D19Bwg1357e Activators
Pum3, a member of the Pumilio and Fem-3 mRNA-binding factor family, possesses distinctive features, including tandem pumilio homolog domains and the ability to bind DNA and RNA without sequence specificity. Involved in diverse biological processes, Pum3 plays a crucial role in cellular functions, and its dysregulation is linked to testicular germ cell tumors in mice. Activation of Pum3 involves a complex interplay with various chemical activators targeting distinct cellular processes.
Chemicals like Actinomycin D and Tunicamycin directly activate Pum3 by inducing RNA transcription inhibition and endoplasmic reticulum stress, respectively. Indirect activators, such as Etoposide and 5-Fluorouracil, induce DNA damage and interfere with DNA/RNA synthesis, triggering stress responses that lead to Pum3 upregulation. Stimulators like AICAR and 2-Deoxyglucose activate Pum3 through AMPK, influencing cellular energy status. The involvement of Pum3 in stress response pathways, including DNA repair and unfolded protein response, is evident in its activation by various chemicals. In conclusion, the diverse activators of Pum3 highlight its intricate regulatory network and its role in cellular stress responses and DNA damage repair. Understanding the nuanced mechanisms of Pum3 activation provides insights into potential avenues for manipulating its function in various biological processes.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Actinomycin D | 50-76-0 | sc-200906 sc-200906A sc-200906B sc-200906C sc-200906D | 5 mg 25 mg 100 mg 1 g 10 g | $74.00 $243.00 $731.00 $2572.00 $21848.00 | 53 | |
Directly activates Pum3 by inhibiting RNA transcription, inducing cellular stress that triggers Pum3 upregulation and engagement in biological processes. | ||||||
AICAR | 2627-69-2 | sc-200659 sc-200659A sc-200659B | 50 mg 250 mg 1 g | $65.00 $280.00 $400.00 | 48 | |
Stimulates Pum3 through AMP-activated protein kinase (AMPK) activation, influencing cellular energy status and promoting Pum3 involvement in diverse biological processes. | ||||||
Etoposide (VP-16) | 33419-42-0 | sc-3512B sc-3512 sc-3512A | 10 mg 100 mg 500 mg | $51.00 $231.00 $523.00 | 63 | |
Activates Pum3 by inducing DNA damage, leading to p53-dependent Pum3 upregulation and engagement in cellular processes associated with DNA repair and stress response. | ||||||
Fluorouracil | 51-21-8 | sc-29060 sc-29060A | 1 g 5 g | $37.00 $152.00 | 11 | |
Indirectly activates Pum3 by interfering with DNA and RNA synthesis, triggering cellular stress responses that lead to Pum3 upregulation and involvement in diverse biological processes. | ||||||
Tunicamycin | 11089-65-9 | sc-3506A sc-3506 | 5 mg 10 mg | $172.00 $305.00 | 66 | |
Directly activates Pum3 by inducing endoplasmic reticulum (ER) stress, promoting Pum3 engagement in cellular processes associated with unfolded protein response (UPR) and stress adaptation. | ||||||
Staurosporine | 62996-74-1 | sc-3510 sc-3510A sc-3510B | 100 µg 1 mg 5 mg | $82.00 $153.00 $396.00 | 113 | |
Activates Pum3 by promoting cellular stress through protein kinase inhibition, leading to Pum3 upregulation and involvement in cellular processes associated with stress response. | ||||||
Hydroxyurea | 127-07-1 | sc-29061 sc-29061A | 5 g 25 g | $78.00 $260.00 | 18 | |
Indirectly activates Pum3 by inducing replication stress, triggering Pum3 upregulation and engagement in biological processes associated with DNA repair and stress adaptation. | ||||||
2-Deoxy-D-glucose | 154-17-6 | sc-202010 sc-202010A | 1 g 5 g | $70.00 $215.00 | 26 | |
Stimulates Pum3 through AMP-activated protein kinase (AMPK) activation, influencing cellular energy status and promoting Pum3 involvement in diverse biological processes. | ||||||
Camptothecin | 7689-03-4 | sc-200871 sc-200871A sc-200871B | 50 mg 250 mg 100 mg | $58.00 $186.00 $94.00 | 21 | |
Activates Pum3 through topoisomerase I inhibition, inducing DNA damage and leading to p53-dependent Pum3 upregulation and engagement in cellular processes associated with stress response. | ||||||
Geldanamycin | 30562-34-6 | sc-200617B sc-200617C sc-200617 sc-200617A | 100 µg 500 µg 1 mg 5 mg | $39.00 $59.00 $104.00 $206.00 | 8 | |
Indirectly activates Pum3 by inhibiting Hsp90, triggering cellular stress responses that lead to Pum3 upregulation and involvement in diverse biological processes. | ||||||