CYP4A14 Inhibitors
CYP4A14 inhibitors are a class of chemical compounds designed to selectively target and inhibit the activity of the enzyme cytochrome P450 4A14 (CYP4A14). Cytochrome P450 enzymes are a superfamily of heme-containing proteins found in various tissues throughout the body, including the liver. These enzymes play a crucial role in the metabolism of endogenous compounds, drugs, and xenobiotics. CYP4A14, specifically, is a member of the CYP4 family and is primarily expressed in the liver and kidneys of mammals. It is involved in the oxidation of fatty acids and other lipids, playing a significant role in lipid metabolism.
Inhibition of CYP4A14 can have implications for understanding lipid metabolism and the regulation of fatty acid levels in the body. These inhibitors are valuable tools in both laboratory research and drug development. Scientists use them to study the precise function of CYP4A14 and its role in lipid homeostasis. By selectively inhibiting this enzyme, researchers can investigate its effects on fatty acid metabolism and gain insights into potential research strategies for conditions related to lipid disorders or metabolic diseases. Additionally, CYP4A14 inhibitors may find applications in the development of drugs targeting specific pathways involving lipid metabolism and inflammation.
SEE ALSO...
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Ketoconazole | 65277-42-1 | sc-200496 sc-200496A | 50 mg 500 mg | $63.00 $265.00 | 21 | |
Ketoconazole may inhibit CYP4A14 by competitively binding to the heme iron of the cytochrome P450 active site. | ||||||
Miconazole | 22916-47-8 | sc-204806 sc-204806A | 1 g 5 g | $66.00 $160.00 | 2 | |
Miconazole inhibits various cytochrome P450 enzymes and could decrease CYP4A14 expression by interfering with its enzymatic activity. | ||||||
Clotrimazole | 23593-75-1 | sc-3583 sc-3583A | 100 mg 1 g | $42.00 $57.00 | 6 | |
As an imidazole derivative, clotrimazole has the potential to inhibit CYP4A14 by binding to its heme group. | ||||||
Fluconazole | 86386-73-4 | sc-205698 sc-205698A | 500 mg 1 g | $54.00 $84.00 | 14 | |
Fluconazole selectively inhibits fungal cytochrome P450 enzymes, potentially affecting the CYP4A14 enzyme by a similar mechanism. | ||||||
Sulconazole | 61318-90-9 | sc-338599 | 100 mg | $1000.00 | 1 | |
Sulconazole might inhibit CYP4A14 activity through its action as a potent inhibitor of certain P450 enzymes. | ||||||
Econazole | 27220-47-9 | sc-279013 | 5 g | $240.00 | ||
Econazole's broad-spectrum antifungal activity includes inhibition of some mammalian cytochrome P450 enzymes, possibly including CYP4A14. | ||||||
Imidazole | 288-32-4 | sc-204776 sc-204776A sc-204776B sc-204776C | 25 g 100 g 1 kg 5 kg | $27.00 $56.00 $84.00 $343.00 | 2 | |
The parent compound of many antifungal agents, imidazole, may inhibit CYP4A14 directly by interacting with the enzyme's heme iron. | ||||||
Itraconazole | 84625-61-6 | sc-205724 sc-205724A | 50 mg 100 mg | $78.00 $142.00 | 23 | |
Itraconazole's mechanism of action includes inhibition of cytochrome P450-dependent enzymes, which may decrease CYP4A14 activity. | ||||||
Posaconazole | 171228-49-2 | sc-212571 | 1 mg | $353.00 | 7 | |
Posaconazole, an antifungal agent, may inhibit CYP4A14 by binding to the cytochrome P450 active site. | ||||||
Isavuconazole | 241479-67-4 | sc-488328 | 1 mg | $430.00 | 2 | |
Isavuconazole inhibits several cytochrome P450 enzymes and could potentially inhibit CYP4A14 by a similar mechanism. | ||||||