DDX50 Activators
DDX50 activators encompass a diverse group of compounds that interact with cellular energy balance, stress response, and RNA metabolism, indirectly influencing the activity of this RNA helicase. This set includes agents that increase intracellular ATP levels, such as adenosine triphosphate itself, ensuring the energy supply for the ATP-dependent helicase activity of DDX50. Compounds like actinomycin D and 5-azacytidine alter the transcription landscape, potentially creating a higher demand for RNA processing and, in turn, DDX50 function. Caffeine, by affecting cellular cAMP levels, may indirectly influence ATP availability and thereby DDX50 activity.
Moreover, inhibitors of nuclear export and protein folding such as Leptomycin B and MG132, respectively, could lead to an accumulation of RNA within the nucleus, thus necessitating increased DDX50 activity for RNA processing and management. Menadione and sodium arsenite, by inducing oxidative stress, may trigger a cellular response that involves the upregulation of RNA helicases including DDX50. Geldanamycin and its derivative 17-AAG target Hsp90 and provoke a heat shock response, which can include the activation of RNA helicases like DDX50 to manage stress-induced RNA dysregulation. Lastly, compounds that induce various forms of cellular stress, such as beta-lapachone and tunicamycin, might lead to enhanced DDX50 activity as the cell attempts to mitigate the effects of stress on RNA metabolism.
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Items 1 to 10 of 12 total
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Adenosine 5′-Triphosphate, disodium salt | 987-65-5 | sc-202040 sc-202040A | 1 g 5 g | $38.00 $74.00 | 9 | |
ATP is the primary energy currency of the cell and is required for the helicase activity of DDX50. An increase in intracellular ATP can directly enhance the catalytic activity of DDX50 as it provides the necessary energy for helicase function. | ||||||
Actinomycin D | 50-76-0 | sc-200906 sc-200906A sc-200906B sc-200906C sc-200906D | 5 mg 25 mg 100 mg 1 g 10 g | $73.00 $238.00 $717.00 $2522.00 $21420.00 | 53 | |
Actinomycin D binds to DNA at the transcription initiation complex and inhibits RNA polymerase, which can lead to the accumulation of RNA precursors and potentially increase the demand for DDX50 activity in RNA processing. | ||||||
Caffeine | 58-08-2 | sc-202514 sc-202514A sc-202514B sc-202514C sc-202514D | 5 g 100 g 250 g 1 kg 5 kg | $32.00 $66.00 $95.00 $188.00 $760.00 | 13 | |
Caffeine acts as a phosphodiesterase inhibitor, leading to increased cAMP levels that can modulate cellular energy balance, potentially enhancing the energy supply (ATP) for DDX50 activity. | ||||||
5-Azacytidine | 320-67-2 | sc-221003 | 500 mg | $280.00 | 4 | |
An inhibitor of DNA methyltransferase that causes DNA demethylation and can increase transcriptional activity, potentially raising the demand for RNA helicases like DDX50. | ||||||
Leptomycin B | 87081-35-4 | sc-358688 sc-358688A sc-358688B | 50 µg 500 µg 2.5 mg | $105.00 $408.00 $1224.00 | 35 | |
An inhibitor of nuclear export that leads to the accumulation of RNA and proteins in the nucleus, which may increase the need for RNA processing and, consequently, DDX50 activity. | ||||||
MG-132 [Z-Leu- Leu-Leu-CHO] | 133407-82-6 | sc-201270 sc-201270A sc-201270B | 5 mg 25 mg 100 mg | $56.00 $260.00 $980.00 | 163 | |
A proteasome inhibitor that can lead to the accumulation of misfolded proteins, thus increasing cellular stress and potentially upregulating RNA helicase activity as part of the stress response. | ||||||
Vitamin K3 | 58-27-5 | sc-205990B sc-205990 sc-205990A sc-205990C sc-205990D | 5 g 10 g 25 g 100 g 500 g | $25.00 $35.00 $46.00 $133.00 $446.00 | 3 | |
A vitamin K analog that can induce oxidative stress, potentially enhancing the need for DDX50 activity in the management of stress-related RNA metabolism. | ||||||
Sodium (meta)arsenite | 7784-46-5 | sc-250986 sc-250986A | 100 g 1 kg | $106.00 $765.00 | 3 | |
Induces oxidative stress and heat shock protein response, potentially enhancing the demand for RNA helicases like DDX50 as part of the cellular adaptive mechanisms. | ||||||
Geldanamycin | 30562-34-6 | sc-200617B sc-200617C sc-200617 sc-200617A | 100 µg 500 µg 1 mg 5 mg | $38.00 $58.00 $102.00 $202.00 | 8 | |
An Hsp90 inhibitor that can upregulate the heat shock response, possibly leading to increased DDX50 activity to manage stress-induced RNA metabolic changes. | ||||||
17-AAG | 75747-14-7 | sc-200641 sc-200641A | 1 mg 5 mg | $66.00 $153.00 | 16 | |
Similar to geldanamycin, it inhibits Hsp90 affecting the heat shock protein response and could indirectly enhance DDX50 activity during the stress response. | ||||||