Date published: 2025-10-11

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CysLT1 Receptor Inhibitors

CysLT1 Receptor Inhibitors represent a significant class of chemicals that interact with the CysLT1 receptor, a key component in the leukotriene pathway associated with inflammatory responses. These inhibitors encompass a range of compounds, each with a unique mechanism of interaction with the receptor or its associated pathways. Montelukast, Zafirlukast, and Pranlukast are prime examples, known for their selective binding to the CysLT1 receptor, effectively blocking the effects of leukotrienes. These compounds directly inhibit the receptor, preventing the usual biological responses mediated by leukotrienes such as bronchoconstriction, mucus secretion, and vascular permeability. In addition to direct antagonists, there are several compounds that indirectly influence the CysLT1 receptor. NSAIDs like Indomethacin, Aspirin, Ibuprofen, and Naproxen may modulate leukotriene synthesis, thereby affecting the receptor's activity. Corticosteroids such as Dexamethasone, Prednisone, and Hydrocortisone are also pivotal, as they can alter inflammatory pathways and potentially impact the synthesis or function of leukotrienes and their receptors. Additionally, Loratadine, an antihistamine, and Theophylline, a bronchodilator, are included for their potential indirect effects on the leukotriene pathway, which might influence the CysLT1 receptor activity.

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Items 11 to 20 of 21 total

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Product NameCAS #Catalog #QUANTITYPriceCitationsRATING

Indomethacin

53-86-1sc-200503
sc-200503A
1 g
5 g
$28.00
$37.00
18
(1)

NSAID that might modulate leukotriene pathway, affecting CysLT1 receptor.

Montelukast Dicyclohexylamine Salt

577953-88-9sc-211923
1 mg
$320.00
(0)

Montelukast Dicyclohexylamine Salt functions as a selective antagonist of the CysLT1 receptor, exhibiting unique binding dynamics that disrupt leukotriene signaling. Its structural conformation facilitates specific electrostatic interactions, enhancing receptor affinity. The compound's kinetic profile reveals a notable balance between binding strength and dissociation, allowing for transient modulation of receptor states. Additionally, its amphiphilic nature promotes effective integration into lipid bilayers, influencing membrane-associated processes.

Pranlukast hemihydrate

150821-03-7sc-215745
5 mg
$73.00
(1)

Pranlukast hemihydrate acts as a selective antagonist of the CysLT1 receptor, characterized by its unique ability to stabilize receptor conformations through specific hydrophobic interactions. This compound exhibits a distinct kinetic behavior, with a rapid association rate that allows for effective competition against endogenous ligands. Its solubility properties enhance its distribution in biological systems, facilitating interactions with membrane proteins and influencing downstream signaling pathways.

Aspirin

50-78-2sc-202471
sc-202471A
5 g
50 g
$20.00
$41.00
4
(1)

Can alter leukotriene synthesis, potentially influencing CysLT1 receptor.

Montelukast-d6, Sodium Salt

sc-218876
1 mg
$331.00
(0)

Montelukast-d6, Sodium Salt functions as a selective antagonist of the CysLT1 receptor, exhibiting unique binding dynamics that involve intricate hydrogen bonding and electrostatic interactions. This compound demonstrates a notable affinity for the receptor, leading to a prolonged dissociation time that enhances its competitive inhibition of leukotriene signaling. Its isotopic labeling provides insights into metabolic pathways, allowing for advanced tracking in biochemical studies.

Ibuprofen

15687-27-1sc-200534
sc-200534A
1 g
5 g
$52.00
$86.00
6
(0)

Might have an indirect impact on leukotriene pathway and CysLT1 receptor.

Naproxen

22204-53-1sc-200506
sc-200506A
1 g
5 g
$24.00
$40.00
(1)

NSAID that may affect leukotriene synthesis, influencing CysLT1 receptor.

Dexamethasone

50-02-2sc-29059
sc-29059B
sc-29059A
100 mg
1 g
5 g
$76.00
$82.00
$367.00
36
(1)

Corticosteroid that can modulate inflammatory pathways affecting CysLT1 receptor.

Prednisone

53-03-2sc-205816
sc-205816A
sc-205816B
1 g
5 g
25 g
$41.00
$133.00
$663.00
2
(1)

Can influence leukotriene pathway, potentially affecting CysLT1 receptor.

Hydrocortisone

50-23-7sc-300810
5 g
$100.00
6
(1)

Might modulate leukotriene synthesis and CysLT1 receptor activity.