D230039L06Rik Activators
Kif26b, a member of the kinesin family, plays a vital role in various cellular processes, including microtubule binding and motor activity, establishment of cell polarity, and positive regulation of cell-cell adhesion. Activation of Kif26b involves a complex interplay with various chemical activators targeting distinct cellular processes.
Paclitaxel and Epothilone B directly activate Kif26b by stabilizing microtubules, enhancing its motor activity and promoting intracellular transport. Lithium Chloride and Y-27632 stimulate Kif26b through inhibition of GSK-3β and ROCK, respectively, influencing its involvement in cell polarity and adhesion regulation. Indirect activators like XAV-939 and Dibenzazepine modulate Kif26b by inhibiting the Wnt/β-catenin pathway and Notch signaling, impacting its roles in cell polarity and adhesion. MG-132, Nocodazole, CHIR-99021, EHop-016, BIO, and Latrunculin A activate Kif26b through various mechanisms, showcasing its versatility in responding to diverse cellular cues. In conclusion, the comprehensive understanding of Kif26b activation reveals its pivotal role in microtubule dynamics and cellular processes. The intricate regulatory network involving various chemicals provides insights into potential strategies for modulating Kif26b function in physiological and pathological contexts.
SEE ALSO...
Items 1 to 10 of 12 total
Display:
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Taxol | 33069-62-4 | sc-201439D sc-201439 sc-201439A sc-201439E sc-201439B sc-201439C | 1 mg 5 mg 25 mg 100 mg 250 mg 1 g | $40.00 $73.00 $217.00 $242.00 $724.00 $1196.00 | 39 | |
Directly activates Kif26b by stabilizing microtubules, enhancing microtubule motor activity and promoting Kif26b-mediated intracellular transport. | ||||||
Lithium | 7439-93-2 | sc-252954 | 50 g | $214.00 | ||
Stimulates Kif26b through inhibition of GSK-3β, promoting Kif26b involvement in establishment of cell polarity and positive regulation of cell-cell adhesion. | ||||||
Epothilone B, Synthetic | 152044-54-7 | sc-203944 | 2 mg | $176.00 | ||
Directly activates Kif26b by stabilizing microtubules, enhancing microtubule motor activity and promoting Kif26b-mediated intracellular transport. | ||||||
XAV939 | 284028-89-3 | sc-296704 sc-296704A sc-296704B | 1 mg 5 mg 50 mg | $35.00 $115.00 $515.00 | 26 | |
Indirectly activates Kif26b by inhibiting the Wnt/β-catenin pathway, influencing Kif26b involvement in establishment of cell polarity and ureteric bud invasion. | ||||||
Dibenzazepine (Deshydroxy LY 411575) | 209984-56-5 | sc-207554 sc-207554A | 2 mg 5 mg | $100.00 $260.00 | 4 | |
Indirectly activates Kif26b by inhibiting Notch signaling, influencing Kif26b involvement in establishment of cell polarity and positive regulation of cell-cell adhesion. | ||||||
MG-132 [Z-Leu- Leu-Leu-CHO] | 133407-82-6 | sc-201270 sc-201270A sc-201270B | 5 mg 25 mg 100 mg | $56.00 $260.00 $980.00 | 163 | |
Activates Kif26b through proteasome inhibition, promoting Kif26b-mediated intracellular transport and involvement in diverse cellular processes. | ||||||
Y-27632, free base | 146986-50-7 | sc-3536 sc-3536A | 5 mg 50 mg | $182.00 $693.00 | 88 | |
Stimulates Kif26b by inhibiting ROCK, influencing Kif26b involvement in establishment of cell polarity and ureteric bud invasion. | ||||||
Nocodazole | 31430-18-9 | sc-3518B sc-3518 sc-3518C sc-3518A | 5 mg 10 mg 25 mg 50 mg | $58.00 $83.00 $140.00 $242.00 | 38 | |
Indirectly activates Kif26b by destabilizing microtubules, triggering Kif26b-mediated intracellular transport and involvement in diverse cellular processes. | ||||||
GSK-3 Inhibitor XVI | 252917-06-9 | sc-221691 sc-221691A | 5 mg 25 mg | $153.00 $520.00 | 4 | |
Stimulates Kif26b through inhibition of GSK-3β, promoting Kif26b involvement in establishment of cell polarity and positive regulation of cell-cell adhesion. | ||||||
EHop-016 | 1380432-32-5 | sc-497382 | 5 mg | $78.00 | ||
Directly activates Kif26b by inhibiting Rac1, enhancing microtubule motor activity and promoting Kif26b-mediated intracellular transport. | ||||||