D630037F22Rik Inhibitors
The TBC1D32 Inhibitors represent a pharmacologically diverse array of compounds designed to modulate the function of TBC1D32, a protein intricately involved in various cellular processes, including animal organ development, non-motile cilium assembly, and the smoothened signaling pathway crucial for dorsal/ventral neural tube patterning. TBC1D32, orthologous to human TBC1D32, is predicted to be located in the cilium and cytoplasm and plays a vital role in cellular functions related to development and signaling cascades. Brefeldin A, a fungal metabolite, directly inhibits TBC1D32 by disrupting vesicular transport processes and the functioning of the Golgi apparatus. This disruption leads to impaired smoothened signaling and cilium assembly involved in dorsal/ventral neural tube patterning. Leptomycin B, an antifungal antibiotic, indirectly inhibits TBC1D32 by blocking nuclear export through CRM1, influencing cytoplasmic localization, and consequently disrupting processes such as animal organ development, non-motile cilium assembly, and smoothened signaling.
Wortmannin, a fungal metabolite, directly inhibits TBC1D32 by targeting PI3-kinase, affecting intracellular signaling pathways and disrupting smoothened signaling and cilium assembly essential for dorsal/ventral neural tube patterning and animal organ development. Dynasore, a dynamin inhibitor, indirectly inhibits TBC1D32 by blocking endocytosis, influencing cytoplasmic processes, and disrupting non-motile cilium assembly and smoothened signaling involved in dorsal/ventral neural tube patterning and animal organ development. AG-490, a JAK2 inhibitor, indirectly inhibits TBC1D32 by affecting the JAK-STAT pathway, disrupting signaling cascades, and consequently impairing smoothened signaling and non-motile cilium assembly involved in dorsal/ventral neural tube patterning and animal organ development. Collectively, these inhibitors offer a comprehensive toolkit for researchers investigating the multifaceted roles of TBC1D32 in cellular development and signaling processes. Understanding how these chemicals modulate TBC1D32 function sheds light on strategies for conditions associated with aberrant cellular processes governed by this protein.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Brefeldin A | 20350-15-6 | sc-200861C sc-200861 sc-200861A sc-200861B | 1 mg 5 mg 25 mg 100 mg | $31.00 $53.00 $124.00 $374.00 | 25 | |
Brefeldin A, a fungal metabolite, directly inhibits TBC1D32 by disrupting vesicular transport processes and the functioning of the Golgi apparatus, leading to impaired smoothened signaling and cilium assembly involved in dorsal/ventral neural tube patterning. | ||||||
Leptomycin B | 87081-35-4 | sc-358688 sc-358688A sc-358688B | 50 µg 500 µg 2.5 mg | $107.00 $416.00 $1248.00 | 35 | |
Leptomycin B, an antifungal antibiotic, indirectly inhibits TBC1D32 by blocking nuclear export through CRM1, influencing cytoplasmic localization, and consequently disrupting processes such as animal organ development, non-motile cilium assembly, and smoothened signaling. | ||||||
Wortmannin | 19545-26-7 | sc-3505 sc-3505A sc-3505B | 1 mg 5 mg 20 mg | $67.00 $223.00 $425.00 | 97 | |
Wortmannin, a fungal metabolite, directly inhibits TBC1D32 by targeting PI3-kinase, affecting intracellular signaling pathways and disrupting smoothened signaling and cilium assembly essential for dorsal/ventral neural tube patterning and animal organ development. | ||||||
Dynamin Inhibitor I, Dynasore | 304448-55-3 | sc-202592 | 10 mg | $89.00 | 44 | |
Dynasore, a dynamin inhibitor, indirectly inhibits TBC1D32 by blocking endocytosis, influencing cytoplasmic processes, and disrupting non-motile cilium assembly and smoothened signaling involved in dorsal/ventral neural tube patterning and animal organ development. | ||||||
Y-27632, free base | 146986-50-7 | sc-3536 sc-3536A | 5 mg 50 mg | $186.00 $707.00 | 88 | |
Y-27632, a Rho kinase inhibitor, directly inhibits TBC1D32 by modulating actin cytoskeleton dynamics, affecting cellular processes such as non-motile cilium assembly and smoothened signaling crucial for dorsal/ventral neural tube patterning and animal organ development. | ||||||
PI-103 | 371935-74-9 | sc-203193 sc-203193A | 1 mg 5 mg | $33.00 $131.00 | 3 | |
PI-103, a dual PI3-kinase/mTOR inhibitor, directly inhibits TBC1D32 by interfering with intracellular signaling pathways, disrupting smoothened signaling, and impacting cilium assembly essential for dorsal/ventral neural tube patterning and animal organ development. | ||||||
ML-7 hydrochloride | 110448-33-4 | sc-200557 sc-200557A | 10 mg 50 mg | $91.00 $267.00 | 13 | |
ML-7 hydrochloride, a myosin light chain kinase inhibitor, directly inhibits TBC1D32 by modulating actin dynamics, affecting non-motile cilium assembly, and disrupting smoothened signaling involved in dorsal/ventral neural tube patterning and animal organ development. | ||||||
SB 203580 | 152121-47-6 | sc-3533 sc-3533A | 1 mg 5 mg | $90.00 $349.00 | 284 | |
SB-203580, a p38 MAPK inhibitor, indirectly inhibits TBC1D32 by affecting the MAPK pathway, disrupting signaling cascades, and consequently impairing smoothened signaling and cilium assembly crucial for dorsal/ventral neural tube patterning and animal organ development. | ||||||
Latrunculin A, Latrunculia magnifica | 76343-93-6 | sc-202691 sc-202691B | 100 µg 500 µg | $265.00 $815.00 | 36 | |
Latrunculin A, an actin polymerization inhibitor, directly inhibits TBC1D32 by disrupting actin dynamics, influencing non-motile cilium assembly, and impairing smoothened signaling involved in dorsal/ventral neural tube patterning and animal organ development. | ||||||
GSK-3 Inhibitor XVI | 252917-06-9 | sc-221691 sc-221691A | 5 mg 25 mg | $180.00 $610.00 | 4 | |
CHIR-99021, GSK-3 Inhibitor XVI, directly inhibits TBC1D32 by affecting the Wnt signaling pathway, disrupting smoothened signaling, and impairing non-motile cilium assembly crucial for dorsal/ventral neural tube patterning and animal organ development. | ||||||