc-200906C sc-200906D | 5 mg 25 mg 100 mg 1 g 10 g | $74.00 $243.00 $731.00 $2572.00 $21848.00 | 53 | |
This compound intercalates into DNA, inhibiting RNA polymerase and possibly decreasing gene expression, including that of dematin. | ||||||
Rifampicin | 13292-46-1 | sc-200910 sc-200910A sc-200910B sc-200910C | 1 g 5 g 100 g 250 g | $97.00 $328.00 $676.00 $1467.00 | 6 | |
Known to bind to bacterial RNA polymerase, Rifampicin might decrease gene expression if it affects eukaryotic polymerases, reducing dematin production. | ||||||
α-Amanitin | 23109-05-9 | sc-202440 sc-202440A | 1 mg 5 mg | $269.00 $1050.00 | 26 | |
This inhibitor of RNA polymerase II can reduce mRNA production for genes including dematin, leading to lower protein levels. | ||||||
Doxorubicin | 23214-92-8 | sc-280681 sc-280681A | 1 mg 5 mg | $176.00 $426.00 | 43 | |
An anthracycline that intercalates with DNA and can inhibit macromolecular biosynthesis, potentially decreasing dematin expression. | ||||||
Aphidicolin | 38966-21-1 | sc-201535 sc-201535A sc-201535B | 1 mg 5 mg 25 mg | $84.00 $306.00 $1104.00 | 30 | |
A specific inhibitor of DNA polymerase α and δ, it can inhibit DNA synthesis and potentially reduce the expression of genes like dematin. | ||||||
Etoposide (VP-16) | 33419-42-0 | sc-3512B sc-3512 sc-3512A | 10 mg 100 mg 500 mg | $51.00 $231.00 $523.00 | 63 | |
By inhibiting topoisomerase II, etoposide can cause DNA damage, which might lead to a general reduction in gene expression, including that of dematin. | ||||||
Bleomycin | 11056-06-7 | sc-507293 | 5 mg | $275.00 | 5 | |
Causes DNA cleavage and could indirectly lower the expression of many genes, including those coding for dematin, by inducing DNA damage responses. | ||||||