DDI1 Activators
DDI1, also known as DNA Damage Inducible Protein 1, is a gene that plays a crucial role in cellular processes related to DNA repair and protein degradation. DDI1 is found in both humans and yeast, and its functions have been extensively studied due to its significance in maintaining genomic stability and overall cellular health.One of the primary functions of DDI1 is its involvement in the ubiquitin-proteasome system (UPS), a highly regulated mechanism responsible for protein degradation within cells. DDI1 acts as an E3 ubiquitin ligase, a protein that helps tag other proteins for degradation by adding ubiquitin molecules to them. This process is essential for removing damaged or misfolded proteins and regulating the levels of various proteins in the cell.
Additionally, DDI1 is known for its role in DNA repair. It participates in the recognition and repair of DNA lesions, such as DNA double-strand breaks and interstrand crosslinks. By facilitating the degradation of proteins that inhibit DNA repair, DDI1 helps ensure efficient and accurate repair of DNA damage, which is critical for preventing mutations and maintaining genomic integrity.The study of DDI1 has broader implications in understanding diseases associated with DNA damage, such as cancer and neurodegenerative disorders. Dysregulation of DDI1 or defects in its function can lead to accumulation of damaged proteins and genetic instability, contributing to disease development.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Hydroxyurea | 127-07-1 | sc-29061 sc-29061A | 5 g 25 g | $76.00 $255.00 | 18 | |
May induce DNA damage response, potentially upregulating DDI1 as part of the cellular repair mechanism. | ||||||
Cisplatin | 15663-27-1 | sc-200896 sc-200896A | 100 mg 500 mg | $76.00 $216.00 | 101 | |
Known to cause DNA damage, which could lead to the activation of DNA repair pathways involving DDI1. | ||||||
Doxorubicin | 23214-92-8 | sc-280681 sc-280681A | 1 mg 5 mg | $173.00 $418.00 | 43 | |
As an anthracycline antibiotic, it intercalates DNA, possibly triggering a stress response that includes DDI1 expression. | ||||||
Methyl methanesulfonate | 66-27-3 | sc-250376 sc-250376A | 5 g 25 g | $55.00 $130.00 | 2 | |
A DNA alkylating agent that can cause DNA damage, potentially enhancing DDI1 expression in response. | ||||||
Etoposide (VP-16) | 33419-42-0 | sc-3512B sc-3512 sc-3512A | 10 mg 100 mg 500 mg | $32.00 $170.00 $385.00 | 63 | |
Causes DNA strand breaks, which may upregulate DDI1 as part of the DNA damage response. | ||||||
Camptothecin | 7689-03-4 | sc-200871 sc-200871A sc-200871B | 50 mg 250 mg 100 mg | $57.00 $182.00 $92.00 | 21 | |
Inhibits DNA topoisomerase I, leading to DNA damage and possible upregulation of DDI1. | ||||||
Fluorouracil | 51-21-8 | sc-29060 sc-29060A | 1 g 5 g | $36.00 $149.00 | 11 | |
Incorporated into RNA and DNA, causing damage and potentially increasing DDI1 expression. | ||||||
Bleomycin | 11056-06-7 | sc-507293 | 5 mg | $270.00 | 5 | |
Induces DNA breaks, potentially triggering a DNA damage response involving DDI1. | ||||||
Mitomycin C | 50-07-7 | sc-3514A sc-3514 sc-3514B | 2 mg 5 mg 10 mg | $65.00 $99.00 $140.00 | 85 | |
Crosslinks DNA, potentially enhancing DDI1 expression as part of the cellular response to DNA damage. | ||||||
Oxaliplatin | 61825-94-3 | sc-202270 sc-202270A | 5 mg 25 mg | $110.00 $386.00 | 8 | |
Causes DNA crosslinking, which may lead to increased DDI1 expression in response to DNA damage. | ||||||