Molecular structure of GBR 12935 dihydrochloride, CAS Number: 67469-81-2
GBR 12935 dihydrochloride (CAS 67469-81-2)
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Alternate Names:
1-(2-Diphenylmethoxyethyl)-4-(3-phenylpropyl)piperazine dihydrochloride
Application:
GBR 12935 dihydrochloride is a DAT and SLC6A2 inhibitor
CAS Number:
67469-81-2
Molecular Weight:
487.51
Molecular Formula:
C28H34N2O•2HCl
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
GBR 12935 dihydrochloride inhibits DAT (dopamine transporter) (Ki = 21.5 nM) and SLC6A2 (norepinephrine transporter) (Ki = 225 nM). GBR 12935 does not inhibit the serotonin transporter (Ki = 6.5 μM). GBR 12935 binds to a nondopaminergic piperazine site in blood platelets and brain that has been identified as cytochrome P450.
GBR 12935 dihydrochloride (CAS 67469-81-2) References
Andersen et al (1987) Biochemical and pharmacological characterization of [3H]GBR 12935 binding in vitro to rat striatal membranes: labelling of the dopamine uptake complex. J.Neurochem. 48 1887. Reith et al (1992) Evidence for mutually exclusive binding of cocaine, BTCP, GBR 12935, and dopamine to the dopamine transporter. Eur.J.Pharmacol.Mol.Pharmacol.Sect. 227 417. Reith et al (1994) GBR 12909 and 12935 block dopamine uptake into brain synaptic vesicles as well as nerve endings. Eur.J.Pharmacol. 253 175.Inhibitor of:
DAT, SLC6A (solute carrier family 6), and SLC6A2.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
GBR 12935 dihydrochloride, 10 mg | sc-203965 | 10 mg | $70.00 | |||
GBR 12935 dihydrochloride, 50 mg | sc-203965A | 50 mg | $275.00 |