Date published: 2026-5-5

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Indatraline hydrochloride (CAS 96850-13-4)

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Alternate Names:
(±)-trans-3-(3,4-Dichlorophenyl)-N-methyl-1-indanamine hydrochloride; Lu 19-005
Application:
Indatraline hydrochloride is an inhibitor of ST, DAT, and SLC6A2
CAS Number:
96850-13-4
Molecular Weight:
328.67
Molecular Formula:
C16H15Cl2N•HCl
Supplemental Information:
This is classified as a Dangerous Good for transport and may be subject to additional shipping charges.
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.

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Indatraline hydrochloride (IH) is renowned for its potent and selective inhibition of serotonin reuptake (SSRI). This inhibition results in an increased availability of serotonin for neurons, ultimately heightening the activity of serotonin-dependent pathways. In vitro studies have been conducted to investigate the effects of Indatraline hydrochloride. As a synthetic compound, Indatraline hydrochloride bears a structural resemblance to other SSRIs like fluvoxamine and citalopram.


Indatraline hydrochloride (CAS 96850-13-4) References

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  2. The identification of inhibitors of Schistosoma mansoni miracidial transformation by incorporating a medium-throughput small-molecule screen.  |  Taft, AS., et al. 2010. Exp Parasitol. 125: 84-94. PMID: 20060828
  3. Recombinant human immunodeficiency virus-1 transactivator of transcription1-86 allosterically modulates dopamine transporter activity.  |  Zhu, J., et al. 2011. Synapse. 65: 1251-4. PMID: 21538554
  4. Development and validation of an LC-ESI-MS/MS method for the triple reuptake inhibitor indatraline enabling its quantification in MS Binding Assays.  |  Grimm, SH., et al. 2015. Anal Bioanal Chem. 407: 471-85. PMID: 25450050
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  6. Prospects of Pharmacological Interventions to Organismal Aging.  |  Hillson, O., et al. 2018. Biomol Concepts. 9: 200-215. PMID: 30676997
  7. Chemical Screening Approaches Enabling Drug Discovery of Autophagy Modulators for Biomedical Applications in Human Diseases.  |  Panda, PK., et al. 2019. Front Cell Dev Biol. 7: 38. PMID: 30949479
  8. Anti-α-synuclein ASO delivered to monoamine neurons prevents α-synuclein accumulation in a Parkinson's disease-like mouse model and in monkeys.  |  Alarcón-Arís, D., et al. 2020. EBioMedicine. 59: 102944. PMID: 32810825
  9. Intracerebral Administration of a Ligand-ASO Conjugate Selectively Reduces α-Synuclein Accumulation in Monoamine Neurons of Double Mutant Human A30P*A53T*α-Synuclein Transgenic Mice.  |  Pavia-Collado, R., et al. 2021. Int J Mol Sci. 22: PMID: 33805843
  10. Up and Down γ-Synuclein Transcription in Dopamine Neurons Translates into Changes in Dopamine Neurotransmission and Behavioral Performance in Mice.  |  Pavia-Collado, R., et al. 2022. Int J Mol Sci. 23: PMID: 35163729
  11. Analgesic Effects of Vilazodone, Indatraline, and Talsupram in a Rat Model of Neuropathic Pain.  |  Hacısüleyman, L., et al. 2022. Turk J Pharm Sci. 19: 336-342. PMID: 35775407
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  13. Components of the sympathetic nervous system as targets to modulate inflammation - rheumatoid arthritis synovial fibroblasts as neuron-like cells?  |  Cheng, X., et al. 2023. J Inflamm (Lond). 20: 9. PMID: 36918850

Ordering Information

Product NameCatalog #UNITPriceQtyFAVORITES

Indatraline hydrochloride, 10 mg

sc-203605
10 mg
$151.00

Indatraline hydrochloride, 50 mg

sc-203605A
50 mg
$575.00