Cyp4f14 Inhibitors
Chemical inhibitors of Cyp4f14 operate through a variety of mechanisms that ultimately reduce the availability of leukotriene substrates necessary for the protein's enzymatic activity. Montelukast and Zafirlukast, for instance, are leukotriene receptor antagonists which block the action of leukotrienes, leading to a decrease in Cyp4f14 function due to substrate unavailability. Similarly, Zileuton, as a 5-lipoxygenase inhibitor, impedes the production of leukotrienes, thereby limiting the substrates that Cyp4f14 can act upon. MK-886 takes a slightly different approach by inhibiting 5-lipoxygenase-activating protein (FLAP), which is crucial in the synthesis of leukotrienes, thus indirectly inhibiting Cyp4f14 activity by reducing the levels of its substrates. In parallel, natural compounds such as Quercetin and Esculetin exhibit inhibitory effects on the lipoxygenase pathway, leading to a decrease in leukotriene synthesis and, consequently, a reduction in Cyp4f14 activity.
Other inhibitors like Nordihydroguaiaretic acid and Masoprocol function as lipoxygenase inhibitors, thereby preventing the formation of leukotrienes and subsequently reducing Cyp4f14's enzymatic activity. Baicalein, specifically targeting 12-lipoxygenase, and Phenidone, inhibiting both cyclooxygenase and lipoxygenase enzymes, contribute to a decrease in leukotriene levels, which in turn limits the activity of Cyp4f14. Ebselen, a seleno-organic compound, also inhibits lipoxygenases, further contributing to the reduction of leukotriene synthesis and the consequent inhibition of Cyp4f14.
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Montelukast Sodium | 151767-02-1 | sc-202231 sc-202231A sc-202231B | 10 mg 25 mg 250 mg | $50.00 $83.00 $158.00 | 5 | |
Montelukast is a leukotriene receptor antagonist that blocks the action of leukotrienes, which are involved in immune system signaling. By inhibiting leukotriene receptors, Montelukast reduces the activity of enzymes like Cyp4f14 that metabolize leukotrienes, leading to a decrease in Cyp4f14 function due to substrate unavailability. | ||||||
Zileuton | 111406-87-2 | sc-204417 sc-204417A sc-204417B sc-204417C | 10 mg 50 mg 1 g 75 g | $82.00 $301.00 $362.00 $1229.00 | 8 | |
Zileuton is a 5-lipoxygenase inhibitor that impedes the production of leukotrienes by inhibiting the enzyme 5-lipoxygenase, thus reducing the availability of leukotriene substrates for Cyp4f14, which in turn inhibits the protein's activity as it has fewer substrates to act upon. | ||||||
Quercetin | 117-39-5 | sc-206089 sc-206089A sc-206089E sc-206089C sc-206089D sc-206089B | 100 mg 500 mg 100 g 250 g 1 kg 25 g | $11.00 $17.00 $108.00 $245.00 $918.00 $49.00 | 33 | |
Quercetin is a flavonoid that shows inhibition of the 5-lipoxygenase pathway and consequently reduces the production of leukotrienes. This reduction in leukotriene synthesis diminishes the enzymatic activity of Cyp4f14 as a result of substrate depletion. | ||||||
MK-886 sodium salt | 118427-55-7 | sc-200608B sc-200608 sc-200608A | 1 mg 5 mg 25 mg | $46.00 $93.00 $371.00 | 3 | |
MK-886 is an inhibitor of 5-lipoxygenase-activating protein (FLAP), which is necessary for the synthesis of leukotrienes. By inhibiting FLAP, MK-886 reduces leukotriene levels, indirectly inhibiting Cyp4f14 activity by limiting its substrate pool. | ||||||
Esculetin | 305-01-1 | sc-200486 sc-200486A | 1 g 5 g | $43.00 $208.00 | 7 | |
Esculetin acts as a lipoxygenase inhibitor, thereby decreasing the production of leukotrienes. By reducing the leukotriene synthesis, Esculetin limits the available substrates for Cyp4f14, which leads to an inhibition of the protein's metabolic function. | ||||||
NDGA (Nordihydroguaiaretic acid) | 500-38-9 | sc-200487 sc-200487A sc-200487B | 1 g 5 g 25 g | $107.00 $376.00 $2147.00 | 3 | |
Nordihydroguaiaretic acid is a lipoxygenase inhibitor that prevents the formation of leukotrienes. Inhibiting lipoxygenase results in decreased availability of leukotriene substrates for Cyp4f14, thus functionally inhibiting the protein. | ||||||
Baicalein | 491-67-8 | sc-200494 sc-200494A sc-200494B sc-200494C | 10 mg 100 mg 500 mg 1 g | $31.00 $41.00 $159.00 $286.00 | 12 | |
Baicalein is known to inhibit 12-lipoxygenase, consequently reducing leukotriene synthesis. The reduction of leukotriene production limits the substrates accessible for Cyp4f14, consequently inhibiting its activity. | ||||||
Phenidone | 92-43-3 | sc-200508 | 5 g | $31.00 | ||
Phenidone is an inhibitor of both cyclooxygenase and lipoxygenase enzymes. By inhibiting these enzymes, Phenidone decreases the levels of leukotrienes, thereby reducing the activity of Cyp4f14 through substrate limitation. | ||||||
Zafirlukast | 107753-78-6 | sc-204942 sc-204942A | 10 mg 100 mg | $36.00 $171.00 | 1 | |
Zafirlukast is another leukotriene receptor antagonist that prevents leukotrienes from binding to their receptors. This blockade leads to reduced metabolism of leukotrienes by Cyp4f14, functionally inhibiting the protein by preventing it from acting on its intended substrates. | ||||||
Ebselen | 60940-34-3 | sc-200740B sc-200740 sc-200740A | 1 mg 25 mg 100 mg | $32.00 $133.00 $449.00 | 5 | |
Ebselen is a seleno-organic compound that has been found to inhibit various enzymes including lipoxygenases. By inhibiting lipoxygenases, Ebselen reduces leukotriene synthesis, leading to a functional inhibition of Cyp4f14 due to lack of substrate. | ||||||