Date published: 2025-11-24

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DAZ4 Inhibitors

DAZ4 inhibitors function primarily by targeting translational and stress-response pathways. For instance, Rapamycin acts by inhibiting mTOR, which influences S6K phosphorylation levels. Reduced S6K activity subsequently affects ribosomal recruitment and alters the functional roles played by DAZ4 in translational regulation. Similarly, Wortmannin and LY294002 act on PI3K, resulting in the inhibition of downstream molecules such as Akt. This chain of events culminates in the modulation of mTOR signaling, impacting the processes DAZ4 controls. Wortmannin, in particular, blocks PI3K at the ATP-binding site, ensuring an immediate impact on downstream processes. In addition to translational regulation, DAZ4 inhibitors like 5-Azacytidine and Actinomycin D affect the epigenetic landscape and RNA polymerase action respectively. 5-Azacytidine alters DNA methylation patterns, affecting the range of mRNAs that DAZ4 can act upon. Actinomycin D, by inhibiting RNA polymerase, disrupts the transcriptional environment, thereby affecting the same pool. Other inhibitors like SB203580 and SP600125 act on stress-response pathways. SB203580 inhibits p38 MAPK, affecting phosphorylation events that influence cellular stress responses. SP600125 inhibits JNK, thereby reducing the activity of AP-1, a transcription factor. Both these inhibitors modulate functions that fall within DAZ4's regulatory scope.

Items 1 to 10 of 12 total

Display:

Product NameCAS #Catalog #QUANTITYPriceCitationsRATING

Rapamycin

53123-88-9sc-3504
sc-3504A
sc-3504B
1 mg
5 mg
25 mg
$62.00
$155.00
$320.00
233
(4)

Inhibits mTOR, impacting S6K phosphorylation. Decreased S6K activity influences the ribosomal recruitment, which in turn affects DAZ4-regulated translational processes.

Cycloheximide

66-81-9sc-3508B
sc-3508
sc-3508A
100 mg
1 g
5 g
$40.00
$82.00
$256.00
127
(5)

Blocks translocation by binding to the 60S ribosomal subunit. Consequently, disrupts protein synthesis, restricting the functional output of DAZ4 in translational regulation.

Actinomycin D

50-76-0sc-200906
sc-200906A
sc-200906B
sc-200906C
sc-200906D
5 mg
25 mg
100 mg
1 g
10 g
$73.00
$238.00
$717.00
$2522.00
$21420.00
53
(3)

Inhibits RNA polymerase, disrupting mRNA synthesis and altering the set of mRNAs that DAZ4 can regulate post-transcriptionally.

Wortmannin

19545-26-7sc-3505
sc-3505A
sc-3505B
1 mg
5 mg
20 mg
$66.00
$219.00
$417.00
97
(3)

Blocks PI3K, which subsequently reduces Akt phosphorylation and mTOR signaling. This change in downstream signaling indirectly affects cellular functions regulated by DAZ4.

LY 294002

154447-36-6sc-201426
sc-201426A
5 mg
25 mg
$121.00
$392.00
148
(1)

Inhibits PI3K, leading to diminished phosphorylation of Akt. Alters mTOR pathway, limiting the scope of cellular processes under DAZ4's regulation.

PP242

1092351-67-1sc-301606A
sc-301606
1 mg
5 mg
$56.00
$169.00
8
(1)

Targets mTOR directly, altering the phosphorylation status of 4E-BP1 and S6K. This affects the regulatory parameters defined by DAZ4.

5-Azacytidine

320-67-2sc-221003
500 mg
$280.00
4
(1)

Induces changes in DNA methylation patterns, leading to gene expression modifications that shift the mRNA pool which DAZ4 can regulate.

SB 203580

152121-47-6sc-3533
sc-3533A
1 mg
5 mg
$88.00
$342.00
284
(5)

Inhibits p38 MAPK, thereby affecting stress-induced phosphorylation events. This results in the modulation of cellular functions that would be controlled by DAZ4.

SP600125

129-56-6sc-200635
sc-200635A
10 mg
50 mg
$40.00
$150.00
257
(3)

Targets JNK, reducing c-Jun phosphorylation and altering AP-1 transcriptional activity. These changes impose limits on mRNAs subject to DAZ4 control.

KN-93

139298-40-1sc-202199
1 mg
$178.00
25
(1)

Blocks CaMKII, affecting calcium signaling. Alters the dynamics of cellular processes that could be modulated by DAZ4.