Bupropion HCl CAS: 31677-93-7
MF: C13H18ClNO•HCl
MW: 276.2
An inhibitor of dopamine and SLC6A2.

Bupropion HCl (CAS 31677-93-7)

Bupropion HCl | CAS 31677-93-7 is rated 5.0 out of 5 by 1.
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Alternate Names: 1-(3-chlorophenyl)-2-[(1,1-dimethylethyl)amino]-1-propane, monohydrochloride
Application: Bupropion HCl is an inhibitor of dopamine and SLC6A2
CAS Number: 31677-93-7
Purity: ≥99%
Molecular Weight: 276.2
Molecular Formula: C13H18ClNO•HCl
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data (including water content).

Bupropion HCl is a non-selective inhibitor of dopamine and SLC6A2 (Ki values are 1.4 μM for SLC6A2, 2.8 μM for dopamine, and 45 μM for serotonin). Bupropion also inhibits neuronal nicotinic acetylcholine receptors. Bupropion HCl is an inhibitor of AChR, DAT and ST.


References

1. Cooper, B.R., et al. 1980. J. Pharmacol. Exp. Ther. 215: 127-134. PMID: 6778989
2. Lerman, C., et al. 2005. J. Clin. Oncol. 23: 311-323. PMID: 15637394
3. Silverstone, P.H., et al. 2008. Ann Gen Psychiatry. 7: 11. PMID: 18706108
4. Papakostas, G.I., et al. 2008. J Clin Psychiatry. 69: 1287-1292. PMID: 18605812
5. Henshall, D.C., et al. 2009. Neuropsychiatr Dis Treat. 5: 189-206. PMID: 19557114

Appearance :
Powder
Physical State :
Solid
Solubility :
Soluble in water (>25 mg/ml), ethanol 193mg/ml, 0.1 N HCl 333 mg/ml
Storage :
Store at 4° C
Melting Point :
236-238° C
Ki Data :
serotonin transporter : Ki= 45 µM; dopamine transporter: Ki= 2.8 µM; norepinephrine transporters: Ki= 1.4 µM
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
WGK Germany :
3
RTECS :
UG8858000
PubChem CID :
62884
Merck Index :
14: 1499
MDL Number :
MFCD00055209
EC Number :
250-759-9
SMILES :
CC(C(=O)C1=CC(=CC=C1)Cl)NC(C)(C)C.Cl

Download SDS (MSDS)

Certificate of Analysis

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Bupropion HCl (CAS 31677-93-7)  Product Citations

See how others have used Bupropion HCl (CAS 31677-93-7). Click on the entry to view the PubMed entry .

Citations 1 to 3 of 3 total

PMID: # 25616031  Hall, BJ. et al. 2015. Pharmacology, biochemistry, and behavior. 130: 84-9.

PMID: # 25249693  Wu, J. et al. 2014. Drug Metab. Dispos. 42: 2058-67.

PMID: # 23751335  Writer, JH. et al. 2013. Sci. Total Environ. 461-462: 519-27.

Citations 1 to 3 of 3 total

Hola, ¿pueden hacer envíos a Guadalajara Jalisco, México? necesito información para una investigación de la Universidad de Guadalajara

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Answered by: Tech Service 3
Date published: 2017-04-24

What is the appearance of the compound?

Asked by: two2igm05
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Answered by: Tech Service 8
Date published: 2017-01-20
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Rated 5 out of 5 by from Henshall et al Henshall et al. (PubMed ID 19557114) found that the dopamine inhibitor, Bupropion HCl, induced a higher increase in cortical EEG seizures in mice compared to bupropion HBr. -SCBT Publication Review
Date published: 2015-05-10
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