Molecular structure of Tomoxetine hydrochloride, CAS Number: 82248-59-7
Tomoxetine hydrochloride (CAS 82248-59-7)
Alternate Names:
Atomoxetine hydrochloride
Application:
Tomoxetine hydrochloride is a selective SLC6A2 inhibitor
CAS Number:
82248-59-7
Purity:
≥99%
Molecular Weight:
291.82
Molecular Formula:
C17H21NO•HCl
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
Tomoxetine hydrochloride (Atomoxetine, LY 139603) is a competitive and specific inhibitor of SLC6A2 while demonstrating weak ST and DAT inhibition as studied in synaptosomes of rat hypothalamus. Additionally, studies indicate that this (−) optical isomer is more effective than the (+) isomer, LY139602 (ent S-(+)-Atomoxetine Hydrochloride; sc-211408). In the prefrontal cortex of rats, Tomoxetine was reported to not cause an increase in dopamine within the striatum or nucleus accumbens which may be useful in additional research studies investigating the reward pathways of the brain. Tomoxetine hydrochloride is an inhibitor of NMDA.
Tomoxetine hydrochloride (CAS 82248-59-7) References
- Disposition and metabolic fate of atomoxetine hydrochloride: pharmacokinetics, metabolism, and excretion in the Fischer 344 rat and beagle dog. | Mattiuz, EL., et al. 2003. Drug Metab Dispos. 31: 88-97. PMID: 12485957
- Atomoxetine reduces anticipatory responding in a 5-choice serial reaction time task for adult zebrafish. | Parker, MO., et al. 2014. Psychopharmacology (Berl). 231: 2671-9. PMID: 24481568
- [Treatment of Tourette syndrome by tomoxetine hydrochloride in older children]. | Liu, MX., et al. 2014. Zhongguo Dang Dai Er Ke Za Zhi. 16: 1162-4. PMID: 25406564
- Abnormal Resting-State Functional Connectivity of Insular Subregions and Disrupted Correlation with Working Memory in Adults with Attention Deficit/Hyperactivity Disorder. | Zhao, Q., et al. 2017. Front Psychiatry. 8: 200. PMID: 29075206
- Shared and distinct resting functional connectivity in children and adults with attention-deficit/hyperactivity disorder. | Guo, X., et al. 2020. Transl Psychiatry. 10: 65. PMID: 32066697
- Effect of non-pharmacological treatment on the full recovery of social functioning in patients with attention deficit hyperactivity disorder. | Lv, YB., et al. 2023. World J Clin Cases. 11: 3238-3247. PMID: 37274030
- Antagonism by tomoxetine of the depletion of norepinephrine and epinephrine in rat brain by alpha-methyl-m-tyrosine. | Fuller, RW. and Hemrick-Luecke, SK. 1983. Res Commun Chem Pathol Pharmacol. 41: 169-72. PMID: 6604933
- Prozac (fluoxetine, Lilly 110140), the first selective serotonin uptake inhibitor and an antidepressant drug: twenty years since its first publication. | Wong, DT., et al. 1995. Life Sci. 57: 411-41. PMID: 7623609
- Fluoxetine selectively alters 5-hydroxytryptamine1A and gamma-aminobutyric acidB receptor-mediated hyperpolarization in area CA1, but not area CA3, hippocampal pyramidal cells. | Beck, SG., et al. 1997. J Pharmacol Exp Ther. 281: 115-22. PMID: 9103487
- Neurotransmitter receptor and transporter binding profile of antidepressants and their metabolites. | Owens, MJ., et al. 1997. J Pharmacol Exp Ther. 283: 1305-22. PMID: 9400006
Inhibitor of:
DAT, NMDA, SLC6A2, and ST.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Tomoxetine hydrochloride, 10 mg | sc-204349 | 10 mg | $161.00 | |||
Tomoxetine hydrochloride, 50 mg | sc-204349A | 50 mg | $686.00 |