DAT Inhibitors
Items 1 to 10 of 16 total
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Benztropine mesylate | 132-17-2 | sc-202495 sc-202495A | 1 g 5 g | $45.00 $157.00 | 3 | |
An inhibitor of DAT, a protein involved in neurotransmitter transport. By targeting SLC6A3, it modulates neurotransmitter reuptake processes without delving into clinical or therapeutic contexts. | ||||||
Bupropion HCl | 31677-93-7 | sc-201121 sc-201121A | 50 mg 250 mg | $79.00 $298.00 | 4 | |
Bupropion HCl is an inhibitor of dopamine and SLC6A2 | ||||||
GBR 12935 dihydrochloride | 67469-81-2 | sc-203965 sc-203965A | 10 mg 50 mg | $70.00 $275.00 | 1 | |
GBR 12935 dihydrochloride acts as a potent dopamine transporter (DAT) inhibitor, exhibiting high affinity for the transporter through specific electrostatic and hydrophobic interactions. Its unique structural conformation enhances binding stability, influencing the kinetics of dopamine reuptake. The compound's ability to modulate DAT activity reveals insights into neurotransmitter dynamics, while its distinct solubility characteristics affect its interaction with lipid membranes, impacting cellular uptake and distribution. | ||||||
Indatraline hydrochloride | 96850-13-4 | sc-203605 sc-203605A | 10 mg 50 mg | $151.00 $575.00 | ||
Indatraline hydrochloride functions as a selective dopamine transporter (DAT) inhibitor, characterized by its unique ability to form strong hydrogen bonds with key amino acid residues within the transporter. This interaction alters the conformational dynamics of DAT, leading to a significant reduction in dopamine reuptake efficiency. Additionally, its distinct lipophilicity influences membrane permeability, affecting its distribution and interaction with cellular environments, thereby modulating neurotransmitter signaling pathways. | ||||||
Clomipramine hydrochloride | 17321-77-6 | sc-203898 | 1 g | $38.00 | 2 | |
Clomipramine hydrochloride acts as a potent dopamine transporter (DAT) modulator, exhibiting unique electrostatic interactions with the transporter’s binding site. This compound's structural conformation allows for enhanced affinity, effectively stabilizing the DAT in an inactive state. Its hydrophobic regions facilitate integration into lipid bilayers, influencing the kinetics of dopamine transport. Furthermore, the compound's stereochemistry plays a crucial role in its binding efficacy, impacting overall transporter functionality. | ||||||
N,O-Bis(trimethylsilyl)trifluoroacetamide | 25561-30-2 | sc-364755 sc-364755A sc-364755B | 5 g 50 g 100 g | $34.00 $240.00 $416.00 | ||
N,O-Bis(trimethylsilyl)trifluoroacetamide serves as a versatile derivatizing agent, enhancing the volatility and stability of polar compounds. Its trifluoroacetamide moiety engages in strong hydrogen bonding, facilitating the formation of stable derivatives. The trimethylsilyl groups contribute to increased lipophilicity, promoting efficient gas chromatography separation. Additionally, the compound's unique steric properties influence reaction kinetics, allowing for rapid derivatization under mild conditions. | ||||||
GBR-12909 | 67469-78-7 | sc-200398 sc-200398A | 5 mg 25 mg | $64.00 $188.00 | 4 | |
GBR-12909 is a selective dopamine transporter (DAT) inhibitor that exhibits unique binding characteristics, engaging in specific interactions with the DAT protein. Its structure allows for a high affinity and selectivity, influencing the kinetics of dopamine reuptake inhibition. The compound's distinct conformational flexibility enables it to modulate the transporter's activity, potentially altering the dynamics of neurotransmitter cycling. This behavior highlights its role in influencing synaptic dopamine levels. | ||||||
Tomoxetine hydrochloride | 82248-59-7 | sc-204349 sc-204349A | 10 mg 50 mg | $161.00 $686.00 | ||
Tomoxetine hydrochloride acts as a selective dopamine transporter (DAT) modulator, characterized by its unique ability to form stable interactions with the DAT protein. Its structural features facilitate a distinct binding affinity, impacting the kinetics of dopamine transport. The compound's specific conformational adaptability allows it to influence the transporter's conformational states, thereby affecting the overall dynamics of dopamine availability and signaling pathways. | ||||||
SKF 83566 hydrobromide | 108179-91-5 | sc-361360 sc-361360A | 10 mg 50 mg | $132.00 $400.00 | ||
a compound that selectively blocks the dopamine D1-like receptor family, particularly the D1 receptor. It doesn't directly inhibit DAT (dopamine transporter), responsible for dopamine reuptake. Unlike DAT inhibitors like cocaine, SKF 83566 hydrobromide doesn't raise dopamine levels by blocking reuptake. Its main action is altering dopamine receptors, not directly affecting the transporter. | ||||||
BTCP maleate | 112726-66-6 | sc-200397 sc-200397A | 10 mg 50 mg | $125.00 $560.00 | ||
BTCP maleate functions as a potent dopamine transporter (DAT) modulator, exhibiting unique molecular interactions that enhance its binding specificity. Its structural conformation promotes selective engagement with the DAT, altering the transport kinetics of dopamine. This compound's ability to stabilize certain conformational states of the transporter leads to significant modulation of dopamine reuptake processes, influencing neurotransmitter dynamics and synaptic activity. | ||||||