Molecular structure of Posaconazole, CAS Number: 171228-49-2
Posaconazole (CAS 171228-49-2)
See product citations (7)
Alternate Names:
Noxafil
Application:
Posaconazole is a triazole anti-fungal
CAS Number:
171228-49-2
Purity:
≥99%
Molecular Weight:
700.78
Molecular Formula:
C37H42F2N8O4
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
Posaconazole is a triazole anti-fungal. Posaconazole is an inhibitor of CYP51A1. it functions by inhibiting the activity of the 14-alpha demethylase enzyme. This particular enzyme plays a role in the synthesis of ergosterol, a vital component of the fungal cell wall. By blocking this enzyme, Posaconazole effectively hinders the conversion of lanosterol into ergosterol, thereby preventing the formation of functional fungal cell walls. Consequently, the integrity and permeability of the fungal cell membranes are compromised, resulting in the lysis of the fungal cells.
Posaconazole (CAS 171228-49-2) References
- In vitro susceptibility of Aspergillus fumigatus to isavuconazole: correlation with itraconazole, voriconazole, and posaconazole. | Gregson, L., et al. 2013. Antimicrob Agents Chemother. 57: 5778-80. PMID: 24041890
- Antifungal azoles itraconazole and posaconazole exhibit potent in vitro antiviral activity against clinical isolates of parechovirus A3 (Picornaviridae). | Rhoden, E., et al. 2018. Antiviral Res. 149: 75-77. PMID: 29155163
- Posaconazole inhibits dengue virus replication by targeting oxysterol-binding protein. | Meutiawati, F., et al. 2018. Antiviral Res. 157: 68-79. PMID: 29981375
- The Effect of Posaconazole, Itraconazole and Voriconazole in the Culture Medium on Aspergillus fumigatus Triazole Resistance. | Mroczyńska, M., et al. 2020. Microorganisms. 8: PMID: 32093114
- Luliconazole, a highly effective imidazole, against Fusarium species complexes. | Gharaghani, M., et al. 2020. Med Microbiol Immunol. 209: 603-612. PMID: 32253502
- Novel High-Drug-Loaded Amorphous Dispersion Tablets of Posaconazole; In Vivo and In Vitro Assessment. | Mudie, DM., et al. 2020. Mol Pharm. 17: 4463-4472. PMID: 32835489
- Structures of ABCB4 provide insight into phosphatidylcholine translocation. | Nosol, K., et al. 2021. Proc Natl Acad Sci U S A. 118: PMID: 34385322
- Benzimidazoles induce concurrent apoptosis and pyroptosis of human glioblastoma cells via arresting cell cycle. | Ren, LW., et al. 2022. Acta Pharmacol Sin. 43: 194-208. PMID: 34433903
- Posaconazole treatment of refractory coccidioidomycosis in dogs. | Shubitz, LF., et al. 2021. J Vet Intern Med. 35: 2772-2777. PMID: 34658074
- Posaconazole inhibits multiple steps of the alphavirus replication cycle. | Varghese, FS., et al. 2022. Antiviral Res. 197: 105223. PMID: 34856248
- Chiral Nano-Liquid Chromatography and Dispersive Liquid-Liquid Microextraction Applied to the Analysis of Antifungal Drugs in Milk. | Dal Bosco, C., et al. 2021. Molecules. 26: PMID: 34885676
- Differential Growth Rates and In Vitro Drug Susceptibility to Currently Used Drugs for Multiple Isolates of Naegleria fowleri. | Russell, AC. and Kyle, DE. 2022. Microbiol Spectr. 10: e0189921. PMID: 35138140
- Formation and Characterisation of Posaconazole Hydrate Form. | Lykouras, M., et al. 2022. Pharmaceuticals (Basel). 16: PMID: 36678561
Inhibitor of:
Aspergillus, Candida albicans, CYP27B1, CYP27C1, CYP2J5, CYP46, CYP4A14, CYP4AA2, CYP4X1, CYP51A1, ERG25, Olfr955, and PXR.Activator of:
CYP51A1.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Posaconazole, 1 mg | sc-212571 | 1 mg | $353.00 |