Molecular structure of Etomidate, CAS Number: 33125-97-2
Etomidate (CAS 33125-97-2)
Alternate Names:
(R)-1-(1-Phenylethyl)-1H-imidazole-5-carboxylic acid ethyl ester
Application:
Etomidate is a GABAA receptors agonist
CAS Number:
33125-97-2
Molecular Weight:
244.29
Molecular Formula:
C14H16N2O2
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
Etomidate is a general anesthetic with GABA modulatory and GABA-mimetic actions. Interacts selectively with β2- and β3-subunit containing GABAA receptors. Etomidate is a short acting and potent hypnotic; low toxicity.
Etomidate (CAS 33125-97-2) References
- Etomidate reduces glutamate uptake in rat cultured glial cells: involvement of PKA. | Räth, M., et al. 2008. Br J Pharmacol. 155: 925-33. PMID: 19002104
- Etomidate unmasks intraadrenal regulation of steroidogenesis and proliferation in adrenal cortical cell lines. | Hahner, S., et al. 2010. Horm Metab Res. 42: 528-34. PMID: 20352599
- Etomidate induces cytotoxic effects and gene expression in a murine leukemia macrophage cell line (RAW264.7). | Wu, RS., et al. 2011. Anticancer Res. 31: 2203-8. PMID: 21737642
- Enhanced tonic inhibition influences the hypnotic and amnestic actions of the intravenous anesthetics etomidate and propofol. | Kretschmannova, K., et al. 2013. J Neurosci. 33: 7264-73. PMID: 23616535
- Etomidate increases mortality in septic rats through inhibition of nuclear factor kappa-B rather than by causing adrenal insufficiency. | Zhang, Y., et al. 2015. J Surg Res. 193: 399-406. PMID: 25103639
- Etomidate, propofol and diazepam potentiate GABA-evoked GABAA currents in a cell line derived from human glioblastoma. | Babateen, O., et al. 2015. Eur J Pharmacol. 748: 101-7. PMID: 25510230
- Etomidate Mitigates Lipopolysaccharide-Induced CD14 and TREM-1 Expression, NF-κB Activation, and Pro-inflammatory Cytokine Production in Rat Macrophages. | Liu, M., et al. 2016. Inflammation. 39: 327-335. PMID: 26383906
- Etomidate exposure in early infant mice (P10) does not induce apoptosis or affect behaviour. | Nyman, Y., et al. 2016. Acta Anaesthesiol Scand. 60: 588-96. PMID: 26763687
- Etomidate Suppresses Invasion and Migration of Human A549 Lung Adenocarcinoma Cells. | Chu, CN., et al. 2019. Anticancer Res. 39: 215-223. PMID: 30591461
- Effects of cyclosporin A pre-treatment combined with etomidate post-treatment on lung injury induced by limb ischemia-reperfusion in rats. | Zou, H. and Sun, X. 2020. J Int Med Res. 48: 300060520934627. PMID: 32674636
- Etomidate alleviates cardiac dysfunction, fibrosis and oxidative stress in rats with myocardial ischemic reperfusion injury. | Xie, D., et al. 2020. Ann Transl Med. 8: 1181. PMID: 33241030
- Etomidate ameliorated advanced glycation end-products (AGEs)-induced reduction of extracellular matrix genes expression in chondrocytes. | Sun, X., et al. 2021. Bioengineered. 12: 4191-4200. PMID: 34308765
- Etomidate affects spatial learning and memory and neuronal apoptosis of rats via MAPK/ERK pathway. | Xie, S., et al. 2022. Am J Transl Res. 14: 5823-5832. PMID: 36105027
- Etomidate elicits anti-tumor capacity by disrupting the JAK2/STAT3 signaling pathway in hepatocellular carcinoma. | Xu, J., et al. 2023. Cancer Lett. 552: 215970. PMID: 36265652
- The effects of etomidate on expression of high mobility group box 1 via the nuclear factor kappa B pathway in rat model of sepsis. | Park, YJ., et al. 2023. Libyan J Med. 18: 2182683. PMID: 36855243
Inhibitor of:
3β-HSD, 3β-HSD2, Cortisol, CYP11A1, CYP11B, CYP11B1, Cyp21a1, CYP21A2, EG434676, Fdx1, GABAA Rβ2, GLCCI1, Gonadotropin α, MC2-R, SerpinA6, StAR, and StARD5.Activator of:
11β-HSD2, CYP11B2, GABA (gamma-aminobutyric acid type receptor), GABA Receptor, GABAA R α 1, GABAA R α 2, GABAA R β 3, GABAA Rε, GABAA Rρ3, GABAA Rp, MRAP, and SHISA7.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Etomidate, 10 mg | sc-203577 | 10 mg | $126.00 |