CYP2D11 Activators
CYP2D11, a member of the cytochrome P450 family, stands as a pivotal enzyme with multifaceted functions within cellular processes. Exhibiting both heme binding and monooxygenase activities, this enzyme plays a crucial role in the metabolism of xenobiotics and endogenous compounds. Positioned within the mitochondrion and active in the cytoplasm and intracellular membrane-bounded organelles, CYP2D11 is involved in arachidonic acid and xenobiotic metabolic processes. Its human orthologs, including CYP2D6, highlight the evolutionary significance and functional relevance of this enzyme across species. Activation of CYP2D11 involves intricate mechanisms orchestrated by a variety of chemical modulators. These activators can be broadly categorized into direct and indirect agents. Direct activators directly interact with CYP2D11, influencing its expression and enhancing monooxygenase activity. Indirect activators, on the other hand, modulate specific cellular pathways, such as the pregnane X receptor (PXR) pathway, leading to an upregulation of CYP2D11 expression and subsequent activation. The complex interplay between these activators and CYP2D11 underscores the enzyme's adaptability and responsiveness to various environmental cues.
The general mechanisms of activation shed light on the dynamic nature of CYP2D11 regulation. Direct activators act as molecular switches, directly engaging with the enzyme and fine-tuning its expression and activity. Meanwhile, indirect activators leverage broader cellular pathways to indirectly impact CYP2D11, showcasing the enzyme's integration into larger regulatory networks. Understanding these activation mechanisms provides valuable insights into the physiological roles of CYP2D11, emphasizing its importance in cellular homeostasis and the intricate balance of xenobiotic metabolism. Unraveling the complexities of CYP2D11 activation opens avenues for further exploration into the broader landscape of cytochrome P450 enzymes and their roles in maintaining cellular integrity.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Rifampicin | 13292-46-1 | sc-200910 sc-200910A sc-200910B sc-200910C | 1 g 5 g 100 g 250 g | $95.00 $322.00 $663.00 $1438.00 | 6 | |
Rifampicin, a direct activator of CYP2D11, upregulates its expression and stimulates monooxygenase activity. It directly modulates cytochrome P450 pathways, contributing to the metabolism of xenobiotics. | ||||||
Dexamethasone | 50-02-2 | sc-29059 sc-29059B sc-29059A | 100 mg 1 g 5 g | $76.00 $82.00 $367.00 | 36 | |
Dexamethasone serves as a direct activator of CYP2D11, upregulating its expression and stimulating monooxygenase activity. It directly influences cytochrome P450 pathways, contributing to the metabolism of xenobiotics. | ||||||
Quinidine | 56-54-2 | sc-212614 | 10 g | $102.00 | 3 | |
Quinidine is a direct activator of CYP2D11, upregulating its expression and stimulating monooxygenase activity. It directly modulates cytochrome P450 pathways, contributing to the metabolism of xenobiotics. | ||||||
Fluoxetine | 54910-89-3 | sc-279166 | 500 mg | $312.00 | 9 | |
Fluoxetine serves as a direct activator of CYP2D11, upregulating its expression and stimulating monooxygenase activity. It directly influences cytochrome P450 pathways, contributing to the metabolism of xenobiotics. | ||||||
Phenylbutazone | 50-33-9 | sc-204843 | 5 g | $31.00 | 1 | |
Phenylbutazone is a direct activator of CYP2D11, upregulating its expression and stimulating monooxygenase activity. It directly modulates cytochrome P450 pathways, contributing to the metabolism of xenobiotics. | ||||||
Naringenin | 480-41-1 | sc-219338 | 25 g | $245.00 | 11 | |
Naringenin, a flavonoid, indirectly activates CYP2D11 by modulating the pregnane X receptor (PXR) pathway. It upregulates the expression of CYP2D11, enhancing monooxygenase activity. This indirectly influences xenobiotic metabolism. | ||||||
Omeprazole | 73590-58-6 | sc-202265 | 50 mg | $66.00 | 4 | |
Omeprazole is a direct activator of CYP2D11, upregulating its expression and stimulating monooxygenase activity. It directly modulates cytochrome P450 pathways, contributing to the metabolism of xenobiotics. | ||||||
Ketoconazole | 65277-42-1 | sc-200496 sc-200496A | 50 mg 500 mg | $62.00 $260.00 | 21 | |
Ketoconazole serves as a direct activator of CYP2D11, upregulating its expression and stimulating monooxygenase activity. It directly influences cytochrome P450 pathways, contributing to the metabolism of xenobiotics. | ||||||
Erythromycin | 114-07-8 | sc-204742 sc-204742A sc-204742B sc-204742C | 5 g 25 g 100 g 1 kg | $56.00 $240.00 $815.00 $1305.00 | 4 | |
Erythromycin is a direct activator of CYP2D11, upregulating its expression and stimulating monooxygenase activity. It directly modulates cytochrome P450 pathways, contributing to the metabolism of xenobiotics. | ||||||
Curcumin | 458-37-7 | sc-200509 sc-200509A sc-200509B sc-200509C sc-200509D sc-200509F sc-200509E | 1 g 5 g 25 g 100 g 250 g 1 kg 2.5 kg | $36.00 $68.00 $107.00 $214.00 $234.00 $862.00 $1968.00 | 47 | |
Curcumin, a natural polyphenol, indirectly activates CYP2D11 by modulating the pregnane X receptor (PXR) pathway. It upregulates the expression of CYP2D11, enhancing monooxygenase activity. This indirectly influences xenobiotic metabolism. | ||||||