D54 Activators
D54 Activators can be categorized into two main types: those that increase cAMP levels and those that inhibit cAMP breakdown. The first category includes forskolin, isoproterenol, 8-Bromo-cAMP, PGE2, epinephrine, dobutamine, N6,2'-O-Dibutyryladenosine 3',5'-cyclic monophosphate, terbutaline, and salbutamol. These compounds stimulate adenylate cyclase or are cell-permeable cAMP analogs that increase the levels of cAMP in the cell. The elevated cAMP levels can activate protein kinase A (PKA), a known phosphorylator of D54. Phosphorylation by PKA can enhance the functional activity of D54, making these compounds effective D54 activators.
The second category includes rolipram and IBMX, which are phosphodiesterase inhibitors that prevent the breakdown of cAMP, leading to increased cAMP levels. Elevated cAMP levels can activate PKA, which can phosphorylate and activate D54. The unique action of H-89 dihydrochloride, an inhibitor of PKA, also indirectly enhances the activity of D54,which is known to be negatively regulated by PKA-mediated phosphorylation. Inhibition of PKA releases this negative regulation, leading to increased D54 activity.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $76.00 $150.00 $725.00 $1385.00 $2050.00 | 73 | |
Forskolin is a potent activator of adenylate cyclase, which can increase the levels of cAMP. Elevated cAMP levels can activate protein kinase A (PKA). PKA is known to phosphorylate proteins like D54 and increase their activity. | ||||||
Isoproterenol Hydrochloride | 51-30-9 | sc-202188 sc-202188A | 100 mg 500 mg | $27.00 $37.00 | 5 | |
Isoproterenol is a non-selective beta-adrenergic agonist, which can stimulate adenylate cyclase and increase cAMP levels. The enhanced cAMP levels can activate PKA, which can phosphorylate proteins like D54 and enhance their activity. | ||||||
Rolipram | 61413-54-5 | sc-3563 sc-3563A | 5 mg 50 mg | $75.00 $212.00 | 18 | |
Rolipram inhibits phosphodiesterase 4, preventing the breakdown of cAMP, leading to increased cAMP levels. This can activate PKA, which can phosphorylate D54 and increase its activity. | ||||||
8-Bromo-cAMP | 76939-46-3 | sc-201564 sc-201564A | 10 mg 50 mg | $97.00 $224.00 | 30 | |
8-Bromo-cAMP is a cell-permeable cAMP analog that can activate PKA. Activated PKA can phosphorylate D54 and enhance its activity. | ||||||
IBMX | 28822-58-4 | sc-201188 sc-201188B sc-201188A | 200 mg 500 mg 1 g | $159.00 $315.00 $598.00 | 34 | |
IBMX is a non-selective phosphodiesterase inhibitor that increases intracellular cAMP levels. Elevated cAMP can activate PKA, which can phosphorylate D54 and enhance its activity. | ||||||
PGE2 | 363-24-6 | sc-201225 sc-201225C sc-201225A sc-201225B | 1 mg 5 mg 10 mg 50 mg | $56.00 $156.00 $270.00 $665.00 | 37 | |
PGE2 is a prostaglandin that can increase cAMP levels, leading to PKA activation. Activated PKA can phosphorylate D54 and enhance its activity. | ||||||
(−)-Epinephrine | 51-43-4 | sc-205674 sc-205674A sc-205674B sc-205674C sc-205674D | 1 g 5 g 10 g 100 g 1 kg | $40.00 $102.00 $197.00 $1739.00 $16325.00 | ||
Epinephrine is a non-selective adrenergic agonist that can stimulate adenylate cyclase activity and increase cAMP levels. The elevated cAMP levels can activate PKA, which can phosphorylate D54 and enhance its activity. | ||||||
Dobutamine | 34368-04-2 | sc-507555 | 100 mg | $295.00 | ||
Dobutamine is a beta-1 adrenergic receptor agonist that can stimulate adenylate cyclase and enhance cAMP production. Increased cAMP can activate PKA, which can phosphorylate D54 and increase its activity. | ||||||
Dibutyryl-cAMP | 16980-89-5 | sc-201567 sc-201567A sc-201567B sc-201567C | 20 mg 100 mg 500 mg 10 g | $45.00 $130.00 $480.00 $4450.00 | 74 | |
N6,2'-O-Dibutyryladenosine 3',5'-cyclic monophosphate is a cell-permeable cAMP analog that can activate PKA. Activated PKA can phosphorylate D54, resulting in enhanced activity. | ||||||
Terbutaline Hemisulfate | 23031-32-5 | sc-204911 sc-204911A | 1 g 5 g | $90.00 $371.00 | 2 | |
Terbutaline is a beta-2 adrenergic receptor agonist that can stimulate adenylate cyclase and increase cAMP levels. Elevated levels of cAMP can activate PKA, which can phosphorylate D54, resulting in enhanced activity. | ||||||