CYP2AB1 Activators
CYP2AB1, a cytochrome P450 enzyme, is predicted to possess heme binding activity, oxidoreductase activity, acting on paired donors with incorporation or reduction of molecular oxygen, and steroid hydroxylase activity. It is involved in organic acid metabolic processes and xenobiotic metabolic processes, active in the cytoplasm and intracellular membrane-bounded organelle, and is orthologous to the pseudogene CYP2AB1P in humans.
Activation of CYP2AB1 involves a multifaceted interplay of direct and indirect mechanisms influenced by various chemicals. For example, the antimalarial Amodiaquine and the glucocorticoid Dexamethasone may directly induce CYP2AB1 by modulating cytochrome P450 enzymes or activating nuclear receptors, respectively. Additionally, compounds like the thiazolidinedione Troglitazone and the protease inhibitor Nelfinavir may indirectly upregulate CYP2AB1 by influencing PPAR signaling or modulating cytochrome P450 enzymes. The activation of CYP2AB1 is intricately linked to its role in xenobiotic metabolism and steroid hydroxylation, providing insights into potential interactions with drugs and foreign compounds. Understanding these activation mechanisms contributes to the broader understanding of CYP2AB1 function and its impact on drug metabolism.
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Items 1 to 10 of 11 total
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Amodiaquine | 86-42-0 | sc-207282 | 10 mg | $342.00 | 1 | |
Antimalarial impacting CYP2AB1. Modulates cytochrome P450 enzymes, potentially influencing xenobiotic metabolism and steroid hydroxylase activity related to CYP2AB1. | ||||||
Dexamethasone | 50-02-2 | sc-29059 sc-29059B sc-29059A | 100 mg 1 g 5 g | $91.00 $139.00 $374.00 | 36 | |
Glucocorticoid potentially inducing CYP2AB1. Activates nuclear receptors, potentially upregulating CYP2AB1 expression and enhancing steroid hydroxylase activity involved in organic acid metabolism. | ||||||
Troglitazone | 97322-87-7 | sc-200904 sc-200904B sc-200904A | 5 mg 10 mg 25 mg | $110.00 $204.00 $435.00 | 9 | |
Thiazolidinedione potentially influencing CYP2AB1. Modulates cytochrome P450 enzymes, potentially impacting xenobiotic metabolism and steroid hydroxylase activity related to CYP2AB1. | ||||||
Nelfinavir | 159989-64-7 | sc-507314 | 10 mg | $168.00 | ||
Protease inhibitor potentially influencing CYP2AB1. Modulates cytochrome P450 enzymes, potentially impacting xenobiotic metabolism and steroid hydroxylase activity related to CYP2AB1. | ||||||
Clofibrate | 637-07-0 | sc-200721 | 1 g | $33.00 | ||
Peroxisome proliferator-activated receptor agonist impacting CYP2AB1. Modulates PPAR signaling, potentially upregulating CYP2AB1 expression and enhancing steroid hydroxylase activity involved in organic acid metabolism. | ||||||
Resveratrol | 501-36-0 | sc-200808 sc-200808A sc-200808B | 100 mg 500 mg 5 g | $80.00 $220.00 $460.00 | 64 | |
Polyphenol potentially influencing CYP2AB1. Modulates cytochrome P450 enzymes, potentially impacting xenobiotic metabolism and steroid hydroxylase activity related to CYP2AB1. | ||||||
Clotrimazole | 23593-75-1 | sc-3583 sc-3583A | 100 mg 1 g | $42.00 $57.00 | 6 | |
Antifungal potentially influencing CYP2AB1. Modulates cytochrome P450 enzymes, potentially impacting xenobiotic metabolism and steroid hydroxylase activity related to CYP2AB1. | ||||||
Pioglitazone | 111025-46-8 | sc-202289 sc-202289A | 1 mg 5 mg | $55.00 $125.00 | 13 | |
Thiazolidinedione potentially influencing CYP2AB1. Modulates cytochrome P450 enzymes, potentially impacting xenobiotic metabolism and steroid hydroxylase activity related to CYP2AB1. | ||||||
Diclofenac Sodium | 15307-79-6 | sc-202136 sc-202136A | 5 g 25 g | $41.00 $128.00 | 4 | |
Nonsteroidal anti-inflammatory drug potentially influencing CYP2AB1. Modulates cytochrome P450 enzymes, potentially impacting xenobiotic metabolism and steroid hydroxylase activity related to CYP2AB1. | ||||||
3′-Azido-3′-deoxythymidine | 30516-87-1 | sc-203319 | 10 mg | $61.00 | 2 | |
Antiretroviral potentially influencing CYP2AB1. Modulates cytochrome P450 enzymes, potentially impacting xenobiotic metabolism and steroid hydroxylase activity related to CYP2AB1. | ||||||