Bifonazole (CAS 60628-96-8)

Bifonazole is an imidazole antifungal agent widely studied for its unique mode of action and applications in fungal research. It functions by inhibiting the enzyme lanosterol 14α-demethylase, a key component in the ergosterol biosynthesis pathway. Ergosterol is an essential sterol in fungal cell membranes, and its depletion disrupts membrane integrity and function, leading to fungal cell death. In scientific research, bifonazole is utilized to investigate the mechanisms of fungal resistance, particularly focusing on mutations in the target enzyme that confer reduced susceptibility. This research is critical for understanding the adaptive responses of fungi to antifungal pressure and for developing strategies to counteract resistance. Additionally, bifonazole is employed in studies examining the regulation of the ergosterol biosynthesis pathway and its role in maintaining cell membrane structure and function. Researchers also use bifonazole to explore its effects on fungal growth and morphology, providing insights into the cellular processes affected by membrane disruption. Furthermore, bifonazole serves as a tool in pharmacokinetic and pharmacodynamic studies, where its absorption, distribution, metabolism, and elimination are analyzed to understand the dynamics of antifungal agents. Overall, bifonazole′s specificity and efficacy make it a valuable compound in advancing our knowledge of fungal biology and antifungal mechanisms.