Cyp2c55 Inhibitors
Chemical inhibitors of Cyp2c55 utilize various mechanisms to impede the function of the enzyme. Miconazole, ketoconazole, clotrimazole, and fluconazole are antifungal azoles that inhibit the enzyme by binding to the heme iron within its active site. This key interaction hinders the enzyme's capacity to metabolize its substrates, effectively interrupting its normal biological functions. Similarly, sulfaphenazole acts as a selective competitive inhibitor, occupying the active site and thus blocking the access of substrates. This competitive binding directly prevents the enzyme from processing other molecules it would typically metabolize.
Ticlopidine metabolizes into intermediates that covalently bind to Cyp2c55, leading to irreversible inhibition and a lasting reduction in enzyme activity. Phenylbutazone follows a competitive route of inhibition, taking up space within the catalytic site and precluding the metabolism of other substrates. Alternatively, methoxsalen operates as a mechanism-based inhibitor, forming a covalent bond with the enzyme's active site, which results in permanent inhibition. Omeprazole also achieves irreversible binding but through a different intermediate, sulphenamide, which interacts with the enzyme's heme group. Chloramphenicol and isoniazid inhibit Cyp2c55 by binding to the enzyme's active site, obstructing its normal interactions with substrates. Lastly, 1-aminobenzotriazole serves as a nonspecific inhibitor, covalently attaching to the heme iron of Cyp2c55, leading to an irreversible cessation of its enzymatic activity. Each chemical's interaction with Cyp2c55 ultimately disrupts the enzyme's metabolic role within the biological system.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Miconazole | 22916-47-8 | sc-204806 sc-204806A | 1 g 5 g | $65.00 $157.00 | 2 | |
Miconazole, an antifungal azole, can inhibit Cyp2c55 by binding to the heme iron within the enzyme's active site, a feature common to cytochrome P450 enzymes, thereby blocking the enzyme's ability to metabolize its substrates. | ||||||
Ketoconazole | 65277-42-1 | sc-200496 sc-200496A | 50 mg 500 mg | $62.00 $260.00 | 21 | |
Ketoconazole is another azole antifungal that inhibits Cyp2c55 by interfering with the heme group of the protein, which is essential for the enzymatic activity. This binding prevents the cytochrome P450 enzyme from carrying out its normal metabolic functions. | ||||||
Clotrimazole | 23593-75-1 | sc-3583 sc-3583A | 100 mg 1 g | $41.00 $56.00 | 6 | |
Clotrimazole, a synthetic antifungal drug, can inhibit Cyp2c55 by binding to the enzyme's active site, which contains the heme iron crucial for its enzymatic activity. This interaction inhibits the enzyme's function by preventing the metabolism of its natural substrates. | ||||||
Fluconazole | 86386-73-4 | sc-205698 sc-205698A | 500 mg 1 g | $53.00 $84.00 | 14 | |
Fluconazole, a triazole antifungal, inhibits Cyp2c55 by binding to the heme group within the enzyme. This action disrupts the normal metabolic activity of the enzyme by blocking the access of substrates to the catalytic site. | ||||||
Ticlopidine Hydrochloride | 53885-35-1 | sc-205861 sc-205861A | 1 g 5 g | $31.00 $97.00 | 2 | |
Ticlopidine can metabolize into reactive intermediates that can irreversibly bind to Cyp2c55, thus inhibiting its activity. This covalent binding leads to a sustained decrease in enzyme activity. | ||||||
Phenylbutazone | 50-33-9 | sc-204843 | 5 g | $31.00 | 1 | |
Phenylbutazone, a nonsteroidal anti-inflammatory drug, can inhibit Cyp2c55 through competitive inhibition by occupying the catalytic site of the enzyme, thus preventing the metabolism of other substrates by the enzyme. | ||||||
Methoxsalen (8-Methoxypsoralen) | 298-81-7 | sc-200505 | 1 g | $27.00 | 1 | |
Methoxsalen is a furanocoumarin that can act as a mechanism-based inhibitor of Cyp2c55, forming a covalent bond with the active site of the enzyme and leading to irreversible inhibition. | ||||||
Omeprazole | 73590-58-6 | sc-202265 | 50 mg | $66.00 | 4 | |
Omeprazole, a proton pump inhibitor, can inhibit Cyp2c55 by metabolizing to sulphenamide in the acidic environment of the stomach, which can then irreversibly bind to the heme group of the enzyme. | ||||||
Chloramphenicol | 56-75-7 | sc-3594 | 25 g | $53.00 | 10 | |
Chloramphenicol is an antibiotic that can inhibit Cyp2c55 by binding to the enzyme's active site, thus preventing its interaction with endogenous substrates necessary for its metabolic function. | ||||||
Isoniazid | 54-85-3 | sc-205722 sc-205722A sc-205722B | 5 g 50 g 100 g | $25.00 $99.00 $143.00 | ||
Isoniazid, an antibacterial agent used primarily for tuberculosis, can form a hydrazine metabolite that can non-selectively inhibit Cyp2c55 by binding to the enzyme's active site, thus inhibiting its metabolic capacity. | ||||||