Cyp3a16 Activators
Cyp3a16, a member of the cytochrome P450 family, plays a pivotal role in xenobiotic metabolism and steroid homeostasis within the liver. Predicted to enable demethylase activity, retinoic acid 4-hydroxylase activity, and steroid hydroxylase activity, this enzyme is actively involved in oxidative demethylation and steroid metabolic processes. Functioning primarily in the endoplasmic reticulum and membrane, Cyp3a16 contributes to the clearance and transformation of a wide range of exogenous compounds, ensuring the detoxification and elimination of various xenobiotics.
The general mechanisms underlying the activation of Cyp3a16 involve the interaction with specific signaling pathways and regulatory elements within hepatocytes. Several chemicals, acting as either direct or indirect activators, modulate the expression and activity of Cyp3a16. These activators engage with key receptors such as the pregnane X receptor (PXR), constitutive androstane receptor (CAR), and aryl hydrocarbon receptor (AhR), orchestrating a cascade of events that lead to enhanced enzymatic activities. For instance, ligands like rifampicin and omeprazole directly engage PXR, resulting in increased expression of Cyp3a16 and subsequent upregulation of its demethylase and steroid hydroxylase functions. Indirect activators, such as curcumin and licochalcone A, exert their influence through modulation of the nuclear factor erythroid 2-related factor 2 (Nrf2) pathway, indirectly impacting Cyp3a16 expression and activity. These intricate interactions emphasize the crucial role of Cyp3a16 in the hepatic detoxification machinery, ensuring the efficient metabolism of xenobiotics and maintenance of steroid homeostasis within the cellular milieu.
SEE ALSO...
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Rifampicin | 13292-46-1 | sc-200910 sc-200910A sc-200910B sc-200910C | 1 g 5 g 100 g 250 g | $95.00 $322.00 $663.00 $1438.00 | 6 | |
Rifampicin, a potent antibiotic, activates Cyp3a16 by inducing the pregnane X receptor (PXR) pathway. PXR activation leads to increased Cyp3a16 expression, enhancing its role in oxidative demethylation and steroid metabolism. The chemical influences hepatic cytochrome P450 enzymes, culminating in the upregulation of Cyp3a16 activity. | ||||||
Dexamethasone | 50-02-2 | sc-29059 sc-29059B sc-29059A | 100 mg 1 g 5 g | $76.00 $82.00 $367.00 | 36 | |
Dexamethasone, a glucocorticoid, indirectly activates Cyp3a16 through glucocorticoid receptor (GR) signaling. GR activation modulates the expression of Cyp3a16, promoting its involvement in oxidative demethylation and steroid metabolism. The chemical's influence on the endoplasmic reticulum and membrane localization of Cyp3a16 underscores its role in cellular processes related to drug metabolism and steroid homeostasis. | ||||||
Amodiaquine | 86-42-0 | sc-207282 | 10 mg | $342.00 | 1 | |
Amodiaquine, an antimalarial agent, acts as a direct activator of Cyp3a16 by interacting with the aryl hydrocarbon receptor (AhR). AhR activation leads to the upregulation of Cyp3a16, enhancing its demethylase and steroid hydroxylase activities. The chemical's impact on xenobiotic metabolism and drug detoxification underscores its role in the regulation of hepatic cytochrome P450 enzymes. | ||||||
Curcumin | 458-37-7 | sc-200509 sc-200509A sc-200509B sc-200509C sc-200509D sc-200509F sc-200509E | 1 g 5 g 25 g 100 g 250 g 1 kg 2.5 kg | $36.00 $68.00 $107.00 $214.00 $234.00 $862.00 $1968.00 | 47 | |
Curcumin, a natural polyphenol, indirectly activates Cyp3a16 by modulating the nuclear factor erythroid 2-related factor 2 (Nrf2) pathway. Nrf2 activation influences Cyp3a16 expression, contributing to its role in oxidative demethylation and steroid metabolism. The chemical's ability to impact cellular processes underscores its role in hepatic drug metabolism and xenobiotic detoxification. | ||||||
Omeprazole | 73590-58-6 | sc-202265 | 50 mg | $66.00 | 4 | |
Omeprazole, a proton pump inhibitor, serves as a direct activator of Cyp3a16 by engaging the pregnane X receptor (PXR) pathway. PXR activation leads to increased Cyp3a16 expression, enhancing its demethylase and steroid hydroxylase activities. The chemical's influence on hepatic cytochrome P450 enzymes underscores its role in oxidative demethylation and steroid metabolism. | ||||||
Efavirenz | 154598-52-4 | sc-207612 | 10 mg | $168.00 | 3 | |
Efavirenz, an antiretroviral drug, acts as a direct activator of Cyp3a16 by engaging the pregnane X receptor (PXR) pathway. PXR activation leads to increased Cyp3a16 expression, enhancing its demethylase and steroid hydroxylase activities. The chemical's influence on hepatic cytochrome P450 enzymes underscores its role in oxidative demethylation and steroid metabolism. | ||||||
Baicalein | 491-67-8 | sc-200494 sc-200494A sc-200494B sc-200494C | 10 mg 100 mg 500 mg 1 g | $31.00 $41.00 $159.00 $286.00 | 12 | |
Baicalein, a natural flavonoid, indirectly activates Cyp3a16 through modulation of the nuclear factor erythroid 2-related factor 2 (Nrf2) pathway. Nrf2 activation influences Cyp3a16 expression, contributing to its role in oxidative demethylation and steroid metabolism. The chemical's impact on cellular processes underscores its role in hepatic drug metabolism and xenobiotic detoxification. | ||||||
Resveratrol | 501-36-0 | sc-200808 sc-200808A sc-200808B | 100 mg 500 mg 5 g | $60.00 $185.00 $365.00 | 64 | |
Resveratrol, a natural polyphenol, indirectly activates Cyp3a16 through modulation of the nuclear factor erythroid 2-related factor 2 (Nrf2) pathway. Nrf2 activation influences Cyp3a16 expression, contributing to its role in oxidative demethylation and steroid metabolism. The chemical's impact on cellular processes underscores its role in hepatic drug metabolism and xenobiotic detoxification. | ||||||