D2Bwg1335e Inhibitors
Chemical inhibitors of D2Bwg1335e can affect its function through the modulation of various signaling pathways with which it is associated. LY294002 and Wortmannin are both inhibitors of phosphoinositide 3-kinases (PI3K), crucial components in the PI3K/Akt signaling pathway in which D2Bwg1335e is involved. The inhibition of PI3K by LY294002 and Wortmannin can directly lead to a reduction in Akt phosphorylation and activity, subsequently inhibiting the downstream processes regulated by D2Bwg1335e. ZSTK474, another PI3K inhibitor, operates in a similar fashion, effectively blocking the kinase activity of PI3K and disrupting the intracellular signals that allow D2Bwg1335e to promote cell survival and growth. Triciribine specifically targets Akt, preventing its activation, which is essential for D2Bwg1335e to exert its influence on cellular mechanisms.
In addition to PI3K/Akt pathway inhibitors, Rapamycin and PP242 target the mTOR pathway, a downstream effect of PI3K/Akt signaling. Rapamycin inhibits the mTORC1 complex, while PP242 is more comprehensive, inhibiting both mTORC1 and mTORC2 complexes. These inhibitors disrupt the mTOR pathway's ability to regulate protein synthesis and cell growth, thereby inhibiting the function of D2Bwg1335e in these processes. Furthermore, MEK inhibitors such as PD98059, U0126, and SL327, impede the MAPK/ERK pathway, which can interact with PI3K/Akt signaling. The inhibition of MEK leads to decreased activation of ERK, which, in turn, affects the role of D2Bwg1335e in cell cycle regulation and cellular proliferation. SB203580 specifically inhibits p38 MAPK, potentially affecting the function of D2Bwg1335e in stress response and inflammatory signaling pathways. Lastly, Spautin-1 inhibits ubiquitin-specific peptidases, which could lead to the accumulation of proteins that regulate pathways in which D2Bwg1335e is involved, thereby indirectly inhibiting its function.
Items 1 to 10 of 11 total
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
LY 294002 | 154447-36-6 | sc-201426 sc-201426A | 5 mg 25 mg | $123.00 $400.00 | 148 | |
LY294002 is a specific inhibitor of phosphoinositide 3-kinases (PI3K), which can inhibit the PI3K/Akt signaling pathway. Since D2Bwg1335e is involved in this pathway, LY294002 inhibits the downstream effects mediated by D2Bwg1335e, leading to the inhibition of its function in promoting cell survival and growth. | ||||||
Wortmannin | 19545-26-7 | sc-3505 sc-3505A sc-3505B | 1 mg 5 mg 20 mg | $67.00 $223.00 $425.00 | 97 | |
Wortmannin is another potent inhibitor of PI3K. By binding irreversibly to PI3K, it inhibits the kinase activity, which is necessary for the PI3K/Akt pathway that D2Bwg1335e functions within. This results in the inhibition of D2Bwg1335e’s role in cellular processes such as glucose metabolism, protein synthesis, and cell cycle progression. | ||||||
Rapamycin | 53123-88-9 | sc-3504 sc-3504A sc-3504B | 1 mg 5 mg 25 mg | $63.00 $158.00 $326.00 | 233 | |
Rapamycin is an mTOR inhibitor. The mTOR pathway is a downstream target of PI3K/Akt signaling, where D2Bwg1335e operates. By inhibiting mTOR, Rapamycin can suppress the mTORC1 complex, leading to reduced protein synthesis and cell growth, thereby inhibiting the functional contributions of D2Bwg1335e to these processes. | ||||||
PP242 | 1092351-67-1 | sc-301606A sc-301606 | 1 mg 5 mg | $57.00 $172.00 | 8 | |
PP242 is a selective inhibitor of mTOR kinase activity. Unlike Rapamycin, PP242 inhibits both mTORC1 and mTORC2 complexes. This broad mTOR inhibition disrupts the cellular activities controlled by the mTOR pathway, including those influenced by D2Bwg1335e, resulting in the inhibition of its function related to cell growth and metabolism. | ||||||
Spautin-1 | 1262888-28-7 | sc-507306 | 10 mg | $168.00 | ||
Spautin-1 is a specific inhibitor of ubiquitin-specific peptidases, which are involved in the degradation of proteins via the ubiquitin-proteasome system. By inhibiting this system, Spautin-1 can lead to the accumulation of proteins that are typically degraded, which could include pathway regulators that control D2Bwg1335e's function, resulting in its inhibition. | ||||||
PD 98059 | 167869-21-8 | sc-3532 sc-3532A | 1 mg 5 mg | $40.00 $92.00 | 212 | |
PD98059 is a selective inhibitor of MEK, which is part of the MAPK/ERK pathway. This pathway can interact with PI3K/Akt signaling, where D2Bwg1335e is involved. By inhibiting MEK, PD98059 can suppress the ERK activation, potentially leading to the inhibition of D2Bwg1335e function in cell cycle regulation and cellular proliferation. | ||||||
U-0126 | 109511-58-2 | sc-222395 sc-222395A | 1 mg 5 mg | $64.00 $246.00 | 136 | |
U0126 is also a MEK inhibitor that functions similarly to PD98059, blocking the MAPK/ERK pathway. The inhibition of MEK leads to decreased ERK phosphorylation and activity, which can inhibit the cellular functions in which D2Bwg1335e is involved, specifically those pertaining to cell growth and survival signaling. | ||||||
SB 203580 | 152121-47-6 | sc-3533 sc-3533A | 1 mg 5 mg | $90.00 $349.00 | 284 | |
SB203580 is a specific inhibitor of p38 MAPK, another pathway that can cross-talk with PI3K/Akt signaling. The inhibition of p38 MAPK by SB203580 can result in the inhibition of stress response and inflammatory signaling pathways, which may influence the function of D2Bwg1335e, leading to its functional inhibition in these contexts. | ||||||
SL-327 | 305350-87-2 | sc-200685 sc-200685A | 1 mg 10 mg | $107.00 $332.00 | 7 | |
SL327 is an inhibitor of MEK1/2, which are upstream regulators of the ERK pathway. Since D2Bwg1335e is associated with the PI3K/Akt pathway that can be influenced by ERK signaling, inhibiting MEK1/2 with SL327 can inhibit the activation of ERK and thus inhibit the functions of D2Bwg1335e that are associated with cell proliferation and survival. | ||||||
Triciribine | 35943-35-2 | sc-200661 sc-200661A | 1 mg 5 mg | $104.00 $141.00 | 14 | |
Triciribine specifically inhibits the activation of Akt, a key component of the PI3K/Akt pathway. By preventing Akt phosphorylation and activation, Triciribine can inhibit the downstream functions of D2Bwg1335e that are dependent on this signaling pathway, particularly roles in cell survival, growth, and metabolism. | ||||||