CYP2A22 Activators
CYP2A22, a cytochrome P450 enzyme, is predicted to possess enzyme binding, heme binding, and monooxygenase activities, and is involved in coumarin metabolic processes, epoxygenase P450 pathway, and xenobiotic metabolic processes. It is predicted to be located in the cytoplasmic microtubule, active in the cytoplasm and intracellular membrane-bounded organelle, and is orthologous to human genes associated with nicotine dependence and warfarin resistance.
Activation of CYP2A22 involves a complex interplay of direct and indirect mechanisms influenced by various chemicals. For instance, the proton pump inhibitor Omeprazole and the barbiturate Phenobarbital may directly induce CYP2A22 by modulating cytochrome P450 enzymes or activating nuclear receptors, respectively. Additionally, compounds like the aryl hydrocarbon receptor agonist Alpha-Naphthoflavone and the antibiotic Rifampicin may indirectly upregulate CYP2A22 by influencing AhR signaling or activating nuclear receptors. The activation of CYP2A22 is intricately linked to its role in xenobiotic metabolism and coumarin-related processes. Understanding these activation mechanisms provides insights into the regulation of CYP2A22 and its potential impact on drug metabolism and susceptibility to xenobiotics.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Omeprazole | 73590-58-6 | sc-202265 | 50 mg | $67.00 | 4 | |
Proton pump inhibitor influencing CYP2A22. Modulates cytochrome P450 enzymes, potentially impacting coumarin metabolic processes and xenobiotic metabolism related to CYP2A22. | ||||||
α-Naphthoflavone | 604-59-1 | sc-257037 sc-257037A sc-257037B sc-257037C | 1 g 5 g 25 g 100 g | $34.00 $46.00 $156.00 $500.00 | 3 | |
Aryl hydrocarbon receptor agonist impacting CYP2A22. Modulates AhR signaling, potentially upregulating CYP2A22 expression and influencing xenobiotic metabolism and coumarin metabolic processes. | ||||||
Dicoumarol | 66-76-2 | sc-205647 sc-205647A | 500 mg 5 g | $20.00 $40.00 | 8 | |
Vitamin K antagonist influencing CYP2A22. Alters the metabolism of coumarin-related compounds, potentially affecting CYP2A22 activity involved in coumarin metabolic processes. | ||||||
Methoxsalen (8-Methoxypsoralen) | 298-81-7 | sc-200505 | 1 g | $28.00 | 1 | |
Psoralen influencing CYP2A22. Modulates cytochrome P450 enzymes, potentially impacting xenobiotic metabolism and coumarin metabolic processes related to CYP2A22. | ||||||
3-Methylcholanthrene | 56-49-5 | sc-252030 sc-252030A | 100 mg 250 mg | $388.00 $831.00 | 2 | |
Polycyclic aromatic hydrocarbon inducing CYP2A22. Activates AhR, potentially upregulating CYP2A22 expression and influencing xenobiotic metabolism and coumarin metabolic processes. | ||||||
Quercetin | 117-39-5 | sc-206089 sc-206089A sc-206089E sc-206089C sc-206089D sc-206089B | 100 mg 500 mg 100 g 250 g 1 kg 25 g | $11.00 $17.00 $110.00 $250.00 $936.00 $50.00 | 33 | |
Flavonoid influencing CYP2A22. Modulates cytochrome P450 enzymes, potentially impacting xenobiotic metabolism and coumarin metabolic processes related to CYP2A22. | ||||||
Rifampicin | 13292-46-1 | sc-200910 sc-200910A sc-200910B sc-200910C | 1 g 5 g 100 g 250 g | $97.00 $328.00 $676.00 $1467.00 | 6 | |
Antibiotic inducing CYP2A22. Activates nuclear receptors, potentially upregulating CYP2A22 expression and enhancing monooxygenase activity involved in xenobiotic metabolism and coumarin metabolic processes. | ||||||
Curcumin | 458-37-7 | sc-200509 sc-200509A sc-200509B sc-200509C sc-200509D sc-200509F sc-200509E | 1 g 5 g 25 g 100 g 250 g 1 kg 2.5 kg | $37.00 $69.00 $109.00 $218.00 $239.00 $879.00 $1968.00 | 47 | |
Polyphenol impacting CYP2A22. Modulates cytochrome P450 enzymes, potentially influencing xenobiotic metabolism and coumarin metabolic processes related to CYP2A22. | ||||||
Ethoxyquin | 91-53-2 | sc-205686 sc-205686A | 100 g 250 g | $62.00 $124.00 | ||
Antioxidant influencing CYP2A22. Modulates cytochrome P450 enzymes, potentially impacting xenobiotic metabolism and coumarin metabolic processes related to CYP2A22. | ||||||