Deltex (DTX; E3 ubiquitin ligase) Inhibitors
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Semagacestat | 425386-60-3 | sc-364614 sc-364614A | 10 mg 50 mg | $350.00 $1200.00 | 1 | |
Gamma-Secretase Inhibitors block the cleavage of the Notch receptor, indirectly affecting the role of Deltex in the pathway. | ||||||
DAPT | 208255-80-5 | sc-201315 sc-201315A sc-201315B sc-201315C | 5 mg 25 mg 100 mg 1 g | $40.00 $120.00 $480.00 $2141.00 | 47 | |
Gamma-Secretase Inhibitors block the cleavage of the Notch receptor, indirectly affecting the role of Deltex in the pathway. | ||||||
LY411575 | 209984-57-6 | sc-364529 sc-364529A | 10 mg 50 mg | $198.00 $473.00 | 6 | |
Gamma-Secretase Inhibitors block the cleavage of the Notch receptor, indirectly affecting the role of Deltex in the pathway. | ||||||
Bortezomib | 179324-69-7 | sc-217785 sc-217785A | 2.5 mg 25 mg | $135.00 $1085.00 | 115 | |
By inhibiting the proteasome, these compounds can affect the degradation of ubiquitinated proteins, indirectly influencing Deltex E3 ubiquitin ligase activity. A proteasome inhibitor that can lead to the accumulation of ubiquitinated proteins, indirectly affecting E3 ligase activity. | ||||||
Ganetespib | 888216-25-9 | sc-364496 sc-364496A | 10 mg 250 mg | $273.00 $1040.00 | ||
HSP90 stabilizes many proteins, including those involved in the Notch pathway. Its inhibition can indirectly affect Deltex function. | ||||||
Ikarugamycin | 36531-78-9 | sc-202179 | 500 µg | $189.00 | 4 | |
A compound that disrupts clathrin-mediated endocytosis, potentially affecting the internalization and recycling of the Notch receptor and indirectly influencing Deltex activity. | ||||||
Ubiquitin E1 Inhibitor, PYR-41 | 418805-02-4 | sc-358737 | 25 mg | $360.00 | 4 | |
The first cell-permeable inhibitor known to directly inhibit the ubiquitin-activating enzyme E1, indirectly affecting E3 ligase activity. | ||||||
MLN 4924 | 905579-51-3 | sc-484814 | 1 mg | $286.00 | 1 | |
An inhibitor of NEDD8-activating enzyme, affecting the activity of cullin-RING ligases (CRLs), a family of E3 ubiquitin ligases. | ||||||
Leptomycin B | 87081-35-4 | sc-358688 sc-358688A sc-358688B | 50 µg 500 µg 2.5 mg | $107.00 $416.00 $1248.00 | 35 | |
An inhibitor of exportin 1 (CRM1), indirectly affecting the function of certain E3 ligases by altering the nuclear-cytoplasmic transport of their substrates or regulators. | ||||||