Cyp2c66 Activators
Cyp2c66, a cytochrome P450 enzyme, exhibits diverse functions, including caffeine oxidase, heme binding, and monooxygenase activities. Acting upstream of hematopoietic progenitor cell differentiation, Cyp2c66 plays a crucial role in cellular processes. Located in the cytoplasm and intracellular membrane-bounded organelles, Cyp2c66 has been implicated in diseases such as Plasmodium falciparum malaria, end-stage renal disease, eosinophilic esophagitis, invasive aspergillosis, and multiple chemical sensitivity. As an ortholog of CYP2C19, Cyp2c66 is part of the cytochrome P450 family.
Activation of Cyp2c66 involves both direct and indirect mechanisms mediated by various chemicals. Direct activators, such as Rifampicin, Indomethacin, and Troleandomycin, upregulate Cyp2c66 expression, stimulating caffeine oxidase and monooxygenase activities. Indirect activators, like Auranofin, Quercetin, and Sulforaphane, modulate Nrf2 pathway, enhancing Cyp2c66 expression and activity. The general mechanisms of activation revolve around the modulation of Cyp2c66 expression and function through cytochrome P450 and Nrf2 pathways, contributing to its crucial role in xenobiotic metabolism and cellular processes. Understanding these activators provides insights into potential strategies for manipulating Cyp2c66 activity in various physiological contexts.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Rifampicin | 13292-46-1 | sc-200910 sc-200910A sc-200910B sc-200910C | 1 g 5 g 100 g 250 g | $95.00 $322.00 $663.00 $1438.00 | 6 | |
Rifampicin is a direct activator of Cyp2c66, upregulating its expression and stimulating caffeine oxidase and monooxygenase activities. It directly influences cytochrome P450 pathways, contributing to the metabolism of xenobiotics and caffeine. | ||||||
Indomethacin | 53-86-1 | sc-200503 sc-200503A | 1 g 5 g | $28.00 $37.00 | 18 | |
Indomethacin serves as a direct activator of Cyp2c66, upregulating its expression and stimulating caffeine oxidase and monooxygenase activities. It directly modulates cytochrome P450 pathways, contributing to the metabolism of xenobiotics and caffeine. | ||||||
Auranofin | 34031-32-8 | sc-202476 sc-202476A sc-202476B | 25 mg 100 mg 2 g | $150.00 $210.00 $1899.00 | 39 | |
Auranofin, a gold-containing compound, indirectly activates Cyp2c66 by modulating the Nrf2 pathway. It upregulates the expression of Cyp2c66, enhancing caffeine oxidase and monooxygenase activities. This indirectly influences xenobiotic metabolism and caffeine degradation. | ||||||
Quercetin | 117-39-5 | sc-206089 sc-206089A sc-206089E sc-206089C sc-206089D sc-206089B | 100 mg 500 mg 100 g 250 g 1 kg 25 g | $11.00 $17.00 $108.00 $245.00 $918.00 $49.00 | 33 | |
Quercetin, a flavonoid, indirectly activates Cyp2c66 by modulating the Nrf2 pathway. It upregulates the expression of Cyp2c66, enhancing caffeine oxidase and monooxygenase activities. This indirectly influences xenobiotic metabolism and caffeine degradation. | ||||||
Nelfinavir | 159989-64-7 | sc-507314 | 10 mg | $168.00 | ||
Nelfinavir serves as a direct activator of Cyp2c66, upregulating its expression and stimulating caffeine oxidase and monooxygenase activities. It directly modulates cytochrome P450 pathways, contributing to the metabolism of xenobiotics and caffeine. | ||||||
D,L-Sulforaphane | 4478-93-7 | sc-207495A sc-207495B sc-207495C sc-207495 sc-207495E sc-207495D | 5 mg 10 mg 25 mg 1 g 10 g 250 mg | $150.00 $286.00 $479.00 $1299.00 $8299.00 $915.00 | 22 | |
Sulforaphane, a natural compound, indirectly activates Cyp2c66 by modulating the Nrf2 pathway. It upregulates the expression of Cyp2c66, enhancing caffeine oxidase and monooxygenase activities. This indirectly influences xenobiotic metabolism and caffeine degradation. | ||||||
Diclofenac Sodium | 15307-79-6 | sc-202136 sc-202136A | 5 g 25 g | $40.00 $125.00 | 4 | |
Diclofenac is a direct activator of Cyp2c66, upregulating its expression and stimulating caffeine oxidase and monooxygenase activities. It directly influences cytochrome P450 pathways, contributing to the metabolism of xenobiotics and caffeine. | ||||||
Chrysin | 480-40-0 | sc-204686 | 1 g | $37.00 | 13 | |
Chrysin, a natural flavonoid, indirectly activates Cyp2c66 by modulating the Nrf2 pathway. It upregulates the expression of Cyp2c66, enhancing caffeine oxidase and monooxygenase activities. This indirectly influences xenobiotic metabolism and caffeine degradation. | ||||||
Nifedipine | 21829-25-4 | sc-3589 sc-3589A | 1 g 5 g | $58.00 $170.00 | 15 | |
Nifedipine serves as a direct activator of Cyp2c66, upregulating its expression and stimulating caffeine oxidase and monooxygenase activities. It directly modulates cytochrome P450 pathways, contributing to the metabolism of xenobiotics and caffeine. | ||||||
Oltipraz | 64224-21-1 | sc-205777 sc-205777A | 500 mg 1 g | $286.00 $622.00 | ||
Oltipraz, a synthetic compound, indirectly activates Cyp2c66 by modulating the Nrf2 pathway. It upregulates the expression of Cyp2c66, enhancing caffeine oxidase and monooxygenase activities. This indirectly influences xenobiotic metabolism and caffeine degradation. | ||||||