DDX35 Activators
DDX35 activators are compounds that can enhance the activity of DDX35 by affecting specific cellular or biochemical processes. For instance, compounds like adenosine, forskolin, and epinephrine elevate intracellular cAMP levels. Elevated cAMP levels lead to the activation of cAMP-dependent protein kinase A (PKA). PKA can then phosphorylate DDX35, enhancing its helicase activity. This activation is crucial for the unwinding of RNA structures, an essential process in RNA metabolism.
Another category of DDX35 activators, such as isoproterenol, caffeine, rolipram, and IBMX, operate through similar mechanisms, although via different targets. They either stimulate adrenergic receptors or inhibit phosphodiesterases to increase cAMP levels. In addition, compounds like dibutyryl-cAMP, Sp-cAMPS, and bucladesine are cell-permeable cAMP analogs that directly activate PKA, offering another route for the activation of DDX35. H-89, a PKA inhibitor, can paradoxically enhance DDX35 activity by increasing PKA activity through feedback inhibition.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Adenosine | 58-61-7 | sc-291838 sc-291838A sc-291838B sc-291838C sc-291838D sc-291838E sc-291838F | 1 g 5 g 100 g 250 g 1 kg 5 kg 10 kg | $34.00 $48.00 $300.00 $572.00 $1040.00 $2601.00 $4682.00 | 1 | |
Adenosine, a purine nucleoside, elevates cAMP levels. Increased cAMP activates protein kinase A (PKA), which can phosphorylate proteins like DDX35, enhancing its helicase activity. | ||||||
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $78.00 $153.00 $740.00 $1413.00 $2091.00 | 73 | |
Forskolin is a potent adenylate cyclase activator that increases intracellular cAMP levels. Higher cAMP levels can activate PKA, which in turn can phosphorylate DDX35, enhancing its functional activity. | ||||||
(−)-Epinephrine | 51-43-4 | sc-205674 sc-205674A sc-205674B sc-205674C sc-205674D | 1 g 5 g 10 g 100 g 1 kg | $41.00 $104.00 $201.00 $1774.00 $16500.00 | ||
Epinephrine, a catecholamine, stimulates adrenergic receptors, increasing cAMP levels and activating PKA. Activated PKA can phosphorylate DDX35, thereby enhancing its activity. | ||||||
Isoproterenol Hydrochloride | 51-30-9 | sc-202188 sc-202188A | 100 mg 500 mg | $28.00 $38.00 | 5 | |
Isoproterenol is a synthetic catecholamine that elevates cAMP levels through stimulation of beta-adrenergic receptors, leading to PKA activation. PKA can phosphorylate DDX35, enhancing its functional activity. | ||||||
Caffeine | 58-08-2 | sc-202514 sc-202514A sc-202514B sc-202514C sc-202514D | 50 g 100 g 250 g 1 kg 5 kg | $33.00 $67.00 $97.00 $192.00 $775.00 | 13 | |
Caffeine inhibits phosphodiesterases, raising intracellular cAMP levels. Elevated cAMP activates PKA, which can phosphorylate DDX35, enhancing its helicase activity. | ||||||
Rolipram | 61413-54-5 | sc-3563 sc-3563A | 5 mg 50 mg | $77.00 $216.00 | 18 | |
Rolipram, a selective phosphodiesterase-4 (PDE4) inhibitor, increases cAMP levels. This amplification activates PKA, which can phosphorylate DDX35, enhancing its activity. | ||||||
Dibutyryl-cAMP | 16980-89-5 | sc-201567 sc-201567A sc-201567B sc-201567C | 20 mg 100 mg 500 mg 10 g | $47.00 $136.00 $492.00 $4552.00 | 74 | |
Dibutyryl-cAMP is a cell-permeable cAMP analog that activates PKA. Activated PKA can phosphorylate DDX35, leading to enhanced functional activity. | ||||||
IBMX | 28822-58-4 | sc-201188 sc-201188B sc-201188A | 200 mg 500 mg 1 g | $260.00 $350.00 $500.00 | 34 | |
IBMX is a nonselective inhibitor of phosphodiesterases, raising cAMP levels. Increased cAMP activates PKA, which can phosphorylate DDX35, enhancing its functional activity. | ||||||
PGE2 | 363-24-6 | sc-201225 sc-201225C sc-201225A sc-201225B | 1 mg 5 mg 10 mg 50 mg | $57.00 $159.00 $275.00 $678.00 | 37 | |
PGE2, a prostaglandin, increases cAMP levels by activating adenylate cyclase, thereby activating PKA. Activated PKA can phosphorylate DDX35, enhancing its activity. | ||||||