CYP4A14 Activators
CYP4A14 activators belong to a class of chemical compounds that specifically target and modulate the activity of the cytochrome P450 4A14 enzyme. Cytochrome P450 enzymes play a crucial role in the metabolism of endogenous and exogenous compounds in the liver. The CYP4A14 isoform, in particular, is a member of the 4A subfamily of cytochrome P450 enzymes and is predominantly expressed in the liver, where it contributes to the oxidative metabolism of fatty acids. Activators of CYP4A14 are designed to enhance the catalytic activity of this enzyme, leading to an increased rate of fatty acid oxidation.
These activators typically exert their effects by binding to specific sites on the CYP4A14 enzyme, inducing a conformational change that enhances its catalytic efficiency. The activation of CYP4A14 is of particular interest due to its involvement in the oxidation of long-chain fatty acids, which are essential components of cellular membranes and play a crucial role in energy metabolism. By influencing the activity of CYP4A14, these activators have the potential to modulate lipid homeostasis and impact various physiological processes. Research in this area aims to elucidate the molecular mechanisms underlying CYP4A14 activation and its downstream effects on lipid metabolism, providing valuable insights into the regulation of key biochemical pathways and contributing to a deeper understanding of the role of cytochrome P450 enzymes in cellular function.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Arachidonic Acid (20:4, n-6) | 506-32-1 | sc-200770 sc-200770A sc-200770B | 100 mg 1 g 25 g | $92.00 $240.00 $4328.00 | 9 | |
A polyunsaturated fatty acid involved in eicosanoid synthesis, potentially activating CYP4A14 through direct substrate involvement. | ||||||
Clofibrate | 637-07-0 | sc-200721 | 1 g | $33.00 | ||
A fibric acid derivative that activates cytochrome P450 enzymes involved in fatty acid metabolism, potentially leading to CYP4A14 activation. | ||||||
WY 14643 | 50892-23-4 | sc-203314 | 50 mg | $136.00 | 7 | |
A PPARα agonist that may indirectly activate CYP4A14 by modulating the PPARα-mediated pathways governing cytochrome P450 expression. | ||||||
Aroclor 1254 | 11097-69-1 | sc-257096 | 50 mg | $143.00 | 1 | |
A mixture of PCBs known to induce certain cytochrome P450 enzymes, potentially leading to activation of CYP4A14. | ||||||
Dexamethasone | 50-02-2 | sc-29059 sc-29059B sc-29059A | 100 mg 1 g 5 g | $91.00 $139.00 $374.00 | 36 | |
A glucocorticoid that activates the expression of various cytochrome P450 enzymes, potentially including CYP4A14, through transcriptional regulation. | ||||||
Retinoic Acid, all trans | 302-79-4 | sc-200898 sc-200898A sc-200898B sc-200898C | 500 mg 5 g 10 g 100 g | $66.00 $325.00 $587.00 $1018.00 | 28 | |
A regulator of gene expression, including some cytochrome P450 enzymes, potentially activating CYP4A14 through transcriptional control. | ||||||
Benzene | 71-43-2 | sc-239290 | 1 L | $79.00 | ||
Benzene exposure is linked to changes in the expression of some cytochrome P450 enzymes, potentially activating CYP4A14. | ||||||
Nicotinic Acid | 59-67-6 | sc-205768 sc-205768A | 250 g 500 g | $62.00 $124.00 | 1 | |
Niacin is suggested to influence PPARα activity, potentially indirectly activating CYP4A14 through modulation of PPARα-mediated pathways. | ||||||
Triclosan | 3380-34-5 | sc-220326 sc-220326A | 10 g 100 g | $141.00 $408.00 | ||
An antibacterial agent activating the expression of some cytochrome P450 enzymes, potentially leading to activation of CYP4A14. | ||||||