CYP4A22 Activators

Cytochrome P450 4A22 (CYP4A22) is a member of the cytochrome P450 (CYP) enzyme family, a diverse group of enzymes that play a crucial role in the oxidation of organic substances. CYP4A22 is specifically involved in the metabolism of fatty acids, particularly in the hydroxylation of medium and long-chain fatty acids. This reaction is important for the breakdown and subsequent utilization or storage of fatty acids within the body.

CYP4A22 is expressed in the liver, which is the central organ for metabolic regulation, including lipid metabolism. The activity of CYP4A22 can influence the levels of various lipid species and has implications in energy homeostasis. Due to its role in lipid metabolism, CYP4A22 may be involved in pathophysiological conditions related to metabolic disorders, such as obesity, diabetes, and non-alcoholic fatty liver disease.The expression of CYP4A22 is regulated by peroxisome proliferator-activated receptors (PPARs), particularly PPARα, which is activated by fatty acids and fibrate drugs. Upon activation, PPARα binds to the peroxisome proliferator response element (PPRE) in the promoter region of genes like CYP4A22, leading to their transcriptional activation.