Date published: 2025-12-18

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CYP4A32 Inhibitors

CYP4A32 Inhibitors refers to a group of compounds that exhibit the ability to selectively inhibit the enzymatic activity of Cytochrome P450 4A32 (CYP4A32). CYP4A32 is a member of the cytochrome P450 superfamily of enzymes, primarily found in the liver and kidney tissues of certain mammalian species, including humans. This particular isoform is notable for its role in the metabolism of long-chain fatty acids and eicosanoids, which are lipid signaling molecules involved in various physiological processes, including inflammation and blood pressure regulation. CYP4A32 inhibitors are characterized by their capacity to interfere with the catalytic function of the CYP4A32 enzyme, primarily by binding to its heme group. This binding interaction disrupts the enzyme's ability to metabolize fatty acids and eicosanoids, which are crucial for the biosynthesis of important bioactive lipid molecules. By inhibiting CYP4A32, these compounds modulate the homeostasis of these lipid signaling molecules, resulting in downstream effects on various biological pathways. Consequently, CYP4A32 inhibitors have been of significant interest in the field of pharmacology and chemical biology, as they provide valuable tools for studying the roles of specific eicosanoids and fatty acids in physiological processes, including inflammation and cardiovascular regulation.In summary, CYP4A32 inhibitors constitute a chemical class that exerts their influence by selectively blocking the enzymatic activity of CYP4A32, a key enzyme involved in the metabolism of long-chain fatty acids and eicosanoids. Their mode of action, centered on disrupting the heme group of the enzyme, allows researchers to manipulate lipid signaling pathways and explore the intricate roles of these molecules in various physiological contexts. While these inhibitors hold applications in biomedical research, it's essential to emphasize that their primary significance lies in advancing our understanding of lipid metabolism and its impact on cellular functions, rather than as direct agents.
Product NameCAS #Catalog #QUANTITYPriceCitationsRATING

Ketoconazole

65277-42-1sc-200496
sc-200496A
50 mg
500 mg
$62.00
$260.00
21
(1)

Ketoconazole inhibits CYP4A32 by blocking its active site, blocking the enzyme from metabolizing its substrates, including fatty acids and eicosanoids. This inhibition reduces the production of bioactive lipids involved in inflammation and hypertension.

Miconazole

22916-47-8sc-204806
sc-204806A
1 g
5 g
$65.00
$157.00
2
(1)

Miconazole is an antifungal drug that also inhibits CYP4A32 by binding to its heme group, disrupting its catalytic function. This inhibition reduces the metabolism of arachidonic acid and related compounds, leading to decreased inflammation and vasoconstriction.

Clotrimazole

23593-75-1sc-3583
sc-3583A
100 mg
1 g
$41.00
$56.00
6
(2)

Clotrimazole inhibits CYP4A32 by interfering with its heme group, thereby reducing the enzyme's ability to metabolize fatty acids and eicosanoids. This inhibition contributes to the regulation of blood pressure and inflammation.

Econazole

27220-47-9sc-279013
5 g
$240.00
(0)

Econazole acts as an inhibitor of CYP4A32 by binding to its heme group, impairing the enzyme's ability to metabolize fatty acids and eicosanoids. This inhibition helps regulate blood pressure and inflammation.

Fluconazole

86386-73-4sc-205698
sc-205698A
500 mg
1 g
$53.00
$84.00
14
(1)

Fluconazole inhibits CYP4A32 by interfering with its heme group, disrupting its catalytic function in fatty acid and eicosanoid metabolism, thereby modulating blood pressure and inflammation.

Itraconazole

84625-61-6sc-205724
sc-205724A
50 mg
100 mg
$76.00
$139.00
23
(1)

Itraconazole inhibits CYP4A32 by binding to its heme group, impeding the enzyme's ability to metabolize fatty acids and eicosanoids, ultimately reducing inflammation and hypertension.

Imidazole

288-32-4sc-204776
sc-204776A
sc-204776B
sc-204776C
25 g
100 g
1 kg
5 kg
$26.00
$55.00
$82.00
$336.00
2
(2)

Imidazole is a broad-spectrum CYP inhibitor, including CYP4A32, by coordinating with the enzyme's heme group, inhibiting the metabolism of fatty acids and eicosanoids.

Etomidate

33125-97-2sc-203577
10 mg
$124.00
(0)

Etomidate inhibits CYP4A32 by binding to its heme group, impeding the enzyme's ability to metabolize fatty acids and eicosanoids, contributing to the regulation of blood pressure and inflammation.

Sulconazole

61318-90-9sc-338599
100 mg
$1000.00
1
(0)

Sulconazole inhibits CYP4A32 by binding to its heme group, disrupting its catalytic function, and reducing the metabolism of fatty acids and eicosanoids, helping to regulate blood pressure and inflammation.

Bifonazole

60628-96-8sc-204652
sc-204652A
1 g
5 g
$35.00
$154.00
1
(1)

Bifonazole acts as a CYP4A32 inhibitor by binding to its heme group, interfering with the enzyme′s role in fatty acid and eicosanoid metabolism, ultimately contributing to the regulation of blood pressure and inflammation.