D2HGDH Activators
D2HGDH activators are a class of molecules that interact with the enzyme D-2-hydroxyglutarate dehydrogenase to enhance its activity. These molecules can include substrates, cofactors, and various small molecules that improve enzyme kinetics by increasing substrate availability, stabilizing the enzyme structure, or augmenting the presence of essential cofactors. The activators might interact with the enzyme directly, bind to regulatory sites, or participate in parallel metabolic pathways that ultimately lead to increased enzyme activity.
The efficacy of these activators is contingent upon their interaction with the enzyme or the metabolic environment within the cell. Enzyme activators can increase the conversion rate of D-2-hydroxyglutarate to alpha-ketoglutarate, thereby playing a pivotal role in metabolic regulation. Since D2HGDH is part of a larger metabolic network, the activity of this enzyme is also influenced by the availability of metabolites and coenzymes in this network. Thus, the impact of activators can be mediated through their influence on the concentrations of these compounds within the cell, leading to a higher enzymatic activity of D2HGDH.
SEE ALSO...
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
α-Ketoglutaric Acid | 328-50-7 | sc-208504 sc-208504A sc-208504B sc-208504C sc-208504D sc-208504E sc-208504F | 25 g 100 g 250 g 500 g 1 kg 5 kg 16 kg | $33.00 $43.00 $63.00 $110.00 $188.00 $738.00 $2091.00 | 2 | |
A key compound in the Krebs cycle that D2HGDH converts D-2-hydroxyglutarate into; its availability can promote D2HGDH activity. | ||||||
NAD+, Free Acid | 53-84-9 | sc-208084B sc-208084 sc-208084A sc-208084C sc-208084D sc-208084E sc-208084F | 1 g 5 g 10 g 25 g 100 g 1 kg 5 kg | $57.00 $191.00 $302.00 $450.00 $1800.00 $3570.00 $10710.00 | 4 | |
A coenzyme required by D2HGDH for the oxidation of D-2-hydroxyglutarate; increasing its concentration can enhance D2HGDH activity. | ||||||
Riboflavin | 83-88-5 | sc-205906 sc-205906A sc-205906B | 25 g 100 g 1 kg | $41.00 $112.00 $525.00 | 3 | |
Precursor of FAD, can indirectly enhance the activity of FAD-dependent enzymes like D2HGDH. | ||||||
Vitamin B1 | 59-43-8 | sc-338735 | 5 g | $611.00 | ||
As a coenzyme in the form of thiamine pyrophosphate, it plays a role in the decarboxylation of alpha-keto acids and could affect D2HGDH activity. | ||||||
α-Lipoic Acid | 1077-28-7 | sc-202032 sc-202032A sc-202032B sc-202032C sc-202032D | 5 g 10 g 250 g 500 g 1 kg | $69.00 $122.00 $212.00 $380.00 $716.00 | 3 | |
Involved in the mitochondrial metabolism and could influence the activity of D2HGDH as part of the mitochondrial matrix environment. | ||||||
Coenzyme Q10 | 303-98-0 | sc-205262 sc-205262A | 1 g 5 g | $71.00 $184.00 | 1 | |
As part of the mitochondrial electron transport chain, its presence can affect mitochondrial function and indirectly D2HGDH activity. | ||||||
Calcium | 7440-70-2 | sc-252536 | 5 g | $209.00 | ||
Similar to magnesium, it can play a role in enzyme stability and function. | ||||||
D-(+)-Biotin | 58-85-5 | sc-204706 sc-204706A sc-204706B | 1 g 5 g 25 g | $41.00 $107.00 $333.00 | 1 | |
As a coenzyme, it is involved in carboxylation reactions, which could have an indirect effect on D2HGDH activity. | ||||||
Pyridoxal-5-phosphate | 54-47-7 | sc-205825 | 5 g | $104.00 | ||
The active form of vitamin B6, involved in amino acid metabolism, might affect D2HGDH activity indirectly through metabolic interactions. | ||||||
Zinc | 7440-66-6 | sc-213177 | 100 g | $48.00 | ||
A metal ion that can act as a cofactor for various enzymes, could potentially stabilize D2HGDH structure and enhance its activity. | ||||||