Date published: 2025-12-18

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DAF-16 Inhibitors

DAF-16 inhibitors constitute a distinct chemical class of compounds that target the transcription factor DAF-16 (Abnormal Dauer Formation 16) in the nematode worm Caenorhabditis elegans. DAF-16 is a crucial regulator of lifespan and stress responses in these organisms, and inhibiting its activity has been extensively studied to gain insights into the molecular pathways governing aging and stress resistance. These inhibitors are designed to interact with DAF-16 at a molecular level, aiming to modulate its function or localization within the cell. By carefully disrupting DAF-16 activity, researchers aim to unravel its role in various biological processes. The inhibitors can have diverse chemical structures and mechanisms of action, affecting different upstream or downstream signaling pathways associated with DAF-16 regulation. Investigating DAF-16 inhibitors provides valuable tools to better comprehend the genetic and molecular underpinnings of aging and stress responses in model organisms, contributing to the broader understanding of biological systems and their complexities.
Product NameCAS #Catalog #QUANTITYPriceCitationsRATING

Wortmannin

19545-26-7sc-3505
sc-3505A
sc-3505B
1 mg
5 mg
20 mg
$66.00
$219.00
$417.00
97
(3)

A naturally occurring fungal metabolite, wortmannin has shown to inhibit DAF-16 function through its effects on the phosphatidylinositol 3-kinase (PI3K) pathway.

LY 294002

154447-36-6sc-201426
sc-201426A
5 mg
25 mg
$121.00
$392.00
148
(1)

Another PI3K inhibitor that has been reported to modulate DAF-16 activity and its downstream signaling pathways.

SB-216763

280744-09-4sc-200646
sc-200646A
1 mg
5 mg
$70.00
$198.00
18
(1)

A specific inhibitor of glycogen synthase kinase-3 (GSK-3) that has shown to influence DAF-16 function in certain studies.

KU 0063794

938440-64-3sc-361219
10 mg
$209.00
(1)

This compound is an mTOR (mammalian target of rapamycin) inhibitor that has been reported to regulate DAF-16 localization and activity.

BML-275

866405-64-3sc-200689
sc-200689A
5 mg
25 mg
$94.00
$348.00
69
(1)

A specific AMP-activated protein kinase (AMPK) inhibitor that has shown to modulate DAF-16 activity and its downstream effects on metabolism.

Triciribine

35943-35-2sc-200661
sc-200661A
1 mg
5 mg
$102.00
$138.00
14
(1)

An Akt inhibitor that has been investigated for its potential to affect DAF-16 signaling and longevity in certain experimental models.

Resveratrol

501-36-0sc-200808
sc-200808A
sc-200808B
100 mg
500 mg
5 g
$60.00
$185.00
$365.00
64
(2)

A natural polyphenol found in various plants, resveratrol has shown to influence DAF-16 activity and stress resistance in some studies.

5-Iodotubercidin

24386-93-4sc-3531
sc-3531A
1 mg
5 mg
$150.00
$455.00
20
(2)

An adenosine kinase inhibitor that has been reported to affect DAF-16 localization and function.

LY2090314

603288-22-8sc-507359
5 mg
$175.00
(0)

A specific inhibitor of protein kinase CK2, which has been implicated in DAF-16 regulation.