Molecular structure of Phenidone, CAS Number: 92-43-3
Phenidone (CAS 92-43-3)
Alternate Names:
1-Phenyl-3-pyrazolidinone
Application:
Phenidone is a dual LO (lipoxygenase) and Cox (cyclooxygenase) inhibitor
CAS Number:
92-43-3
Molecular Weight:
162.2
Molecular Formula:
C9H10N2O
Supplemental Information:
This is classified as a Dangerous Good for transport and may be subject to additional shipping charges.
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
Phenidone inhibits both the LO (lipoxygenase) and Cox (cyclooxygenase) pathways, the synthesis of Fos-related antigen protein, and is described as an anti-inflammatory and anti-oxidant compound. Studies indicate that Phenidone decreases the oxidative affects of xanthine/xanthine oxidase, Hydrogen Peroxide (sc-203336), Arachidonic Acid(sc-200770), and Fe2+ ascorbic acid. Mouse cortical research reports that Phenidone weakens oxygen/glucose deprivation-induced neurotoxicity through apoptotic and antioxidant action. Phenidone has been shown to block neurotoxicity induced by kainate, and weakens oxidative stress induced by lipopolysaccharide.
Phenidone (CAS 92-43-3) References
- Phenidone attenuates oxygen/glucose deprivation-induced neurotoxicity by antioxidant and antiapoptotic action in mouse cortical cultures. | Wie, MB., et al. 1999. Neurosci Lett. 272: 91-4. PMID: 10507549
- Phenidone prevents kainate-induced neurotoxicity via antioxidant mechanisms. | Kim, HC., et al. 2000. Brain Res. 874: 15-23. PMID: 10936219
- The lipoxygenase inhibitor phenidone protects against proteinuria and stroke in stroke-prone spontaneously hypertensive rats. | Munsiff, AV., et al. 1992. Am J Hypertens. 5: 56-63. PMID: 1550666
- Synthesis and biological evaluation of new phenidone analogues as potential dual cyclooxygenase (COX-1 and COX-2) and human lipoxygenase (5-LOX) inhibitors. | Cusan, C., et al. 2005. Farmaco. 60: 7-13. PMID: 15652362
- Phenidone, a dual inhibitor of cyclooxygenases and lipoxygenases, ameliorates rat paralysis in experimental autoimmune encephalomyelitis by suppressing its target enzymes. | Moon, C., et al. 2005. Brain Res. 1035: 206-10. PMID: 15722060
- Anti-inflammatory and anti-oxidant activity of a new class of phenyl-pyrazolone derivatives. | Cusan, C., et al. 2006. Curr Drug Discov Technol. 3: 67-73. PMID: 16712464
- Mechanisms involved in the effects of phenidone, diclofenac and ethacrynic acid in rat uterus in vitro. | Pérez Vallina, JR., et al. 1991. Gen Pharmacol. 22: 435-41. PMID: 1714410
- Phenidone protects the nigral dopaminergic neurons from LPS-induced neurotoxicity. | Li, Z., et al. 2008. Neurosci Lett. 445: 1-6. PMID: 18760329
- Activity of the lipoxygenase inhibitor 1-phenyl-3-pyrazolidinone (phenidone) and derivatives on the inhibition of adhesion molecule expression on human umbilical vascular endothelial cells. | Schroeder, TH., et al. 2008. Biologics. 2: 151-60. PMID: 19707438
- Effects of phenidone (DuCLOX-2/5 inhibitor) against N-methyl-N-nitrosourea induced mammary gland carcinoma in albino rats. | Gautam, S., et al. 2018. Toxicol Appl Pharmacol. 351: 57-63. PMID: 29679652
- Oxidation of phenidone and BW755C by prostaglandin endoperoxide synthetase. | Marnett, LJ., et al. 1982. J Biol Chem. 257: 6957-64. PMID: 6806260
- The lipoxygenase inhibitor phenidone is a potent hypotensive agent in the spontaneously hypertensive rat. | Stern, N., et al. 1993. Am J Hypertens. 6: 52-8. PMID: 8427662
- Phenidone blocks the increases of proenkephalin and prodynorphin gene expression induced by kainic acid in rat hippocampus: involvement of Fos-related antigene protein. | Kim, HC., et al. 1998. Brain Res. 782: 337-42. PMID: 9519284
Inhibitor of:
5-LO, Cox, Cyp4f14, and LO.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Phenidone, 5 g | sc-200508 | 5 g | $31.00 |