DAZ3 Inhibitors
DAZ3 inhibitors predominantly target translational regulation and stress-response pathways to exert their effects. Among these, Rapamycin is noteworthy for its inhibition of mTOR, which leads to diminished phosphorylation of S6K. The reduction in S6K activity directly affects ribosome biogenesis, impacting the translational processes that DAZ3 seeks to control. Similarly, Wortmannin and LY294002 obstruct PI3K, thereby reducing Akt phosphorylation levels, which in turn influence mTOR signaling. This results in a constriction of the regulatory actions traditionally managed by DAZ3.
Moreover, Actinomycin D and 5-Azacytidine serve to modify the mRNA landscape within the cell. Actinomycin D, for instance, interferes with RNA polymerase, leading to a disruption in mRNA synthesis. This alters the pool of mRNAs that would otherwise be subject to post-transcriptional control by DAZ3. On the other hand, 5-Azacytidine changes the DNA methylation pattern, causing alterations in gene expression profiles. This also affects the types of mRNAs that can be subjected to DAZ3-mediated regulation, thereby setting boundaries on DAZ3's influence within the cell.
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Items 1 to 10 of 12 total
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Rapamycin | 53123-88-9 | sc-3504 sc-3504A sc-3504B | 1 mg 5 mg 25 mg | $63.00 $158.00 $326.00 | 233 | |
Inhibits mTOR, affecting S6K phosphorylation. Diminished S6K activity alters the ribosome biogenesis, affecting the translational control by DAZ3. | ||||||
Cycloheximide | 66-81-9 | sc-3508B sc-3508 sc-3508A | 100 mg 1 g 5 g | $41.00 $84.00 $275.00 | 127 | |
Binds to the 60S ribosomal subunit, blocking translocation and inhibiting protein synthesis. Thus, it restricts the translational scope of DAZ3. | ||||||
Actinomycin D | 50-76-0 | sc-200906 sc-200906A sc-200906B sc-200906C sc-200906D | 5 mg 25 mg 100 mg 1 g 10 g | $74.00 $243.00 $731.00 $2572.00 $21848.00 | 53 | |
Suppresses RNA polymerase, thus disrupting mRNA synthesis. This changes the pool of mRNAs subject to post-transcriptional control by DAZ3. | ||||||
Wortmannin | 19545-26-7 | sc-3505 sc-3505A sc-3505B | 1 mg 5 mg 20 mg | $67.00 $223.00 $425.00 | 97 | |
Inhibits PI3K, reducing Akt phosphorylation, which further influences mTOR signaling and, as a consequence, modulates the actions regulated by DAZ3. | ||||||
LY 294002 | 154447-36-6 | sc-201426 sc-201426A | 5 mg 25 mg | $123.00 $400.00 | 148 | |
Blocks PI3K, which leads to decreased levels of phosphorylated Akt, impacting the mTOR pathway and the regulatory scope of DAZ3. | ||||||
PP242 | 1092351-67-1 | sc-301606A sc-301606 | 1 mg 5 mg | $57.00 $172.00 | 8 | |
Directly inhibits mTOR, leading to altered phosphorylation levels of 4E-BP1 and S6K, which impacts the processes controlled by DAZ3. | ||||||
5-Azacytidine | 320-67-2 | sc-221003 | 500 mg | $280.00 | 4 | |
Alters DNA methylation patterns, inducing changes in gene expression and modifying the set of mRNAs that DAZ3 can regulate. | ||||||
SB 203580 | 152121-47-6 | sc-3533 sc-3533A | 1 mg 5 mg | $90.00 $349.00 | 284 | |
Blocks p38 MAPK, thereby affecting stress-induced phosphorylation of Hsp27, which indirectly modulates functions that would be regulated by DAZ3. | ||||||
SP600125 | 129-56-6 | sc-200635 sc-200635A | 10 mg 50 mg | $40.00 $150.00 | 257 | |
Inhibits JNK, thereby reducing c-Jun phosphorylation, leading to changes in AP-1 transcriptional activity, which impacts mRNAs that DAZ3 would regulate. | ||||||
KN-93 | 139298-40-1 | sc-202199 | 1 mg | $182.00 | 25 | |
Inhibits CaMKII, thereby affecting calcium signaling that indirectly modulates cellular processes that DAZ3 regulates. | ||||||