CYP4A22 Activators
Cytochrome P450 4A22 (CYP4A22) is a member of the cytochrome P450 (CYP) enzyme family, a diverse group of enzymes that play a crucial role in the oxidation of organic substances. CYP4A22 is specifically involved in the metabolism of fatty acids, particularly in the hydroxylation of medium and long-chain fatty acids. This reaction is important for the breakdown and subsequent utilization or storage of fatty acids within the body.
CYP4A22 is expressed in the liver, which is the central organ for metabolic regulation, including lipid metabolism. The activity of CYP4A22 can influence the levels of various lipid species and has implications in energy homeostasis. Due to its role in lipid metabolism, CYP4A22 may be involved in pathophysiological conditions related to metabolic disorders, such as obesity, diabetes, and non-alcoholic fatty liver disease.The expression of CYP4A22 is regulated by peroxisome proliferator-activated receptors (PPARs), particularly PPARα, which is activated by fatty acids and fibrate drugs. Upon activation, PPARα binds to the peroxisome proliferator response element (PPRE) in the promoter region of genes like CYP4A22, leading to their transcriptional activation.
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Items 1 to 10 of 11 total
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Fenofibrate | 49562-28-9 | sc-204751 | 5 g | $41.00 | 9 | |
Can also activate PPARα leading to the upregulation of P450 enzymes including CYP4A22. | ||||||
WY 14643 | 50892-23-4 | sc-203314 | 50 mg | $136.00 | 7 | |
A PPARα agonist known to induce the expression of P450 enzymes by activating the receptor, which could increase CYP4A22 levels. | ||||||
Bezafibrate | 41859-67-0 | sc-204650B sc-204650 sc-204650A sc-204650C | 500 mg 1 g 5 g 10 g | $31.00 $46.00 $122.00 $204.00 | 5 | |
Another PPARα agonist that could stimulate CYP4A22 expression as part of its lipid-regulating effects. | ||||||
Gemfibrozil | 25812-30-0 | sc-204764 sc-204764A | 5 g 25 g | $66.00 $267.00 | 2 | |
May induce CYP4A22 through PPARα activation, affecting lipid metabolism. | ||||||
Ciprofibrate | 52214-84-3 | sc-204689 sc-204689A | 25 mg 100 mg | $58.00 $172.00 | ||
Could potentially induce CYP4A22 expression by PPARα-mediated mechanisms. | ||||||
Eicosa-5Z,8Z,11Z,14Z,17Z-pentaenoic Acid (20:5, n-3) | 10417-94-4 | sc-200766 sc-200766A | 100 mg 1 g | $104.00 $431.00 | ||
An omega-3 fatty acid that might induce CYP4A22 expression through PPARα activation. | ||||||
Docosa-4Z,7Z,10Z,13Z,16Z,19Z-hexaenoic Acid (22:6, n-3) | 6217-54-5 | sc-200768 sc-200768A sc-200768B sc-200768C sc-200768D | 100 mg 1 g 10 g 50 g 100 g | $94.00 $210.00 $1779.00 $8021.00 $16657.00 | 11 | |
Another omega-3 fatty acid which could modulate CYP4A22 levels via PPARα. | ||||||
Linoleic Acid | 60-33-3 | sc-200788 sc-200788A sc-200788B sc-200788C | 100 mg 1 g 5 g 25 g | $34.00 $64.00 $166.00 $281.00 | 4 | |
May induce CYP4A22 expression due to its role as a substrate for the enzyme, potentially upregulating its own metabolism. | ||||||
Arachidonic Acid (20:4, n-6) | 506-32-1 | sc-200770 sc-200770A sc-200770B | 100 mg 1 g 25 g | $92.00 $240.00 $4328.00 | 9 | |
As a substrate of CYP4A22, it could lead to increased expression of the enzyme to facilitate its metabolism. | ||||||
Bis(2-ethylhexyl) phthalate | 117-81-7 | sc-254975 | 1 g | $57.00 | 2 | |
Known to affect the expression of various P450 enzymes, could influence CYP4A22 expression. | ||||||