DECR2 Activators
The activation of DECR2 through indirect means would involve influencing the expression and function of this protein via the modulation of cellular signaling pathways, particularly those regulated by PPARs. PPARs are nuclear hormone receptors that, when activated, can induce the transcription of genes involved in lipid metabolism, including those encoding enzymes for the peroxisomal beta-oxidation pathway. Substances like fibrates (e.g., bezafibrate, fenofibrate, clofibrate, and gemfibrozil) are known to be potent activators of PPARα, leading to increased transcription of peroxisomal enzymes, potentially resulting in elevated DECR2 levels and activity. The specific action of fibrates involves their binding to PPARα, which heterodimerizes with the retinoid X receptor (RXR) and binds to peroxisome proliferator response elements (PPREs) in the promoter region of target genes, promoting their expression.
Moreover, fatty acids and their derivatives can serve as natural ligands for PPARs. Compounds like leukotriene B4, palmitic acid, linoleic acid, oleic acid, α-linolenic acid, and docosahexaenoic acid can modulate the activity of PPARs and thereby influence the expression of DECR2. The role of PPARs in peroxisomal proliferation and beta-oxidation is significant, as activation of these receptors upregulates the entire pathway, which includes the augmentation of DECR2 activity.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Bezafibrate | 41859-67-0 | sc-204650B sc-204650 sc-204650A sc-204650C | 500 mg 1 g 5 g 10 g | $31.00 $46.00 $122.00 $204.00 | 5 | |
Bezafibrate is a peroxisome proliferator-activated receptor (PPAR) agonist that can induce peroxisome proliferation, thereby potentially increasing the expression of peroxisomal enzymes including DECR2. | ||||||
Fenofibrate | 49562-28-9 | sc-204751 | 5 g | $41.00 | 9 | |
Fenofibrate, another PPAR agonist, can similarly lead to the induction of genes encoding for enzymes involved in fatty acid oxidation, which could enhance the levels and activity of DECR2. | ||||||
Clofibrate | 637-07-0 | sc-200721 | 1 g | $33.00 | ||
Clofibrate is also known to act on PPARs and could contribute to the upregulation of peroxisomal enzymes, possibly resulting in elevated DECR2 activity. | ||||||
LTB4 (Leukotriene B4) | 71160-24-2 | sc-201043 | 50 µg | $374.00 | 4 | |
Leukotriene B4 is a fatty acid derivative that can act as a PPARα agonist, leading to the transcription of peroxisomal enzymes and could increase DECR2 activity. | ||||||
WY 14643 | 50892-23-4 | sc-203314 | 50 mg | $136.00 | 7 | |
Wy-14643 is a potent PPARα activator that can promote the expression of enzymes involved in the peroxisomal beta-oxidation pathway, thereby potentially enhancing DECR2 activity. | ||||||
Gemfibrozil | 25812-30-0 | sc-204764 sc-204764A | 5 g 25 g | $66.00 $267.00 | 2 | |
Gemfibrozil acts as a PPARα agonist, which may result in the induction of fatty acid metabolism enzymes in peroxisomes, including DECR2. | ||||||
L-Tyrosine | 60-18-4 | sc-473512 sc-473512A sc-473512B sc-473512C | 100 g 250 g 1 kg 5 kg | $52.00 $213.00 $1670.00 $8328.00 | 1 | |
This compound has been shown to act as a PPAR agonist, potentially inducing the expression of DECR2 as part of the peroxisomal enzyme repertoire. | ||||||
Palmitic Acid | 57-10-3 | sc-203175 sc-203175A | 25 g 100 g | $114.00 $286.00 | 2 | |
Palmitic acid is a fatty acid that, at specific concentrations, can enhance peroxisomal proliferation and could, therefore, increase DECR2 expression as part of the overall upregulation of fatty acid metabolism. | ||||||
Linoleic Acid | 60-33-3 | sc-200788 sc-200788A sc-200788B sc-200788C | 100 mg 1 g 5 g 25 g | $34.00 $64.00 $166.00 $281.00 | 4 | |
Linoleic acid, a polyunsaturated fatty acid, might enhance the transcription of genes coding for peroxisomal enzymes through PPAR activation, thereby potentially increasing DECR2 activity. | ||||||
Oleic Acid | 112-80-1 | sc-200797C sc-200797 sc-200797A sc-200797B | 1 g 10 g 100 g 250 g | $37.00 $104.00 $580.00 $1196.00 | 10 | |
Oleic acid is a monounsaturated fatty acid that could lead to the activation of peroxisomal gene expression, possibly including DECR2, as a component of the cellular response to changes in lipid composition. | ||||||