DDR2 Activators
DDR2 activators encompass a variety of chemical compounds that indirectly enhance the functional activity of DDR2, a receptor tyrosine kinase involved in cell adhesion, proliferation, and extracellular matrix interactions. The primary mechanism for activating DDR2 through these compounds involves modulating the availability or functionality of its natural ligand, collagen. By influencing collagen synthesis, structure, and deposition, these activators enhance the interaction between collagen and DDR2, leading to increased receptor activity. This process is crucial for DDR2's role in signaling pathways related to cell-matrix interactions and tissue remodeling.
In addition to targeting collagen dynamics, some DDR2 activators function by affecting cellular signaling pathways and environmental factors that intersect with DDR2's role. These include various kinase inhibitors and molecules that modulate cellular processes like inflammation, fibrosis, and general signal transduction. Alterations in these pathways and processes can indirectly enhance DDR2 signaling, either through upregulation of its ligand availability or modification of the receptor's functional activity. This indirect activation approach highlights the complex regulation of receptor tyrosine kinases in cellular functions related to abnormal cell adhesion, proliferation, and extracellular matrix interactions.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Caffeine | 58-08-2 | sc-202514 sc-202514A sc-202514B sc-202514C sc-202514D | 50 g 100 g 250 g 1 kg 5 kg | $33.00 $67.00 $97.00 $192.00 $775.00 | 13 | |
Caffeine impacts several signaling pathways and could indirectly modulate DDR2 activity through changes in cellular signaling. | ||||||
Tranilast | 53902-12-8 | sc-200389 sc-200389A sc-200389B sc-200389C | 10 mg 50 mg 1 g 5 g | $31.00 $103.00 $283.00 $978.00 | 2 | |
An anti-allergic compound that also inhibits collagen synthesis, potentially altering DDR2 activation. | ||||||
Pirfenidone | 53179-13-8 | sc-203663 sc-203663A | 10 mg 50 mg | $102.00 $416.00 | 6 | |
An anti-fibrotic agent known to modulate collagen deposition, possibly affecting DDR2 activation. | ||||||
Penicillamine | 52-67-5 | sc-205795 sc-205795A | 1 g 5 g | $46.00 $96.00 | ||
Used in copper chelation; it can affect collagen cross-linking and thus may influence DDR2 activation. | ||||||
SB 431542 | 301836-41-9 | sc-204265 sc-204265A sc-204265B | 1 mg 10 mg 25 mg | $82.00 $216.00 $416.00 | 48 | |
This TGF-β receptor inhibitor can alter collagen synthesis pathways, potentially affecting DDR2 activity indirectly. | ||||||
Losartan | 114798-26-4 | sc-353662 | 100 mg | $130.00 | 18 | |
Losartan, an angiotensin II receptor antagonist, has been shown to affect collagen synthesis, which might indirectly influence DDR2 activation. | ||||||
A 419259 trihydrochloride | 1435934-25-0 | sc-361094 | 5 mg | $213.00 | 6 | |
A Src family kinase inhibitor, which, through complex signaling interactions, might indirectly activate DDR2 as part of a feedback or compensatory response. | ||||||
Halofuginone | 55837-20-2 | sc-507290 | 100 mg | $1775.00 | ||
Halofuginone inhibits collagen synthesis but can lead to compensatory cellular responses that may enhance DDR2 signaling. | ||||||
L-Ascorbic acid, free acid | 50-81-7 | sc-202686 | 100 g | $46.00 | 5 | |
Vitamin C is crucial for collagen synthesis. By promoting collagen formation, it can indirectly enhance DDR2 activation. | ||||||
Lysophosphatidic Acid | 325465-93-8 | sc-201053 sc-201053A | 5 mg 25 mg | $98.00 $341.00 | 50 | |
Lysophosphatidic acid can modulate collagen synthesis and cellular signaling, potentially impacting DDR2 activity. | ||||||